Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 76: 1130-1137, 1994;
8750-7587/94 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kilbourn, R. G.
Right arrow Articles by Griffith, O. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kilbourn, R. G.
Right arrow Articles by Griffith, O. W.

Journal of Applied Physiology, Vol 76, Issue 3 1130-1137, Copyright © 1994 by American Physiological Society

ARTICLES

NG-methyl-L-arginine, an inhibitor of nitric oxide formation, reverses IL-2-mediated hypotension in dogs

R. G. Kilbourn, L. B. Owen-Schaub, D. M. Cromeens, S. S. Gross, M. J. Flaherty, S. M. Santee, A. M. Alak and O. W. Griffith
Department of Genitourinary Medical Oncology, University of Texas M. D. Anderson Cancer Center, Houston 77030.

The effects of NG-methyl-L-arginine (L-NMA), an inhibitor of nitric oxide formation, were studied in dogs treated with interleukin-2 (IL-2). The administration of IL-2 to dogs resulted in hypotension within 3 days of treatment. The development of hypotension correlated with accumulation in the serum of nitrate, which is a stable breakdown product of nitric oxide. Administration of L-NMA decreased serum nitrate levels and increased the mean arterial pressure. The antihypotensive effect was dose dependent with a maximum effect observed at a dose of 20 mg/kg. Administration of a continuous infusion of L-NMA (5 mg.kg-1.h-1) maintained the mean arterial pressure for 48 h with concurrent administration of IL-2. Evaluation of IL-2-induced lymphokine-activated killer cell proliferation and tumoricidal activity toward a canine glioblastoma target cell line was unaffected by L-NMA. These studies imply that L-NMA may effectively ameliorate the dose-limiting hypotension associated with administration of IL-2 without adversely affecting the antitumor effects.


This article has been cited by other articles:


Home page
 Cardiovasc ResHome page
V. W.T. Liu and P. L. Huang
Cardiovascular roles of nitric oxide: A review of insights from nitric oxide synthase gene disrupted mice
Cardiovasc Res, January 1, 2008; 77(1): 19 - 29.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
M.-F. Doursout, P. M. Joseph, Y. Y. Liang, C. J. Hartley, and J. E. Chelly
Role of propofol and its solvent, intralipid, in nitric oxide-induced peripheral vasodilatation in dogs
Br. J. Anaesth., September 1, 2002; 89(3): 492 - 498.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
J. L. Hornick, L. A. Khawli, P. Hu, J. Sharifi, C. Khanna, and A. L. Epstein
Pretreatment with a Monoclonal Antibody/Interleukin-2 Fusion Protein Directed against DNA Enhances the Delivery of Therapeutic Molecules to Solid Tumors
Clin. Cancer Res., January 1, 1999; 5(1): 51 - 60.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
B. R. Babu and O. W. Griffith
N5-(1-Imino-3-butenyl)-L-ornithine. A NEURONAL ISOFORM SELECTIVE MECHANISM-BASED INACTIVATOR OF NITRIC OXIDE SYNTHASE
J. Biol. Chem., April 10, 1998; 273(15): 8882 - 8889.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online