Journal of Applied Physiology AJP citation statistics
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 75: 2117-2124, 1993;
8750-7587/93 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wheatley, J. R.
Right arrow Articles by White, D. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wheatley, J. R.
Right arrow Articles by White, D. P.

Journal of Applied Physiology, Vol 75, Issue 5 2117-2124, Copyright © 1993 by American Physiological Society

ARTICLES

Influence of sleep on response to negative airway pressure of tensor palatini muscle and retropalatal airway

J. R. Wheatley, D. J. Tangel, W. S. Mezzanotte and D. P. White
Pulmonary Division, Denver Veterans Administration Medical Center, National Jewish Center for Immunology and Respiratory Medicine, Colorado.

Increased retropalatal airway resistance may be caused by a sleep-induced loss of palatal muscle activity and a diminished ability of these muscles to respond to the increasing intrapharyngeal negative pressure that develops during sleep. To investigate these possibilities, in six normal subjects, we determined the effect of non-rapid-eye-movement sleep on 1) the tensor palatini (TP) electromyogram (EMG) response to rapid-onset negative-pressure generations (NPG) in the upper airway and 2) the collapsibility of the retropalatal airway during these NPGs. During wakefulness, the change in TP EMG from basal to peak levels (during NPG) was 19.8 +/- 3.2 arbitrary units (P < 0.005). This was markedly reduced during sleep (3.6 +/- 1.5 arbitrary units; P < 0.001). The latency of the TP EMG response was 48.5 +/- 5.6 ms during wakefulness but was prolonged during sleep (105.0 +/- 12.2 ms; P < 0.02). The peak transpalatal pressure during NPG (a measure of airway collapse) was 2.1 +/- 0.7 cmH2O during wakefulness and increased to 5.3 +/- 0.8 cmH2O during sleep (P < 0.05). We conclude that the brisk reflex response of the TP muscle to negative pressure during wakefulness is markedly reduced during non-rapid-eye-movement sleep, in association with a more collapsible retropalatal airway. We speculate that the reduction in this TP reflex response contributes to retropalatal airway narrowing during sleep in normal subjects.


This article has been cited by other articles:


Home page
 J. Neurophysiol.Home page
E. F. Bailey, K. W. Fridel, and A. D. Rice
Sleep/Wake Firing Patterns of Human Genioglossus Motor Units
J Neurophysiol, December 1, 2007; 98(6): 3284 - 3291.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
A. S Jordan, A. Wellman, R. C Heinzer, Y.-L. Lo, K. Schory, L. Dover, S. Gautam, A. Malhotra, and D. P White
Mechanisms used to restore ventilation after partial upper airway collapse during sleep in humans
Thorax, October 1, 2007; 62(10): 861 - 867.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
E. F. Bailey, Y.-H. Huang, and R. F. Fregosi
Anatomic consequences of intrinsic tongue muscle activation
J Appl Physiol, November 1, 2006; 101(5): 1377 - 1385.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
D. P. White
Pathogenesis of Obstructive and Central Sleep Apnea
Am. J. Respir. Crit. Care Med., December 1, 2005; 172(11): 1363 - 1370.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. C. Heinzer, M. L. Stanchina, A. Malhotra, R. B. Fogel, S. R. Patel, A. S. Jordan, K. Schory, and D. P. White
Lung Volume and Continuous Positive Airway Pressure Requirements in Obstructive Sleep Apnea
Am. J. Respir. Crit. Care Med., July 1, 2005; 172(1): 114 - 117.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. M. O'Driscoll, K. Kostikas, A. K. Simonds, and M. J. Morrell
Occlusion of the upper airway does not augment the cardiovascular response to arousal from sleep in humans
J Appl Physiol, April 1, 2005; 98(4): 1349 - 1355.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. L. Marcus, L. B. Fernandes Do Prado, J. Lutz, E. S. Katz, C. A. Black, P. Galster, and K. A. Carson
Developmental changes in upper airway dynamics
J Appl Physiol, July 1, 2004; 97(1): 98 - 108.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. Younes
Role of Arousals in the Pathogenesis of Obstructive Sleep Apnea
Am. J. Respir. Crit. Care Med., March 1, 2004; 169(5): 623 - 633.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. Younes
Contributions of Upper Airway Mechanics and Control Mechanisms to Severity of Obstructive Apnea
Am. J. Respir. Crit. Care Med., September 15, 2003; 168(6): 645 - 658.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. B. Berry, D. P. White, J. Roper, G. Pillar, R. B. Fogel, M. Stanchina, and A. Malhotra
Awake negative pressure reflex response of the genioglossus in OSA patients and normal subjects
J Appl Physiol, May 1, 2003; 94(5): 1875 - 1882.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. Ryan, W. T. McNicholas, R. G. O'Regan, and P. Nolan
Upper airway muscle paralysis reduces reflex upper airway motor response to negative transmural pressure in rat
J Appl Physiol, April 1, 2003; 94(4): 1307 - 1316.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. R. Feroah, H. V. Forster, L. Pan, N. E. Schlick, P. Martino, and T. Rice
Negative pressure effects on mechanically opposing pharyngeal muscles in awake and sleeping goats
J Appl Physiol, November 1, 2001; 91(5): 2289 - 2297.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
A. Malhotra, G. Pillar, R. Fogel, J. Beauregard, J. Edwards, and D. P. White
Upper-Airway Collapsibility : Measurements and Sleep Effects
Chest, July 1, 2001; 120(1): 156 - 161.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G. W. Don, T. Kirjavainen, C. Broome, C. Seton, and K. A. Waters
Site and mechanics of spontaneous, sleep-associated obstructive apnea in infants
J Appl Physiol, December 1, 2000; 89(6): 2453 - 2462.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
G. PILLAR, A. MALHOTRA, R. FOGEL, J. BEAUREGARD, R. SCHNALL, and D. P. WHITE
Airway Mechanics and Ventilation in Response to Resistive Loading during Sleep . Influence of Gender
Am. J. Respir. Crit. Care Med., November 1, 2000; 162(5): 1627 - 1632.
[Abstract] [Full Text]

