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J Appl Physiol 77: 142-146, 1994;
8750-7587/94 $5.00
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Journal of Applied Physiology, Vol 77, Issue 1 142-146, Copyright © 1994 by American Physiological Society

ARTICLES

Calcitonin gene-related peptide modulates pulmonary vascular reactivity in isolated rat lungs

P. L. Janssen and A. Tucker
Department of Physiology, Colorado State University, Fort Collins 80523.

The role of calcitonin gene-related peptide (CGRP) in modulating hypoxic pulmonary vasoconstriction was assessed. The effects of CGRP and its antagonist [CGRP-(8-37)] on responses to acute hypoxia (3% O2) and angiotensin II (ANG II; 0.4 microgram) were studied in isolated lungs of male Sprague-Dawley rats perfused with a salt solution. Rats with pulmonary hypertension, induced by simulated altitude exposure, were also used to determine the actions of CGRP in a remodeled pulmonary vascular bed. In normotensive (NT) and altitude-exposed (AE) lungs, CGRP injections (10 nM), given after stable pressor responses were attained, attenuated (P < 0.05) subsequent hypoxic pressor responses. Pretreatment with CGRP-(8-37) (10 nM) enhanced (P < or = 0.05) initial ANG II-induced pressor responses in both AE and NT lungs. CGRP-(8-37) pretreatment (10 nM) had little influence on the hypoxic pressor responses in either NT or AE lungs. Results indicate that CGRP modulates hypoxic pulmonary vasoconstriction and that CGRP-(8-37) enhances pressor responses to ANG II in NT and AE rat lungs.


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