Journal of Applied Physiology
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J Appl Physiol 76: 1043-1048, 1994;
8750-7587/94 $5.00
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Journal of Applied Physiology, Vol 76, Issue 3 1043-1048, Copyright © 1994 by American Physiological Society

ARTICLES

Effects of acute caffeine withdrawal on habituated male runners

R. K. Hetzler, N. Warhaftig-Glynn, D. L. Thompson, E. Dowling and A. Weltman
Department of Human Services, Curry School of Education, University of Virginia, Charlottesville 22903.

This study investigated the effects of caffeine withdrawal on six trained caffeine-habituated male runners: age 29.8 +/- 5.8 (SD) yr, height 180.4 +/- 5.4 cm, weight 77.3 +/- 6.7 kg, maximal O2 uptake 63.0 +/- 5.4 ml.kg-1.min-1, and daily caffeine intake 674 +/- 128 mg. The subjects received a loading dose (5 mg/kg body wt) of caffeine 48 h before each testing session. They were then given (using a repeated-measures double-blind design) additional doses of caffeine (5 mg/kg body wt) or a placebo 36, 24, 12, and 2 h before testing. They ran at a velocity corresponding to their lactate threshold for 60 min in a caffeine withdrawal or caffeinated condition. Caffeine withdrawal resulted in no significant differences in absolute O2 uptake, O2 uptake relative to maximal O2 uptake, respiratory exchange ratios, or free fatty acid concentrations. Glycerol concentrations were significantly attenuated in the withdrawal condition. No significant differences were revealed in calculated substrate utilization. It was concluded that caffeine withdrawal significantly affects lipolysis but not substrate utilization during prolonged running.


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M. H. Van Soeren and T. E. Graham
Effect of caffeine on metabolism, exercise endurance, and catecholamine responses after withdrawal
J Appl Physiol, October 1, 1998; 85(4): 1493 - 1501.
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