Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 75: 1938-1945, 1993;
8750-7587/93 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Foster, W. M.
Right arrow Articles by Groth, M. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Foster, W. M.
Right arrow Articles by Groth, M. L.

Journal of Applied Physiology, Vol 75, Issue 5 1938-1945, Copyright © 1993 by American Physiological Society

ARTICLES

Exposure to ozone alters regional function and particle dosimetry in the human lung

W. M. Foster, J. A. Silver and M. L. Groth
Department of Environmental Health Sciences, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland 21205.

Effects of experimental exposure to O3 (0.33 ppm) or filtered air on regional lung function were assessed in nine healthy male subjects. Immediately after 2-h chamber exposures, regional ventilation and particle dosimetry were measured by gamma camera imaging. The vertical distributions of a radiolabeled gas (133Xe) and aerosol (3.5-microns-diam insoluble 99mTc-tagged Fe2O3 particles) were quantitated for upper, middle, and lower lung regions; distribution data were corrected for regional differences in lung volume and tissue attenuation. Indexes of mechanical function, inspiratory capacity, and mid-maximal expiratory flow rates were significantly reduced after O3, but functional residual capacity remained unchanged. Exposure to O3 significantly enhanced the fraction of respired aerosol retained by the lung and altered the distribution pattern of deposited aerosol by increasing particle deposition to the middle lung region (P < 0.05). Aerosol penetration indexes, i.e., ratio of particle deposition in central lung regions to that in peripheral lung regions, and particle retention 24 h postinhalation (an index of aerosol deposition within alveoli and slowly clearing bronchioles) indicated that particle filtration efficiency had increased for tracheobronchial and parenchymal lung regions. For seven of the nine subjects, regional ventilation after O3 was reduced by 14% to the lung base and enhanced by 8 and 6% to the upper and middle lung regions, respectively; these changes were significant (P < 0.02) compared with ventilation after filtered air.(ABSTRACT TRUNCATED AT 250 WORDS)


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
W. M. Foster, R. H. Brown, K. Macri, and C. S. Mitchell
Bronchial reactivity of healthy subjects: 18-20 h postexposure to ozone
J Appl Physiol, November 1, 2000; 89(5): 1804 - 1810.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
W. M. Foster and A. N. Freed
Regional clearance of solute from peripheral airway epithelia: recovery after sublobar exposure to ozone
J Appl Physiol, February 1, 1999; 86(2): 641 - 646.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
W. M. Foster, P. T. Stetkiewicz, and A. N. Freed
Retention of soluble 99mTc-DTPA in the human lung: 24-h postdeposition
J Appl Physiol, April 1, 1997; 82(4): 1378 - 1378.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online