Journal of Applied Physiology AJP: Lung Cellular and Molecular Physiology
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J Appl Physiol 76: 291-302, 1994;
8750-7587/94 $5.00
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Journal of Applied Physiology, Vol 76, Issue 1 291-302, Copyright © 1994 by American Physiological Society

ARTICLES

Regional effects of myocardial ischemia on epicardially recorded canine first heart sounds

J. C. Wood, M. P. Festen, M. J. Lim, A. J. Buda and D. T. Barry
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor 48109.

To determine whether focal changes in myocardial material properties are important in determining the response of first heart sound acceleration amplitude and frequency to myocardial ischemia, cardiac vibrations were simultaneously recorded from ischemic and nonischemic regions of canine epicardium by use of ultralight acceleration transducers. Cardiac acceleration and hemodynamics were recorded before and 5 min, 15 min, 1 h, and 2 h after left circumflex coronary artery occlusion. Peak-to-peak amplitude declined transiently in the nonischemic zone during early occlusion (P < 0.05) but was not decreased at any time in the ischemic myocardium. The median frequency of first heart sound vibrations in the ischemic region increased 31% within 5 min after occlusion (P < 0.01) and remained elevated for 2 h (P < 0.05). Nonischemic zone frequency was not statistically different from baseline at any time point. The disparate regional response of first heart sound vibrational frequency to myocardial ischemia suggests that propagating mechanical transients and myocardial contractile acceleration, rather than resonant vibrations, produce the first heart sound.


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