| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Journal of Applied Physiology, Vol 75, Issue 3 1081-1087, Copyright © 1993 by American Physiological Society
ARTICLES |
M. B. Reid, F. A. Khawli and M. R. Moody
Department of Medicine, Baylor College of Medicine, Houston, Texas 77030.
This study tested the hypothesis that reactive oxygen intermediates present in unfatigued skeletal muscle act to enhance contractile function. Fiber bundles from rat diaphragm were incubated with exogenous catalase (an antioxidant enzyme that dehydrates hydrogen peroxide to molecular oxygen and water) to decrease the tissue concentration of reactive oxygen intermediates. Catalase (10(3) U/ml) significantly decreased twitch characteristics (time to peak tension, half-relaxation time, peak force, and twitch-to-tetanus force ratio), thereby shifting the force-frequency relationship to the right. Catalase effects were dose dependent. Concentrations of 1 to 10(5) U/ml progressively depressed submaximal (30-Hz) tetanic stress, whereas concentrations > 10(5) U/ml were toxic, inhibiting maximal (200-Hz) tetanic stress (P < 0.0001). Exogenous hydrogen peroxide (10(-4) to 10(-2)M) increased peak twitch stress (P < 0.03) and lengthened both time to peak tension (P < 0.02) and half-relaxation time (P < 0.02). Selective removal of superoxide anion radicals with the use of superoxide dismutase produced dose-dependent contractile inhibition similar to that produced by catalase. We conclude that the reactive oxygen intermediates present in unfatigued skeletal muscle have a positive effect on excitation-contraction coupling and are obligatory for optimal contractile function.
This article has been cited by other articles:
|
|
 |
|
  A. R. Tupling, C. Vigna, R. J. Ford, S. C. Tsuchiya, D. A. Graham, S. G. Denniss, and J. W. E. Rush Effects of buthionine sulfoximine treatment on diaphragm contractility and SR Ca2+ pump function in rats J Appl Physiol, December 1, 2007; 103(6): 1921 - 1928. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Lecarpentier Physiological role of free radicals in skeletal muscles J Appl Physiol, December 1, 2007; 103(6): 1917 - 1918. [Full Text] [PDF]
|
|
|
|
 |
|
 N. A. Fugere, D. A. Ferrington, and L. V. Thompson Protein nitration with aging in the rat semimembranosus and soleus muscles. J. Gerontol. A Biol. Sci. Med. Sci., August 1, 2006; 61(8): 806 - 812. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Gong, S. Arbogast, Z. Guo, J. Mathenia, W. Su, and M. B. Reid Calcium-independent phospholipase A2 modulates cytosolic oxidant activity and contractile function in murine skeletal muscle cells J Appl Physiol, February 1, 2006; 100(2): 399 - 405. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Kanski, S. J. Hong, and C. Schoneich Proteomic Analysis of Protein Nitration in Aging Skeletal Muscle and Identification of Nitrotyrosine-containing Sequences in Vivo by Nanoelectrospray Ionization Tandem Mass Spectrometry J. Biol. Chem., June 24, 2005; 280(25): 24261 - 24266. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. P. Wright, P. F. Klawitter, D. F. Iscru, A. J. Merola, and T. L. Clanton Superoxide scavengers augment contractile but not energetic responses to hypoxia in rat diaphragm J Appl Physiol, May 1, 2005; 98(5): 1753 - 1760. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Kanski, A. Behring, J. Pelling, and C. Schoneich Proteomic identification of 3-nitrotyrosine-containing rat cardiac proteins: effects of biological aging Am J Physiol Heart Circ Physiol, January 1, 2005; 288(1): H371 - H381. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Arbogast and M. B. Reid Oxidant activity in skeletal muscle fibers is influenced by temperature, CO2 level, and muscle-derived nitric oxide Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2004; 287(4): R698 - R705. