Journal of Applied Physiology http://www.adinstruments.com/labchart/faseb
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 77: 834-839, 1994;
8750-7587/94 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Schreiber, M. D.
Right arrow Articles by Torgerson, L. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Schreiber, M. D.
Right arrow Articles by Torgerson, L. J.

Journal of Applied Physiology, Vol 77, Issue 2 834-839, Copyright © 1994 by American Physiological Society

ARTICLES

Effects of cocaine, benzoylecgonine, and cocaine metabolites in cannulated pressurized fetal sheep cerebral arteries

M. D. Schreiber, J. A. Madden, R. F. Covert and L. J. Torgerson
Department of Pediatrics, Pritzker School of Medicine, University of Chicago, Illinois 60637.

Prenatal cocaine exposure has been reported to cause neurovascular complications in the developing fetus. To determine the effect of cocaine on the fetal neurovasculature, we studied the in vitro response of fetal sheep cerebral arteries to cocaine and cocaine metabolites. The change in diameter of cannulated pressurized cerebral artery segments from fetal sheep was measured using a video microscaler system. Cumulative dose-response curves (10(-12)-10(-4) M) were generated for cocaine and the major cocaine metabolites in fetal sheep cerebral artery segments. Benzoylecgonine (> 10(-10) M) also caused concentration-dependent constriction, and cerebral artery segments were significantly more sensitive to benzoylecgonine than to cocaine and the other cocaine metabolites. Benzoylecgonine-induced vasoconstriction appeared to be mediated through alpha-adrenergic stimulation, predominantly through stimulation of alpha 1-adrenergic receptor subtypes. We conclude that cocaine and benzoylecgonine cause significant fetal cerebral artery vasoconstriction in vitro. Cocaine and benzoylecgonine-induced cerebral vasoconstriction may contribute to the perinatal neurovascular complications associated with prenatal cocaine exposure.


This article has been cited by other articles:


Home page
 J. Pharmacol. Exp. Ther.Home page
S. Ferreira, W. J. Crumb Jr., C. G. Carlton, and C. W. Clarkson
Effects of Cocaine and Its Major Metabolites on the HERG-Encoded Potassium Channel
J. Pharmacol. Exp. Ther., October 1, 2001; 299(1): 220 - 226.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
R. Robinson, H. Iida, T. P. O'Brien, M. A. Pane, R. J. Traystman, and C. A. Gleason
Comparison of cerebrovascular effects of intravenous cocaine injection in fetal, newborn, and adult sheep
Am J Physiol Heart Circ Physiol, July 1, 2000; 279(1): H1 - H6.
[Abstract] [Full Text] [PDF]

Home page
 Journal of Pharmacy PracticeHome page
J. W. Lipton, K. P. Mangan, and J. M. Silvestri
Acute Cocaine Toxicity: Pharmacology and Clinical Presentations in Adult and Pediatric Populations
Journal of Pharmacy Practice, April 1, 2000; 13(2): 159 - 169.
[Abstract] [PDF]

Home page
 Drug Metab. Dispos.Home page
L. M. Iwamoto, C. M. Moore, N. Fujiwara, M. J. Christ, D. M. Gries, and K. T. Nakamura
m-Hydroxy Benzoylecgonine Recovery in Fetal Guinea Pigs
Drug Metab. Dispos., March 1, 2000; 28(3): 335 - 338.
[Abstract] [Full Text] [PDF]

Home page
 Reproductive SciencesHome page
T. Downs, J. Padbury, L. Blount, K. Kashiwai, and K. Chan
Ovine Fetal-Placental Cocaine Pharmacokinetics During Continuous Cocaine Infusion
Reproductive Sciences, July 1, 1996; 3(4): 185 - 190.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online