Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 74: 2795-2800, 1993;
8750-7587/93 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Behm, R.
Right arrow Articles by Rettig, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Behm, R.
Right arrow Articles by Rettig, R.

Journal of Applied Physiology, Vol 74, Issue 6 2795-2800, Copyright © 1993 by American Physiological Society

ARTICLES

Cardiovascular and renal effects of hypoxia in conscious carotid body-denervated rats

R. Behm, H. Mewes, W. H. DeMuinck Keizer, T. Unger and R. Rettig
Department of Pharmacology, University of Heidelberg, Germany.

The contribution of peripheral arterial chemoreceptors to cardiovascular and renal responses to acute hypocapnic hypoxia is currently not well understood. We compared the effects of normobaric hypoxia on mean arterial blood pressure (MABP), heart rate, glomerular filtration rate (GFR), renal blood flow (RBF), and renal volume and electrolyte excretion in conscious unilaterally nephrectomized carotid body-denervated (n = 10) and sham-operated (n = 10) control rats. Thirty minutes of normobaric hypoxia (12.5% O2) resulted in significant reductions in arterial PO2 and PCO2 as well as decreases in MABP, GFR, RBF, and renal sodium, potassium, and water excretion. These effects occurred more rapidly and/or were significantly more pronounced in carotid body-denervated than in sham-operated rats. These data indicate that moderate acute hypocapnic hypoxia has profound effects on systemic and renal hemodynamics as well as on renal excretory function in conscious rats. We conclude that stimulation of the peripheral arterial chemoreceptors can partially offset the hypoxia-induced decreases in MABP, RBF, GFR, urine flow, and urinary sodium and potassium excretion, thereby helping to maintain cardiovascular as well as fluid and electrolyte homeostasis.


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
R. W. Bavis and G. S. Mitchell
Plasticity in Respiratory Motor Control: Selected Contribution: Intermittent hypoxia induces phrenic long-term facilitation in carotid-denervated rats
J Appl Physiol, January 1, 2003; 94(1): 399 - 409.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
M. McGuire and A. Bradford
Chronic intermittent hypercapnic hypoxia increases pulmonary arterial pressure and haematocrit in rats
Eur. Respir. J., August 1, 2001; 18(2): 279 - 285.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. Zaccaria, S. Rocco, D. Noventa, M. Varnier, and G. Opocher
Sodium Regulating Hormones at High Altitude: Basal and Post-Exercise Levels
J. Clin. Endocrinol. Metab., February 1, 1998; 83(2): 570 - 574.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online