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Medved, M. J. Brown, A. R. Bjorksten, and M. J. McKenna Effects of intravenous N-acetylcysteine infusion on time to fatigue and potassium regulation during prolonged cycling exercise J Appl Physiol, January 1, 2004; 96(1): 211 - 217. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. P. Eu, J. M. Hare, D. T. Hess, M. Skaf, J. Sun, I. Cardenas-Navina, Q.-A. Sun, M. Dewhirst, G. Meissner, and J. S. Stamler Concerted regulation of skeletal muscle contractility by oxygen tension and endogenous nitric oxide PNAS, December 9, 2003; 100(25): 15229 - 15234. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Xia, J. A. Webb, L. L. M. Gnall, K. Cutler, and J. J. Abramson Skeletal muscle sarcoplasmic reticulum contains a NADH-dependent oxidase that generates superoxide Am J Physiol Cell Physiol, July 1, 2003; 285(1): C215 - C221. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Medved, M. J. Brown, A. R. Bjorksten, J. A. Leppik, S. Sostaric, and M. J. McKenna N-acetylcysteine infusion alters blood redox status but not time to fatigue during intense exercise in humans J Appl Physiol, April 1, 2003; 94(4): 1572 - 1582. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Oba, C. Kurono, R. Nakajima, T. Takaishi, K. Ishida, G. A. Fuller, W. Klomkleaw, and M. Yamaguchi H2O2 activates ryanodine receptor but has little effect on recovery of releasable Ca2+ content after fatigue J Appl Physiol, December 1, 2002; 93(6): 1999 - 2008. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. B. REID and W. J. DURHAM Generation of Reactive Oxygen and Nitrogen Species in Contracting Skeletal Muscle: Potential Impact on Aging Ann. N.Y. Acad. Sci., April 1, 2002; 959(1): 108 - 116. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. JAVESGHANI, S. A. MAGDER, E. BARREIRO, M. T. QUINN, and S. N. A. HUSSAIN Molecular Characterization of a Superoxide-Generating NAD(P)H Oxidase in the Ventilatory Muscles Am. J. Respir. Crit. Care Med., February 1, 2002; 165(3): 412 - 418. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. M. A. Heunks, H. A. Machiels, R. de Abreu, X. Ping Zhu, H. F. M. van der Heijden, and P. N. R. Dekhuijzen Free radicals in hypoxic rat diaphragm contractility: no role for xanthine oxidase Am J Physiol Lung Cell Mol Physiol, December 1, 2001; 281(6): L1402 - L1412. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Coombes, S. K. Powers, B. Rowell, K. L. Hamilton, S. L. Dodd, R. A. Shanely, C. K. Sen, and L. Packer Effects of vitamin E and {alpha}-lipoic acid on skeletal muscle contractile properties J Appl Physiol, April 1, 2001; 90(4): 1424 - 1430. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. R. Plant, P. Gregorevic, D. A. Williams, and G. S. Lynch Redox modulation of maximum force production of fast-and slow-twitch skeletal muscles of rats and mice J Appl Physiol, March 1, 2001; 90(3): 832 - 838. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. B. Reid Plasticity in Skeletal, Cardiac, and Smooth Muscle: Invited Review: Redox modulation of skeletal muscle contraction: what we know and what we don't J Appl Physiol, February 1, 2001; 90(2): 724 - 731. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. Stamler and G. Meissner Physiology of Nitric Oxide in Skeletal Muscle Physiol Rev, January 1, 2001; 81(1): 209 - 237. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Oba, T. Ishikawa, T. Murayama, Y. Ogawa, and M. Yamaguchi H2O2 and ethanol act synergistically to gate ryanodine receptor/calcium-release channel Am J Physiol Cell Physiol, November 1, 2000; 279(5): C1366 - C1374. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. P. Moore, J.-Z. Zhang, and S. L. Hamilton A Role for Cysteine 3635 of RYR1 in Redox Modulation and Calmodulin Binding J. Biol. Chem., December 24, 1999; 274(52): 36831 - 36834. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. L. Clanton, L. Zuo, and P. Klawitter Oxidants and Skeletal Muscle Function: Physiologic and Pathophysiologic Implications Experimental Biology and Medicine, December 1, 1999; 222(3): 253 - 262. [Abstract] [Full Text]
