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Journal of Applied Physiology, Vol 76, Issue 2 694-700, Copyright © 1994 by American Physiological Society
ARTICLES |
J. Dupuis, C. A. Goresky and D. J. Stewart
McGill University Medical Clinic, Montreal General Hospital, Quebec, Canada.
The single-bolus multiple-indicator-dilution technique was used to evaluate pulmonary removal of tracer 125I-labeled endothelin-1 in seven anesthetized dogs. Simultaneously, pulmonary arterial and aortic blood samples were obtained and assayed to determine the levels of immunoreactive endothelin-1. When 125I-endothelin-1 was compared with a plasma vascular reference (Evans blue dye), there was a single passage mean extraction of 31 +/- 8%. In contrast, there was no significant difference between immunoreactive endothelin-1 levels measured in blood samples from the pulmonary artery and the aorta (1.26 +/- 0.58 and 1.37 +/- 0.50 pg/ml, respectively; P = 0.47). The absence of an arteriovenous difference for bulk endothelin-1 across the lungs in the presence of tracer data indicating a substantial uptake implies that an amount of endothelin-1 quantitatively more or less equal to that removed is produced by the lung. The shapes of the dilution curves suggest that the tracer endothelin uptake by the lung is a one-way process without vascular reentry of tracer. We conclude that the dog lung is an important site for both uptake and release of endothelin-1.
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H. Kjekshus, O. A. Smiseth, R. Klinge, E. Oie, M. E. Hystad, and H. Attramadal Regulation of ET: pulmonary release of ET contributes to increased plasma ET levels and vasoconstriction in CHF Am J Physiol Heart Circ Physiol, April 1, 2000; 278(4): H1299 - H1310. [Abstract] [Full Text] [PDF]
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J. Dupuis, G. W Moe, and P. Cernacek Reduced pulmonary metabolism of endothelin-1 in canine tachycardia-induced heart failure Cardiovasc Res, September 1, 1998; 39(3): 609 - 616. [Abstract] [Full Text] [PDF]
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 S. Prié, T. K. Leung, P. Cernacek, J. W. Ryan, and J. Dupuis The Orally Active ETA Receptor Antagonist (+)-(S)-2-(4,6-dimethoxy-pyrimidin-2-yloxy)-3-methoxy-3,3-diphenyl-propionic acid (LU 135252) Prevents the Development of Pulmonary Hypertension and Endothelial Metabolic Dysfunction in Monocrotaline-Treated Rats J. Pharmacol. Exp. Ther., September 1, 1997; 282(3): 1312 - 1318. [Abstract] [Full Text]
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J. Dupuis, D. J. Stewart, P. Cernacek, and G. Gosselin Human Pulmonary Circulation Is an Important Site for Both Clearance and Production of Endothelin-1 Circulation, October 1, 1996; 94(7): 1578 - 1584. [Abstract] [Full Text]
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