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J Appl Physiol 76: 641-649, 1994;
8750-7587/94 $5.00
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Journal of Applied Physiology, Vol 76, Issue 2 641-649, Copyright © 1994 by American Physiological Society

ARTICLES

Cardiac and plasma atrial natriuretic peptide after 9-day hindlimb suspension in rats

J. Fareh, B. Bayard, J. Gabrion, G. Thibault, J. Oliver, C. Bouille, G. Gauquelin and C. Gharib
Laboratoire de Physiologie de l'Environment, Faculte de Medecine Lyon Grange, Blanche, Lyon, France.

To determine atrial natriuretic peptide (ANP) adaptation to simulated weightlessness, immunoreactive plasma (ir-NH2- and ir-COOH-terminals) and atrial (ir-COOH-terminal) ANP levels, atrial mRNA expression, immunoreactive cardiocyte ANP levels (ir-NH2- and ir-COOH-terminals), and ultrastructural observations of granules in atrial cardiocytes were assessed in male Wistar rats after a 9-day hindlimb suspension. Plasma ir-NH2- and ir-COOH-terminal ANP concentrations decreased by 17 (P < 0.05) and 37% (P < 0.05), respectively, in suspended rats. A concomitant ir-COOH-terminal ANP content reduction was also observed in left (31%; P < 0.01) and right atria (25%; P < 0.05). Atrial ANP mRNA expression was severely depleted in the right atrium and less so in the left atrium after 9 days of hindlimb suspension. Immunocytochemistry observations demonstrated lowered NH2- and COOH-terminal ANP immunoreactivities in left and right atria from suspended rats. A reduced number of storage granules (dense granules) in both atria was also noted on ultrastructural analysis. It was concluded that ANP biosynthesis, storage, and release were decreased after a 9-day hindlimb suspension.


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