Journal of Applied Physiology AJP: Regulatory, Integrative and Comparative Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 77: 630-640, 1994;
8750-7587/94 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Melchior, F. M.
Right arrow Articles by Clere, J. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Melchior, F. M.
Right arrow Articles by Clere, J. M.

Journal of Applied Physiology, Vol 77, Issue 2 630-640, Copyright © 1994 by American Physiological Society

ARTICLES

Simulation of cardiovascular response to lower body negative pressure from 0 to -40 mmHg

F. M. Melchior, R. S. Srinivasan, P. H. Thullier and J. M. Clere
Laboratoire de Medecine Aerospatiale, Centre d'Essais en Vol, Bretigny sur Orge, France.

This paper presents a mathematical model for simulation of the human cardiovascular response to lower body negative pressure (LBNP) up to -40 mmHg both under normal conditions and when arterial baroreflex sensitivity or leg blood capacity (LBC) is altered. Development of the model assumes that the LBNP response could be explained solely on the bases of 1) blood volume redistribution, 2) left ventricular end-diastolic filling, 3) interaction between left ventricle and peripheral circulation, and 4) modulations of peripheral resistances and heart rate by arterial and cardiopulmonary baroreflexes. The model reproduced well experimental data obtained both under normal conditions and during complete autonomic blockade; thus it is validated for simulation of the cardiovascular response from 0 to -40 mmHg LBNP. We tested the ability of the model to simulate the changes in LBNP response due to a reduction in LBC. To assess these changes experimentally, six healthy men were subjected to LBNP of -15, -30, and -38 mmHg with and without wearing elastic compression stockings. Stockings significantly reduced LBC (from 3.9 +/- 0.3 to 1.8 +/- 0.4 ml/100 ml tissue at -38 mmHg LBNP; P < 0.01) and attenuated the change in heart rate (from 23 +/- 4 to 8 +/- 3% at -38 mmHg LBNP; P < 0.05). The model accurately reproduced this result. The model is useful for assessing the influence of LBC or other parameters such as arterial baroreflex sensitivity in diminishing the orthostatic tolerance of humans after spaceflight, bed rest, or endurance training.


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
M. S. Olufsen, J. T. Ottesen, H. T. Tran, L. M. Ellwein, L. A. Lipsitz, and V. Novak
Blood pressure and blood flow variation during postural change from sitting to standing: model development and validation
J Appl Physiol, October 1, 2005; 99(4): 1523 - 1537.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. Heldt, E. B. Shim, R. D. Kamm, and R. G. Mark
Computational modeling of cardiovascular response to orthostatic stress
J Appl Physiol, March 1, 2002; 92(3): 1239 - 1254.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
E. Magosso and M. Ursino
A mathematical model of CO2 effect on cardiovascular regulation
Am J Physiol Heart Circ Physiol, November 1, 2001; 281(5): H2036 - H2052.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online