Home page
 J. Appl. Physiol.Home page
G. Pillar, A. Malhotra, R. B. Fogel, J. Beauregard, D. I. Slamowitz, S. A. Shea, and D. P. White
Upper airway muscle responsiveness to rising PCO2 during NREM sleep
J Appl Physiol, October 1, 2000; 89(4): 1275 - 1282.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. MALHOTRA, G. PILLAR, R. B. FOGEL, J. BEAUREGARD, J. K. EDWARDS, D. I. SLAMOWITZ, S. A. SHEA, and D. P. WHITE
Genioglossal But Not Palatal Muscle Activity Relates Closely to Pharyngeal Pressure
Am. J. Respir. Crit. Care Med., September 1, 2000; 162(3): 1058 - 1062.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. A. SHEA, T. AKAHOSHI, J. K. EDWARDS, and D. P. WHITE
Influence of Chemoreceptor Stimuli on Genioglossal Response to Negative Pressure in Humans
Am. J. Respir. Crit. Care Med., August 1, 2000; 162(2): 559 - 565.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. Worsnop, A. Kay, Y. Kim, J. Trinder, and R. Pierce
Effect of age on sleep onset-related changes in respiratory pump and upper airway muscle function
J Appl Physiol, May 1, 2000; 88(5): 1831 - 1839.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. MALHOTRA, R. B. FOGEL, J. K. EDWARDS, S. A. SHEA, and D. P. WHITE
Local Mechanisms Drive Genioglossus Activation in Obstructive Sleep Apnea
Am. J. Respir. Crit. Care Med., May 1, 2000; 161(5): 1746 - 1749.
[Abstract] [Full Text]

Home page
 Arch Otolaryngol Head Neck SurgHome page
A. J. McWhorter, J. A. Rowley, D. W. Eisele, P. L. Smith, and A. R. Schwartz
The Effect of Tensor Veli Palatini Stimulation on Upper Airway Patency
Arch Otolaryngol Head Neck Surg, September 1, 1999; 125(9): 937 - 940.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
F. SERIES, C. COTE, and S. ST. PIERRE
Dysfunctional Mechanical Coupling of Upper Airway Tissues in Sleep Apnea Syndrome
Am. J. Respir. Crit. Care Med., May 1, 1999; 159(5): 1551 - 1555.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. C. Amis, N. O'Neill, J. R. Wheatley, T. van der Touw, E. di Somma, and A. Brancatisano
Soft palate muscle responses to negative upper airway pressure
J Appl Physiol, February 1, 1999; 86(2): 523 - 530.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
F. J. TRUDO, W. B. GEFTER, K. C. WELCH, K. B. GUPTA, G. MAISLIN, and R. J. SCHWAB
State-related Changes in Upper Airway Caliber and Surrounding Soft-Tissue Structures in Normal Subjects
Am. J. Respir. Crit. Care Med., October 1, 1998; 158(4): 1259 - 1270.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. Worsnop, A. Kay, R. Pierce, Y. Kim, and J. Trinder
Activity of respiratory pump and upper airway muscles during sleep onset
J Appl Physiol, September 1, 1998; 85(3): 908 - 920.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
D. FRIBERG, T. ANSVED, K. BORG, B. CARLSSON-NORDLANDER, H. LARSSON, and E. SVANBORG
Histological Indications of a Progressive Snorers Disease in an Upper Airway Muscle
Am. J. Respir. Crit. Care Med., February 1, 1997; 157(2): 586 - 593.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online