Journal of Applied Physiology
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J Appl Physiol 75: 1974-1979, 1993;
8750-7587/93 $5.00
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Journal of Applied Physiology, Vol 75, Issue 5 1974-1979, Copyright © 1993 by American Physiological Society

ARTICLES

Lactate turnover at rest and during submaximal exercise in patients with heart failure

S. D. Katz, B. Bleiberg, J. Wexler, K. Bhargava, J. J. Steinberg and T. H. LeJemtel
Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461.

Systemic and lower limb skeletal muscle lactate metabolism was studied in 10 men with congestive heart failure by use of a primed continuous intravenous infusion of L-(+)-[U-14C]lactate. Arterial and deep femoral venous blood samples were obtained at rest and during 30 min of submaximal exercise. Systemic lactate metabolic turnover rate (Rd) was determined using Steele's isotopic steady-state equation (Rd = isotopic infusion rate/arterial specific activity). Plasma lactate concentrations in the artery and deep femoral vein did not change significantly from resting values during exercise (1.11 +/- 0.13 vs. 1.26 +/- 0.12 and 1.27 +/- 0.12 vs. 1.30 +/- 0.12 mM, respectively), whereas Rd increased from 22.5 +/- 1.8 to 41.6 +/- 4.8 mumol.kg-1.min-1 (P < 0.005). Rd did not significantly correlate with arterial lactate concentration during rest or exercise. Because of simultaneous uptake and release of lactate in skeletal muscle, arterial and deep femoral venous lactate concentrations are not closely related to either systemic or lower limb skeletal muscle lactate metabolism in patients with congestive heart failure.


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