Journal of Applied Physiology Track the topics, authors and articles important to you
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 77: 1206-1216, 1994;
8750-7587/94 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lambert, R. K.
Right arrow Articles by Pack, R. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lambert, R. K.
Right arrow Articles by Pack, R. J.

Journal of Applied Physiology, Vol 77, Issue 3 1206-1216, Copyright © 1994 by American Physiological Society

ARTICLES

Physical determinants of bronchial mucosal folding

R. K. Lambert, S. L. Codd, M. R. Alley and R. J. Pack
Department of Physics, Massey University, Palmerston North, New Zealand.

It has recently been proposed, on the basis of a theoretical analysis, that the folding of the mucosa provides a significant component of airway stiffness. The model predicted that the stiffness of an airway was directly related to the number of epithelial folds that developed. In this study we examine the possibility that the folding pattern is determined by the physical requirements that the folding membrane must stay within the boundary of the smooth muscle wall, that the submucosal mass is constant, and that the strain energy of the folding membrane is the minimum possible within the geometric constraints. Model predictions are compared with morphometric data from the noncartilaginous airways of 17 sheep lungs. The data are in agreement with our predictions, which are based on the assumption that the folding membrane thickness is proportional to the submucosal thickness (in a fully dilated airway). The outcome of this analysis is that the increase in intrinsic stiffness of the folding membrane resulting from the increased thickness outweighs the decrease in stiffness conferred by the fewer folds required by the thicker submucosa. It is suggested that the increase in folding membrane thickness observed in asthma could be viewed as a protective mechanism that tends to reduce hyperresponsiveness.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
A. A. Tomei, M. M. Choe, and M. A. Swartz
Effects of dynamic compression on lentiviral transduction in an in vitro airway wall model
Am J Physiol Lung Cell Mol Physiol, January 1, 2008; 294(1): L79 - L86.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
C. Y. Seow
Videomicrometry of lung slices: a glimpse of the dynamic airway parenchyma interaction in emphysematous lungs
Eur. Respir. J., October 1, 2007; 30(4): 611 - 612.
[Full Text] [PDF]

