Journal of Applied Physiology
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J Appl Physiol 76: 2125-2129, 1994;
8750-7587/94 $5.00
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Journal of Applied Physiology, Vol 76, Issue 5 2125-2129, Copyright © 1994 by American Physiological Society

ARTICLES

Decreased femoral arterial flow during simulated microgravity in the rat

R. D. Roer and R. M. Dillaman
Center for Marine Science Research, University of North Carolina at Wilmington 28403.

To determine whether the blood supply to the hindlimbs of rats is altered by the tail-suspension model of weightlessness, rats were chronically instrumented for the measurement of femoral artery flow. Ultrasonic transit-time flow probes were implanted into 8-wk-old Wistar-Furth rats under ketamine-xylazine anesthesia, and, after 24 h of recovery, flow was measured in the normal ambulatory posture. Next, rats were suspended and flow was measured immediately and then daily over the next 4-7 days. Rats were subsequently returned to normal posture, and flow was monitored daily for 1-3 days. Mean arterial flow decreased immediately on the rats being suspended and continued to decrease until a new steady state of approximately 60% of control values was attained at 5 days. On the rats returning to normal posture, flow increased to levels observed before suspension. Quantile-quantile plots of blood flow data revealed a decrease in flow during both systole and diastole. The observed decrease in hindlimb blood flow during suspension suggests a possible role in the etiology of muscular atrophy and bone loss in microgravity.


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