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J Appl Physiol 76: 138-145, 1994;
8750-7587/94 $5.00
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Journal of Applied Physiology, Vol 76, Issue 1 138-145, Copyright © 1994 by American Physiological Society

ARTICLES

Evaluation of perilla ketone-induced unilateral lung injury using external gamma scanning

V. J. Abernathy, N. A. Pou, R. E. Parker and R. J. Roselli
Department of Biomedical Engineering, School of Engineering, Vanderbilt University, Nashville, Tennessee 37235.

We used a modified external gamma scanning technique to quantitate right and left lung permeability changes to iodinated sheep albumin before and after perilla ketone (PK)-mediated unilateral lung injury in seven anesthetized sheep. Three portable gamma scintillation probes containing 2-in. NaI crystals detected radioactivities of 51Cr-labeled red blood cells and 125I-labeled albumin over the right and left lungs and blood, respectively. Radioactivities were monitored for 1 h before and 3 h after infusion of 25 mg/kg PK into a single lung. Calculation of normalized slope index (NSI) (Roselli and Riddle, J. Appl. Physiol. 67: 2343-2350, 1989) over the 30-min interval before PK and over the 60- to 90-min interval after PK for each lung revealed a four- to five-fold NSI increase in lungs receiving PK (0.00237 +/- 0.00065 to 0.0109 +/- 0.0016 min-1) and no increase in contralateral control lungs (0.00214 +/- 0.00065 to 0.00201 +/- 0.00032 min-1). Observed changes in NSI were consistent with postmortem evaluations of each lung. Lungs receiving PK had significantly higher wet-to-dry lung weight ratios and extravascular lung water volumes than contralateral control lungs. Measured bloodless wet-to-dry lung weight ratios were 5.68 +/- 0.39 and 3.27 +/- 0.27 (P < 0.05) for PK and control lungs, respectively.


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Neutral and DEAE dextrans as tracers for assessing lung microvascular barrier permeability and integrity
J Appl Physiol, July 1, 2002; 93(1): 251 - 262.
[Abstract] [Full Text] [PDF]


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