Journal of Applied Physiology, Vol 75, Issue 4 1691-1695, Copyright © 1993 by American Physiological Society

ARTICLES

Effect of 8 wk of bicycle training on the immune system of patients with rheumatoid arthritis

B. Baslund, K. Lyngberg, V. Andersen, J. Halkjaer Kristensen, M. Hansen, M. Klokker and B. K. Pedersen
Department of Medicine TTA, Rigshospitalet, Copenhagen, Denmark.

The effect of 8 wk of progressive bicycle training on the immune system was evaluated in a controlled study on 18 patients with rheumatoid arthritis and moderate disease activity. Maximal O2 uptake increased significantly, whereas heart rate at stage 2 and rate of perceived exertion decreased significantly, in the training group compared with the controls. Resting levels of a number of immune parameters were measured before and after 4 and 8 wk of training. Training did not induce changes in blood mononuclear cell subpopulations, proliferative response, or natural killer cell activity. Furthermore the plasma concentrations of interleukin-1 alpha, interleukin-1 beta, and interleukin-6 did not change in response to training. It is concluded that 8 wk of bicycle training does not influence the immune system of patients with rheumatoid arthritis.

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