|
|
|
|
|
|
T. M. Best, R. Fiebig, D. T. Corr, S. Brickson, and L. Ji Free radical activity, antioxidant enzyme, and glutathione changes with muscle stretch injury in rabbits J Appl Physiol, July 1, 1999; 87(1): 74 - 82. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Skeletal Muscle Dysfunction in Chronic Obstructive Pulmonary Disease . A Statement of the American Thoracic Society and European Respiratory Society Am. J. Respir. Crit. Care Med., April 1, 1999; 159(4): S2 - 40. [Full Text] [PDF]
|
|
|
|
|
|
H. F. M. van der Heijden, L. M. A. Heunks, H. Folgering, C. L. A. van Herwaarden, and P. N. R. Dekhuijzen beta 2-Adrenoceptor agonists reduce the decline of rat diaphragm twitch force during severe hypoxia Am J Physiol Lung Cell Mol Physiol, March 1, 1999; 276(3): L474 - L480. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. I. Kourie Interaction of reactive oxygen species with ion transport mechanisms Am J Physiol Cell Physiol, July 1, 1998; 275(1): C1 - C24. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-p. Li, R. J. Schwartz, I. D. Waddell, B. R. Holloway, and M. B. Reid Skeletal muscle myocytes undergo protein loss and reactive oxygen-mediated NF-{kappa}B activation in response to tumor necrosis factor {alpha} FASEB J, July 1, 1998; 12(10): 871 - 880. [Abstract] [Full Text]
|
|
|
|
|
|
T. Oba, T. Ishikawa, and M. Yamaguchi Sulfhydryls associated with H2O2-induced channel activation are on luminal side of ryanodine receptors Am J Physiol Cell Physiol, April 1, 1998; 274(4): C914 - C921. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Lawler, Z. Hu, and W. S. Barnes Effect of reactive oxygen species on K+ contractures in the rat diaphragm J Appl Physiol, March 1, 1998; 84(3): 948 - 953. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Aghdasi, M. B. Reid, and S. L. Hamilton Nitric Oxide Protects the Skeletal Muscle Ca2+ Release Channel from Oxidation Induced Activation J. Biol. Chem., October 10, 1997; 272(41): 25462 - 25467. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Wu, B. Aghdasi, S. J. Dou, J. Z. Zhang, S. Q. Liu, and S. L. Hamilton Functional Interactions between Cytoplasmic Domains of the Skeletal Muscle Ca2+ Release Channel J. Biol. Chem., October 3, 1997; 272(40): 25051 - 25061. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Aghdasi, J.-Z. Zhang, Y. Wu, M. B. Reid, and S. L. Hamilton Multiple Classes of Sulfhydryls Modulate the Skeletal Muscle Ca2+ Release Channel J. Biol. Chem., February 7, 1997; 272(6): 3739 - 3748. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Xia, T. Stangler, and J. J. Abramson Skeletal Muscle Ryanodine Receptor Is a Redox Sensor with a Well Defined Redox Potential That Is Sensitive to Channel Modulators J. Biol. Chem., November 17, 2000; 275(47): 36556 - 36561. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Sun, L. Xu, J. P. Eu, J. S. Stamler, and G. Meissner Classes of Thiols That Influence the Activity of the Skeletal Muscle Calcium Release Channel J. Biol. Chem., May 4, 2001; 276(19): 15625 - 15630. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Oba, T. Murayama, and Y. Ogawa Redox states of type 1 ryanodine receptor alter Ca2+ release channel response to modulators Am J Physiol Cell Physiol, April 1, 2002; 282(4): C684 - C692. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
