| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Journal of Applied Physiology, Vol 76, Issue 5 1922-1927, Copyright © 1994 by American Physiological Society
ARTICLES |
J. M. Hansen, N. V. Olsen, B. Feldt-Rasmussen, I. L. Kanstrup, M. Dechaux, C. Dubray and J. P. Richalet
Department of Nephrology, Herlev Hospital, University of Copenhagen, Denmark.
The mechanism of proteinuria at high altitude is unclear. Renal function and urinary excretion rate of albumin (Ualb) at rest and during submaximal exercise and transcapillary escape rate of 125I-labeled albumin (TERalb) were investigated in 12 normal volunteers at sea level and after rapid and passive ascent to 4,350 m. The calcium antagonist isradipine (5 mg/day; n = 6) or placebo (n = 6) was administered to abolish hypoxia-induced rises in blood pressure. Lithium clearance and urinary excretion of beta 2-microglobulin were used to evaluate renal tubular function. High altitude increased Ualb from 2.8 to > 5.0 micrograms/min in both groups (P < 0.05). In the placebo group, high altitude significantly increased filtration fraction (P < 0.05), but this response was abolished by isradipine. Lithium clearance and urinary excretion of beta 2-microglobulin remained unchanged by hypoxia in both groups. Exercise did not reveal any further renal dysfunction. In both groups, high altitude increased TERalb from 4.8 to > 6.7%/h (P < 0.05). In conclusion, acute altitude hypoxia increases Ualb despite unchanged tubular function and independent of effects of isradipine on filtration fraction. The elevated TERalb suggests an overall increase in capillary permeability, including the glomerular endothelium, as the critical factor in high-altitude induced albuminuria.
This article has been cited by other articles:
|
|
 |
|
  M. Vargas, E. Vargas, C. G. Julian, J. F. Armaza, A. Rodriguez, W. Tellez, S. Niermeyer, M. Wilson, E. Parra, M. Shriver, et al. Determinants of blood oxygenation during pregnancy in Andean and European residents of high altitude Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2007; 293(3): R1303 - R1312. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. J. Gore, W. G. Hopkins, and C. M. Burge Errors of measurement for blood volume parameters: a meta-analysis J Appl Physiol, November 1, 2005; 99(5): 1745 - 1758. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Loeppky, M. V. Icenogle, D. Maes, K. Riboni, H. Hinghofer-Szalkay, and R. C. Roach Early fluid retention and severe acute mountain sickness J Appl Physiol, February 1, 2005; 98(2): 591 - 597. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Cogo, A. Ciaccia, C. Legorini, A. Grimaldi, G. Milani, J.-L. Vincent, and O. Abid Proteinuria in COPD Patients With and Without Respiratory Failure Chest, February 1, 2003; 123(2): 652 - 653. [Full Text] [PDF]
|
|
|
|
 |
|
 P. Tassani, H. Schad, C. Winkler, A. Bernhard, U. Ettner, S. L. Braun, G. P. Eising, E. Kochs, R. Lange, and J. A. Richter Capillary leak syndrome after cardiopulmonary bypass in elective, uncomplicated coronary artery bypass grafting operations: Does it exist? J. Thorac. Cardiovasc. Surg., April 1, 2002; 123(4): 735 - 741. [Abstract] [Full Text]
|
|
|
|
 |
|
 R. Pedrinelli, G. Dell'Omo, G. Penno, and M. Mariani Non-diabetic microalbuminuria, endothelial dysfunction and cardiovascular disease Vascular Medicine, November 1, 2001; 6(4): 257 - 264. [Abstract] [PDF]
|
|
|
|
 |
|
 T. C. Carpenter and K. R. Stenmark Hypoxia decreases lung neprilysin expression and increases pulmonary vascular leak Am J Physiol Lung Cell Mol Physiol, October 1, 2001; 281(4): L941 - L948. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Miserocchi, A. Passi, D. Negrini, M. Del Fabbro, and G. De Luca Pulmonary interstitial pressure and tissue matrix structure in acute hypoxia Am J Physiol Lung Cell Mol Physiol, May 1, 2001; 280(5): L881 - L887. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Imoberdorf, P. J. Garlick, M. A. McNurlan, G. A. Casella, E. Peheim, M. Turgay, P. Bartsch, and P. E. Ballmer Enhanced synthesis of albumin and fibrinogen at high altitude J Appl Physiol, February 1, 2001; 90(2): 528 - 537. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Galatius, L. Bent-Hansen, H. Wroblewski, V. B. Sorensen, T. Norgaard, and J. Kastrup Plasma Disappearance of Albumin and Impact of Capillary Thickness in Idiopathic Dilated Cardiomyopathy and After Heart Transplantation Circulation, July 18, 2000; 102(3): 319 - 325. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Robach, M. Dechaux, S. Jarrot, J. Vaysse, J.-C. Schneider, N. P. Mason, J.-P. Herry, B. Gardette, and J.-P. Richalet Operation Everest III: role of plasma volume expansion on VO2max during prolonged high-altitude exposure J Appl Physiol, July 1, 2000; 89(1): 29 - 37. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Maloney, D. Wang, T. Duncan, N. Voelkel, and S. Ruoss Plasma Vascular Endothelial Growth Factor in Acute Mountain Sickness Chest, July 1, 2000; 118(1): 47 - 52. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Pedrinelli, G. Penno, G. Dell'Omo, S. Bandinelli, D. Giorgi, V. Di Bello, R. Navalesi, and M. Mariani Microalbuminuria and Transcapillary Albumin Leakage in Essential Hypertension Hypertension, September 1, 1999; 34(3): 491 - 495. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. H. Bestle, N. V. Olsen, T. D. Poulsen, R. Roach, N. Fogh-Andersen, and P. Bie Prolonged hypobaric hypoxemia attenuates vasopressin secretion and renal response to osmostimulation in men J Appl Physiol, May 1, 2002; 92(5): 1911 - 1922. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
