Journal of Applied Physiology AJP: Gastrointestinal and Liver Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 75: 1216-1221, 1993;
8750-7587/93 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Schmidt, J. A.
Right arrow Articles by Intaglietta, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Schmidt, J. A.
Right arrow Articles by Intaglietta, M.

Journal of Applied Physiology, Vol 75, Issue 3 1216-1221, Copyright © 1993 by American Physiological Society

ARTICLES

Neurogenic modulation of periodic hemodynamics in rabbit skeletal muscle

J. A. Schmidt, P. Borgstrom and M. Intaglietta
Department of Applied Mechanics and Engineering Sciences-Bioengineering, University of California, San Diego, La Jolla 92093-0412.

We characterized the effect of various forms of neural blockade and vasopressin infusion on regular slow-wave flux oscillation (RSWFO). RSWFO, measured with laser-Doppler flowmetry (LDF), was induced by local reduction of arterial pressure in the gastrocnemius muscle of 30 New Zealand White rabbits. At normal median femoral arterial mean pressure, LDF only showed irregular variations. With an intact innervation, RSWFO was maximal at a median femoral mean pressure of 30 mmHg (range 25-53), the median frequency was 1.7 cycles/min (range 1.0-3.0), and the maximum amplitude was 50% (range 19-119). Application of lidocaine to the sciatic nerve, or cutting of this nerve, when arterial pressure was reduced, resulted in disappearance of slow waves in all cases. Intravenous application of guanethidine resulted in a significant reduction of the flux oscillation amplitude from 47 to 10% (P < 0.001). In an additional nine animals with sciatic denervation and local blood pressure reduction, RSWFO could be induced by intravenous vasopressin infusion. These results offer a new pathophysiological concept of periodic hemodynamics as a locally controlled and, with intact innervation, a neurally modulated mechanism for blood flow redistribution in cases of reduced blood pressure and flow.


This article has been cited by other articles:


Home page
 Mol. Interv.Home page
H. Nilsson and C. Aalkjaer
Vasomotion: Mechanisms and Physiological Importance
Mol. Interv., March 1, 2003; 3(2): 79 - 89.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online