Journal of Applied Physiology http://www.adinstruments.com/labchart/faseb
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 75: 1968-1973, 1993;
8750-7587/93 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Zhuang, J.
Right arrow Articles by Moore, L. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zhuang, J.
Right arrow Articles by Moore, L. G.

Journal of Applied Physiology, Vol 75, Issue 5 1968-1973, Copyright © 1993 by American Physiological Society

ARTICLES

Autonomic regulation of heart rate response to exercise in Tibetan and Han residents of Lhasa (3,658 m)

J. Zhuang, T. Droma, J. R. Sutton, R. E. McCullough, R. G. McCullough, B. M. Groves, G. Rapmund, C. Janes, S. Sun and L. G. Moore
Tibet Institute of Medical Sciences, Lhasa, China.

To test the hypothesis that native high-altitude residents have less beta-sympathetic and more parasympathetic tone than newcomers, we compared the effects of beta-sympathetic and parasympathetic blockade in 10 Tibetan and 9 Han acclimatized male residents of Lhasa, Tibet Autonomous Region, China (elevation 3,658 m). Each subject was studied during cycle ergometer exercise at 70, 132, and 191 W after placebo (normal saline), beta-sympathetic (propranolol, 0.2 mg/kg iv), or parasympathetic (atropine, 0.04 mg/kg iv) blockade in random order on different days. At rest, the fall in resting heart rate with propranolol and the rise with atropine were equal in Tibetan and Han subjects. During exercise, the fall in heart rate with propranolol relative to placebo values was greater in the Han than in the Tibetan group, whereas the rise in heart rate with atropine was greater in the Tibetans. Propranolol or atropine administration did not change minute ventilation per unit O2 consumption in either group. At the highest level of exercise on the placebo day, the Tibetans achieved a higher work load and level of O2 consumption than the Han subjects. Propranolol or atropine reduced O2 consumption and work load similarly in the two groups at the highest exercise level. The results supported our hypothesis that native Tibetan residents of high altitude exhibit more para-sympathetic and less beta-sympathetic tone during exercise. Neither relatively greater parasympathetic nor less sympathetic activation appeared implicated in the greater exercise capacity of Tibetans compared with that of acclimatized newcomer residents of high altitude.


This article has been cited by other articles:


Home page
 J. Physiol.Home page
C. Marconi, M. Marzorati, B. Grassi, B. Basnyat, A. Colombini, B. Kayser, and P. Cerretelli
Second generation Tibetan lowlanders acclimatize to high altitude more quickly than Caucasians
J. Physiol., April 15, 2004; 556(2): 661 - 671.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
C.V. Rohlicek, T. Matsuoka, and C. Saiki
Cardiovascular response to acute hypoxemia in adult rats hypoxemic neonatally
Cardiovasc Res, January 1, 2002; 53(1): 263 - 270.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
R. Boushel, J.-A. L. Calbet, G. Radegran, H. Sondergaard, P. D. Wagner, and B. Saltin
Parasympathetic Neural Activity Accounts for the Lowering of Exercise Heart Rate at High Altitude
Circulation, October 9, 2001; 104(15): 1785 - 1791.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online