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J Appl Physiol 77: 751-756, 1994;
8750-7587/94 $5.00
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Journal of Applied Physiology, Vol 77, Issue 2 751-756, Copyright © 1994 by American Physiological Society

ARTICLES

Magnesium attenuates pulmonary hypertension due to hypoxia and group B streptococci

M. E. Anderson, T. M. Burnette, D. R. Geiser and W. Janjindamai
Department of Pediatrics, University of Tennessee Medical Center at Knoxville 37920.

We investigated whether hypermagnesemia alleviates hypoxic or group B streptococcal (GBS) pulmonary hypertension (PH). Hypoxic PH was induced and maintained in 14 lambs by continuous ventilation with 12% oxygen. GBS PH was induced and maintained in 16 lambs by the continuous infusion of 5-10 x 10(8) colony-forming units.kg-1.h-1 of GBS. After the onset of PH, lambs were randomized to receive either magnesium sulfate (MgSO4, intermittent boluses of 0.38 mmol/kg, with a continuous infusion of 0.15 mmol.kg-1.h-1) or a similar volume of normal saline. Hypermagnesemia lowered pulmonary arterial pressure (PAP) and delayed the fall in systemic arterial pressure and stroke volume index seen in the control animals (each P < 0.05). At a serum magnesium concentration ([Mg]) of 2.75 +/- 0.25 mmol/l, PAP was 27 +/- 3 compared with 40 +/- 4 Torr in the control animals ([Mg] = 0.87 +/- 0.06 mmol/l; P < 0.05). In the GBS PH trial, hypermagnesemia prevented the continued increase in PAP seen in the control animals. At [Mg] = 2.15 +/- 0.07 mmol/l, PAP fell 2 +/- 1 Torr from prerandomization values, whereas it rose 4 +/- 2 Torr in the control animals ([Mg] = 0.59 +/- 0.07 mmol/l; P < 0.05). However, during the same time the systemic arterial pressure fell further in the magnesium-treated animals (-19 +/- 1 vs. -2 +/- 5 Torr). MgSO4 attenuates PH in both models but may cause systemic hypotension in sepsis.


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J.-F. Tolsa, Y. Gao, and J. U. Raj
Developmental change in magnesium sulfate-induced relaxation of rabbit pulmonary arteries
J Appl Physiol, November 1, 1999; 87(5): 1589 - 1594.
[Abstract] [Full Text] [PDF]


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