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J Appl Physiol 77: 584-589, 1994;
8750-7587/94 $5.00
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Journal of Applied Physiology, Vol 77, Issue 2 584-589, Copyright © 1994 by American Physiological Society

ARTICLES

Interleukin-2 therapy reverses some immunosuppressive effects of skeletal unloading

J. W. Armstrong, S. Balch and S. K. Chapes
Division of Biology, Kansas State University, Manhattan 66506.

Using antiorthostatic suspension, we characterized hematopoietic changes that may be responsible for the detrimental effect of skeletal unloading on macrophage development. Skeletally unloaded mice had suppressed macrophage development in unloaded and loaded bones, which indicated a systemic effect. Bone marrow cells from unloaded mice secreted less macrophage colony-stimulating factor and interleukin-6 than control mice. Additionally, T-lymphocyte proliferation was reduced after skeletal unloading. We show that polyethylene glycol-interleukin-2 therapy reversed the effects of skeletal unloading on macrophage development and cell proliferation.


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