Journal of Applied Physiology, Vol 77, Issue 1 160-164, Copyright © 1994 by American Physiological Society

ARTICLES

Effect of age on L-3,5,3'-triiodothyronine-induced ethane exhalation

A. D. Mooradian, M. P. Habib, F. Dickerson and T. Yetskievych
Department of Medicine, St. Louis University Health Sciences Center, Missouri 63104.

The effect of age on thyroid hormone-induced lipid peroxidation in rats was determined by measuring ethane exhalation (EE) rate. The mean basal EE rates (in pmol.min-1 x 100 g-1) at room air in 25-mo-old aged rats [3.07 +/- 0.26 (SE)] and in intermediate age (18-mo-old) rats (3.42 +/- 0.18) were significantly lower than that in young (3- to 5-mo-old) rats (4.44 +/- 0.27) (P < 0.01). After 8 days of L-3,5,3'-triiodothyronine (T3) administration, EE rates in aged rats (4.10 +/- 0.25) and in intermediate-age rats (4.16 +/- 0.35) were significantly lower than that in young rats (5.61 +/- 0.36) (P < 0.01). T3-treated young rats pair-fed with aged rats for 2 wk had EE rates (5.53 +/- 0.18) comparable to ad libitum-fed young rats, although the basal rate of EE was significantly reduced with partial food restriction (4.44 +/- 0.27 vs. 3.50 +/- 0.24) (P < 0.01). These observations indicate that reduced food intake with age cannot account for the age-related changes in T3-stimulated peroxidation rate of lipids.

This article has been cited by other articles:

				A. J. Hulbert, R. Pamplona, R. Buffenstein, and W. A. Buttemer Life and Death: Metabolic Rate, Membrane Composition, and Life Span of Animals Physiol Rev, October 1, 2007; 87(4): 1175 - 1213. [Abstract] [Full Text] [PDF]

				J. Chehade, J. Kim, J. L. Pinnas, and A. D. Mooradian Age-Related Changes in the Thyroid Hormone Effects on Malondialdehyde-Modified Proteins in the Rat Heart Experimental Biology and Medicine, October 2, 1999; 222(1): 59 - 64. [Abstract] [Full Text]