| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Journal of Applied Physiology, Vol 76, Issue 1 259-265, Copyright © 1994 by American Physiological Society
ARTICLES |
D. B. Pearse and E. M. Wagner
Division of Pulmonary and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland 21224.
Bronchial arterial (BA) perfusion could modify pulmonary arterial (PA) ischemia-reperfusion (IR) injury by promoting clearance of peribronchial edema or limiting edema formation through maintenance of pulmonary vessel integrity via bronchopulmonary anastomotic or pulmonary vasa vasorum flow. The purpose of this study was to determine the effect of BA perfusion on IR injury in isolated sheep lungs. In 12 lungs (BA++) the BA was perfused throughout 30 min of PA ischemia and 180 min of reperfusion. In 12 lungs (BA-+) BA perfusion was begun with PA reperfusion, and in 15 lungs (BA--) the BA was never perfused. After 180 min, extravascular lung water was less (P < 0.05) in BA++ and B-+ lungs [4.70 +/- 0.16 and 4.57 +/- 0.18 g/g blood-free dry lung (bfdl)] than in BA-- lungs (5.23 +/- 0.19 g/g bfdl). The reflection coefficient for albumin was greater (P < 0.05) in BA++ and BA-+ (0.57 +/- 0.06 and 0.75 +/- 0.03) than in BA-- lungs (0.44 +/- 0.04). The filtration coefficient in BA++ and BA-+ lungs (0.016 +/- 0.006 and 0.015 +/- 0.006 g.min-1 x mmHg-1 x kg-1) was not different from that in BA-- lungs (0.025 +/- 0.006 g.min-1 x mmHg-1 x kg-1). These results suggest that BA perfusion decreased reperfusion edema by attenuating the increase in pulmonary vascular permeability caused by IR injury. Moreover the result in BA-+ lungs suggests that the protective effect was mediated by BA perfusion of PA vasa vasorum rather than bronchopulmonary anastomotic flow, which was trivial compared with PA blood flow.
This article has been cited by other articles:
|
|
 |
|
  A. Della Corte, M. Scardone, G. Romano, C. Amarelli, A. Biondi, L. S. De Santo, M. De Feo, G. Nappi, and M. Cotrufo Aortic Arch Surgery: Thoracoabdominal Perfusion During Antegrade Cerebral Perfusion May Reduce Postoperative Morbidity Ann. Thorac. Surg., April 1, 2006; 81(4): 1358 - 1364. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Mitzner and E. M. Wagner Vascular remodeling in the circulations of the lung J Appl Physiol, November 1, 2004; 97(5): 1999 - 2004. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Dodd-o, L. E. Welsh, J. D. Salazar, P. L. Walinsky, E. A. Peck, J. G. Shake, D. J. Caparrelli, B. T. Bethea, S. M. Cattaneo, W. A. Baumgartner, et al. Effect of bronchial artery blood flow on cardiopulmonary bypass-induced lung injury Am J Physiol Heart Circ Physiol, February 1, 2004; 286(2): H693 - H700. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Dodd-o, M. L. Hristopoulos, N. Faraday, and D. B. Pearse Effect of ischemia and reperfusion without airway occlusion on vascular barrier function in the in vivo mouse lung J Appl Physiol, November 1, 2003; 95(5): 1971 - 1978. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. NOWAK, M. KAMLER, M. BOCK, J. MOTSCH, S. HAGL, H. JAKOB, and M.-M. GEBHARD Bronchial Artery Revascularization Affects Graft Recovery after Lung Transplantation Am. J. Respir. Crit. Care Med., January 15, 2002; 165(2): 216 - 220. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Minamiya, K. Tozawa, M. Kitamura, S. Saito, and J.-i. Ogawa Platelet-activating Factor Mediates Intercellular Adhesion Molecule-1-dependent Radical Production in the Nonhypoxic Ischemia Rat Lung Am. J. Respir. Cell Mol. Biol., July 1, 1998; 19(1): 150 - 157. [Abstract] [Full Text]
|
|
|
|
|
|
E. FADEL, G.-M. MAZMANIAN, A. CHAPELIER, B. BAUDET, H. DETRUIT, V. de MONTPREVILLE, J.-M. LIBERT, M. WARTSKI, P. HERVE, and P. DARTEVELLE Lung Reperfusion Injury after Chronic or Acute Unilateral Pulmonary Artery Occlusion Am. J. Respir. Crit. Care Med., April 1, 1998; 157(4): 1294 - 1300. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. B. Pearse, T. E. Dahms, and E. M. Wagner Microsphere-induced bronchial artery vasodilation: role of adenosine, prostacyclin, and nitric oxide Am J Physiol Heart Circ Physiol, March 1, 1998; 274(3): H760 - H768. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. Herold, H. Jakob, M. Kamler, R. Thiele, U. Tochtermann, J. Weinmann, J. Motsch, M. M. Gebhard, and S. Hagl Interruption of bronchial circulation leads to a severe decrease in peribronchial oxygen tension in standard lung transplantation technique Eur. J. Cardiothorac. Surg., February 1, 1998; 13(2): 176 - 183. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Norgaard, F. Efsen, C. B. Andersen, U. G. Svendsen, and G. Pettersson MEDIUM-TERM PATENCY AND ANATOMIC CHANGES AFTER DIRECT BRONCHIAL ARTERY REVASCULARIZATION IN LUNG AND HEART-LUNG TRANSPLANTATION WITH THE INTERNAL THORACIC ARTERY CONDUIT J. Thorac. Cardiovasc. Surg., September 1, 1997; 114(3): 326 - 331. [Abstract] [Full Text]
|
|
|
|
|
|
B. A. Simon, P. B. Zanaboni, and D. P. Nyhan Effect of hypoxia on respiratory system impedance in dogs J Appl Physiol, August 1, 1997; 83(2): 451 - 458. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Norgaard, P. S. Olsen, U. G. Svendsen, and G. Pettersson Revascularization of the Bronchial Arteries in Lung Transplantation: An Overview Ann. Thorac. Surg., October 1, 1996; 62(4): 1215 - 1221. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