Home page
 Eur Respir JHome page
A. L. James and S. Wenzel
Clinical relevance of airway remodelling in airway diseases
Eur. Respir. J., July 1, 2007; 30(1): 134 - 155.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
S. S. An, T. R. Bai, J. H. T. Bates, J. L. Black, R. H. Brown, V. Brusasco, P. Chitano, L. Deng, M. Dowell, D. H. Eidelman, et al.
Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma
Eur. Respir. J., May 1, 2007; 29(5): 834 - 860.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
E. D. Fixman, A. Stewart, and J. G. Martin
Basic mechanisms of development of airway structural changes in asthma
Eur. Respir. J., February 1, 2007; 29(2): 379 - 389.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
C. Bergeron and L.-P. Boulet
Structural changes in airway diseases: characteristics, mechanisms, consequences, and pharmacologic modulation.
Chest, April 1, 2006; 129(4): 1068 - 1087.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. Naire and O. E. Jensen
Epithelial cell deformation during surfactant-mediated airway reopening: a theoretical model
J Appl Physiol, August 1, 2005; 99(2): 458 - 471.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
V. Brusasco and R. Pellegrino
Invited Review: Complexity of factors modulating airway narrowing in vivo: relevance to assessment of airway hyperresponsiveness
J Appl Physiol, September 1, 2003; 95(3): 1305 - 1313.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. C. Anafi, K. C. Beck, and T. A. Wilson
Impedance, gas mixing, and bimodal ventilation in constricted lungs
J Appl Physiol, March 1, 2003; 94(3): 1003 - 1011.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
L. Wang, B. E. McParland, and P. D. Pare
The Functional Consequences of Structural Changes in the Airways: Implications for Airway Hyperresponsiveness in Asthma
Chest, March 1, 2003; 123(2007): 356S - 362S.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
N. J. Vanacker, E. Palmans, R. A. Pauwels, and J. C. Kips
Effect of Combining Salmeterol and Fluticasone on the Progression of Airway Remodeling
Am. J. Respir. Crit. Care Med., October 15, 2002; 166(8): 1128 - 1134.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
E. Palmans, R.A. Pauwels, and J.C. Kips
Repeated allergen exposure changes collagen composition in airways of sensitised Brown Norway rats
Eur. Respir. J., August 1, 2002; 20(2): 280 - 285.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
D. J. TSCHUMPERLIN and J. M. DRAZEN
Mechanical Stimuli to Airway Remodeling
Am. J. Respir. Crit. Care Med., November 15, 2001; 164(10): S90 - 94.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. C. Anafi and T. A. Wilson
Airway stability and heterogeneity in the constricted lung
J Appl Physiol, September 1, 2001; 91(3): 1185 - 1192.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
U. Holzhauser and R. K. Lambert
Analysis of tracheal mechanics and applications
J Appl Physiol, July 1, 2001; 91(1): 290 - 297.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. K. Lambert, P. D. Pare, and M. Okazawa
Stiffness of peripheral airway folding membrane in rabbits
J Appl Physiol, June 1, 2001; 90(6): 2041 - 2047.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. Okazawa, P. D. Pare, and R. K. Lambert
Compliance of peripheral airways deduced from morphometry
J Appl Physiol, December 1, 2000; 89(6): 2373 - 2381.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. Uhlig, A. Wohlsen, F. Brasch, C. Y. Seow, and P. D. Pare
Can airways close completely?
J Appl Physiol, December 1, 2000; 89(6): 2521 - 2522.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
H. J. L. BRACKEL, O. F. PEDERSEN, P. G. H. MULDER, S. E. OVERBEEK, K. F. KERREBIJN, and J. M. BOGAARD
Central Airways Behave More Stiffly during Forced Expiration in Patients with Asthma
Am. J. Respir. Crit. Care Med., September 1, 2000; 162(3): 896 - 904.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
T. R. BAI, J. COOPER, T. KOELMEYER, P. D. PARE, and T. D. WEIR
The Effect of Age and Duration of Disease on Airway Structure in Fatal Asthma
Am. J. Respir. Crit. Care Med., August 1, 2000; 162(2): 663 - 669.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
H. TIDDENS, M. SILVERMAN, and A. BUSH
The Role of Inflammation in Airway Disease . Remodeling
Am. J. Respir. Crit. Care Med., August 1, 2000; 162(2): S7 - 10.
[Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. Y. Seow, L. Wang, and P. D. Pare
Airway narrowing and internal structural constraints
J Appl Physiol, February 1, 2000; 88(2): 527 - 533.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
E. PALMANS, J. C. KIPS, and R. A. PAUWELS
Prolonged Allergen Exposure Induces Structural Airway Changes in Sensitized Rats
Am. J. Respir. Crit. Care Med., February 1, 2000; 161(2): 627 - 635.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
N. G. CARROLL, S. PERRY, A. KARKHANIS, S. HARJI, J. BUTT, A. L. JAMES, and F. H. Y. GREEN
The Airway Longitudinal Elastic Fiber Network and Mucosal Folding in Patients with Asthma
Am. J. Respir. Crit. Care Med., January 1, 2000; 161(1): 244 - 248.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
C. Y. SEOW, R. R. SCHELLENBERG, and P. D. PARE
Structural and Functional Changes in the Airway Smooth Muscle of Asthmatic Subjects
Am. J. Respir. Crit. Care Med., November 1, 1998; 158(2007): S179 - S186.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
B. R. Wiggs, C. A. Hrousis, J. M. Drazen, and R. D. Kamm
On the mechanism of mucosal folding in normal and asthmatic airways
J Appl Physiol, December 1, 1997; 83(6): 1814 - 1821.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. K. Lambert and P. D. Pare
Lung parenchymal shear modulus, airway wall remodeling, and bronchial hyperresponsiveness
J Appl Physiol, July 1, 1997; 83(1): 140 - 147.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. J. Hill, T. A. Wilson, and R. K. Lambert
Effects of surface tension and intraluminal fluid on mechanics of small airways
J Appl Physiol, January 1, 1997; 82(1): 233 - 239.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online