Journal of Applied Physiology AJP: Gastrointestinal and Liver Physiology
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J Appl Physiol 77: 190-196, 1994;
8750-7587/94 $5.00
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Journal of Applied Physiology, Vol 77, Issue 1 190-196, Copyright © 1994 by American Physiological Society

ARTICLES

Biexponential pulmonary clearance of 99mTc-DTPA induced by detergent aerosol

E. Evander, P. Wollmer, S. Valind, L. Sornmo, J. John and B. Jonson
Department of Clinical Physiology, University of Lund, Malmo, Sweden.

We measured the pulmonary clearance of technetium-99m-labeled diethylenetriamine pentaacetatic acid (99mTc-DTPA) for 3 h after perturbation of the surfactant system by administration of the detergent dioctyl sodium sulfosuccinate in aerosol. Forty-two rabbits were anesthetized with pentobarbital sodium. Tracheostomies were performed, and the rabbits were mechanically ventilated. Increasing concentrations of detergent (0.125-2%) or vehicle were given for 5 min, and clearance measurements were performed immediately or 60 min after detergent administration. No animals developed respiratory distress. After vehicle, the clearance was monoexponential with a half-life of 153 min. Detergent induced a biexponential clearance with a rapidly clearing additional pool of radioactivity with a half-life of 5-15 min. The relative amount of radioactivity clearing rapidly increased with detergent concentration. The detergent effect was partly reversible. We conclude that detergent induces a biexponential clearance of 99mTc-DTPA by accelerating the transfer of tracer across the alveolocapillary barrier in a proportion of lung units in a dose-related manner.


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