Journal of Applied Physiology, Vol 75, Issue 3 1272-1277, Copyright © 1993 by American Physiological Society

ARTICLES

Effect of concentric exercise on serum muscle and collagen markers

P. Virtanen, J. T. Viitasalo, J. Vuori, K. Vaananen and T. E. Takala
Department of Sports Medicine, University of Oulu, Finland.

The effect of an acute bout of high-intensity concentric exercise on serum muscle and collagen marker proteins was studied in nine male students. The muscle-derived serum carbonic anhydrase III, myoglobin, and creatine kinase all increased as a result of the exercise. Serum type I procollagen carboxyterminal propeptide decreased at first but started to increase 2 days after the exercise. Serum galactosylhydroxylysyl glucosyltransferase was elevated immediately after the exercise. No significant changes were seen in the concentrations of serum amino-terminal propeptide of type III procollagen or 4-hydroxyproline. It seems that a single bout of heavy concentric exercise causes protein leakage from muscles and probably from the collagen-synthesizing cells of the connective tissue, which may be accompanied by an initial decrease and a subsequent increase in type I collagen production. The activation of type I collagen production seems to depend on the strain and damage of the musculoskeletal system.

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