Journal of Applied Physiology, Vol 77, Issue 2 574-583, Copyright © 1994 by American Physiological Society

ARTICLES

Longitudinal distribution of ozone absorption in the lung: effects of respiratory flow

S. C. Hu, A. Ben-Jebria and J. S. Ultman
Department of Chemical Engineering, Pennsylvania State University, University Park 16802.

In our previous work, we developed a bolus inhalation apparatus and measured the longitudinal distribution of ozone (O3) uptake in intact human lungs at a quiet respiratory flow of 250 ml/min. The objective of the present study was to determine the effect of alternative respiratory flows between 150 and 1,000 ml/s. Uptake was expressed as the O3 absorbed during a single breath relative to the amount of O3 in the inhaled bolus (lambda). Measurements of lambda were correlated with the penetration volume of the bolus into the respiratory tract (Vp). Vp in the range of 20-70 ml was considered to indicate upper airways (UA), the Vp interval of 70-180 ml was identified as lower conducting airways (CA), and Vp > 180 ml was associated with the respiratory air spaces (RA). During quiet oral breathing at 250 ml/s, lambda increased smoothly as Vp increased, with 50% of the inhaled O3 absorbed in the UAs and the remainder absorbed within the CAs such that no O3 reached the RAs. The effect of increasing the respiratory flow was to shift the lambda-Vp distribution distally such that significantly less O3 was absorbed in the UAs and CAs and some O3 reached the RAs. For example, at 1,000 ml/s, only 10% of the inhaled O3 was absorbed in UAs and 65% was absorbed in the CAs such that 25% reached the RAs.(ABSTRACT TRUNCATED AT 250 WORDS)

This article has been cited by other articles:

				M. K. Pulfer, C. Taube, E. Gelfand, and R. C. Murphy Ozone Exposure in Vivo and Formation of Biologically Active Oxysterols in the Lung J. Pharmacol. Exp. Ther., January 1, 2005; 312(1): 256 - 264. [Abstract] [Full Text] [PDF]

				L. M. Connor, C. A. Ballinger, T. B. Albrecht, and E. M. Postlethwait Interfacial phospholipids inhibit ozone-reactive absorption-mediated cytotoxicity in vitro Am J Physiol Lung Cell Mol Physiol, June 1, 2004; 286(6): L1169 - L1178. [Abstract] [Full Text] [PDF]

				M. L. Rigas, S. N. Catlin, A. Ben-Jebria, and J. S. Ultman Ozone uptake in the intact human respiratory tract: relationship between inhaled dose and actual dose J Appl Physiol, June 1, 2000; 88(6): 2015 - 2022. [Abstract] [Full Text] [PDF]

				V. Nodelman and J. S. Ultman Longitudinal distribution of chlorine absorption in human airways: a comparison to ozone absorption J Appl Physiol, December 1, 1999; 87(6): 2073 - 2080. [Abstract] [Full Text] [PDF]

				V. Nodelman and J. S. Ultman Longitudinal distribution of chlorine absorption in human airways: comparison of nasal and oral quiet breathing J Appl Physiol, June 1, 1999; 86(6): 1984 - 1993. [Abstract] [Full Text] [PDF]

				E. M. Postlethwait, R. Cueto, L. W. Velsor, and W. A. Pryor O3-induced formation of bioactive lipids: estimated surface concentrations and lining layer effects Am J Physiol Lung Cell Mol Physiol, June 1, 1998; 274(6): L1006 - L1016. [Abstract] [Full Text] [PDF]

				M. SALMON, H. KOTO, O. T. LYNCH, E.-B. HADDAD, N. J. LAMB, G. J. QUINLAN, P. J. BARNES, and K. FAN CHUNG Proliferation of Airway Epithelium After Ozone Exposure . Effect of Apocynin and Dexamethasone Am. J. Respir. Crit. Care Med., March 1, 1998; 157(3): 970 - 977. [Abstract] [Full Text] [PDF]