Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 76: 1082-1087, 1994;
8750-7587/94 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by O'Connell, F.
Right arrow Articles by Karlsson, J. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by O'Connell, F.
Right arrow Articles by Karlsson, J. A.

Journal of Applied Physiology, Vol 76, Issue 3 1082-1087, Copyright © 1994 by American Physiological Society

ARTICLES

Effect of clonidine on induced cough and bronchoconstriction in guinea pigs and healthy humans

F. O'Connell, V. E. Thomas, R. W. Fuller, N. B. Pride and J. A. Karlsson
Department of Clinical Pharmacology, Royal Postgraduate Medical School, London, United Kingdom.

We examined the effects of the alpha 2-receptor agonist clonidine, administered orally and by inhalation, on citric acid- and capsaicin-induced reflexes in guinea pigs and healthy human subjects. In groups (n = 8-10) of conscious guinea pigs, oral clonidine (10 and 100 micrograms/kg) was without effects, whereas inhaled clonidine (10-1,000 microM) caused a concentration-dependent inhibition of citric acid-induced cough (coughs during 3 min: control, 6.5 +/- 0.9; 1,000 microM clonidine, 1.7 +/- 1.0; P < 0.05) and reflex bronchoconstriction (time to onset of bronchoconstriction: control, 191 +/- 24 s; 1,000 microM clonidine, 317 +/- 33 s; P < 0.05). The inhibitory effect of inhaled clonidine on both reflexes was completely reversed by pretreatment with yohimbine but not with prazosin. In 12 healthy human volunteers, oral clonidine (150 mg) caused a significant fall in supine and erect systolic blood pressure and a significant increase in drowsiness as measured on a visual analogue scale 1 and 2 h after administration. Despite these effects, oral clonidine had no effect on capsaicin-induced cough or reflex bronchoconstriction in humans. In contrast to the effects in guinea pigs, inhaled clonidine (281 microM) had no effect on capsaicin-induced cough or reflex bronchoconstriction in humans. These data suggest that peripheral alpha 2-receptors exert an inhibitory effect on sensory neurotransmission in the guinea pig but not in the healthy human airway, indicating an important difference between the two species.


This article has been cited by other articles:


Home page
 Eur Respir JHome page
P. V. Dicpinigaitis, B. Sitkauskiene, K. Stravinskaite, D. W. Appel, A. Negassa, and R. Sakalauskas
Effect of smoking cessation on cough reflex sensitivity
Eur. Respir. J., October 1, 2006; 28(4): 786 - 790.
[Abstract] [Full Text] [PDF]

Home page
 Canadian J. AnesthesiaHome page
T. Oshima, Y. Kasuya, Y. Okumura, T. Murakami, and S. Dohi
Identification of independent risk factors for fentanyl-induced cough: [L'identification de facteurs de risque independants pour la toux induite par le fentanyl].
Can J Anesth, August 1, 2006; 53(8): 753 - 758.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
P. V. Dicpinigaitis and R. V. Alva
Safety of Capsaicin Cough Challenge Testing
Chest, July 1, 2005; 128(1): 196 - 202.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
M. Arimitsu, M. Mitsui-Saito, K. Sato, H. Ozaki, Y. Koga, and H. Karaki
Mechanism of Relaxant Effect of Clonidine in Isolated Bovine Tracheal Smooth Muscle
J. Pharmacol. Exp. Ther., August 1, 1998; 286(2): 681 - 687.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online