Journal of Applied Physiology Millar Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 74: 2771-2781, 1993;
8750-7587/93 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lambert, R. K.
Right arrow Articles by Pare, P. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lambert, R. K.
Right arrow Articles by Pare, P. D.

Journal of Applied Physiology, Vol 74, Issue 6 2771-2781, Copyright © 1993 by American Physiological Society

ARTICLES

Functional significance of increased airway smooth muscle in asthma and COPD

R. K. Lambert, B. R. Wiggs, K. Kuwano, J. C. Hogg and P. D. Pare
Department of Physics and Biophysics, Massey University, Palmerston North, New Zealand.

Using a computational model, we investigated the effect of the morphologically determined increased airway smooth muscle mass, adventitial mass, and submucosal mass observed in patients with asthma and chronic obstructive pulmonary disease (COPD) on the increase in airway resistance in response to a bronchoconstricting stimulus. The computational model of Wiggs et al. (J. Appl. Physiol. 69: 849-860, 1990) was modified in such a way that smooth muscle shortening was limited by the maximal stress that the muscle could develop at the constricted length. Increased adventitial thickness was found to increase constriction by reducing parenchymal interdependence. Increased submucosal thickness led to greater luminal occlusion for any degree of smooth muscle shortening. Increased muscle thickness allowed greater smooth muscle shortening against the elastic loads provided by parenchymal interdependence and airway wall stiffness. We found that for constant airway mechanics, as reflected by the passive area-pressure curves of the airways, the increased muscle mass is likely to be the most important abnormality responsible for the increased resistance observed in response to bronchoconstricting stimuli in asthma and COPD. For a given maximal muscle stress, greater muscle thickness allows the development of greater tension and thus more constriction of the lumen.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
I. Labonte, M. Hassan, P.-A. Risse, K. Tsuchiya, M. Laviolette, A.-M. Lauzon, and J. G. Martin
The effects of repeated allergen challenge on airway smooth muscle structural and molecular remodeling in a rat model of allergic asthma
Am J Physiol Lung Cell Mol Physiol, October 1, 2009; 297(4): L698 - L705.
[Abstract] [Full Text] [PDF]

Home page
 Ther Adv Respir DisHome page
M. Baroffio, G. Barisione, E. Crimi, and V. Brusasco
Noninflammatory mechanisms of airway hyper-responsiveness in bronchial asthma: an overview
Therapeutic Advances in Respiratory Disease, August 1, 2009; 3(4): 163 - 174.
[Abstract] [PDF]

Home page
 DMMHome page
F. A. DiGiovanni, R. Ellis, J. Wattie, J. A. Hirota, D. S. Southam, and M. D. Inman
Concurrent dual allergen exposure and its effects on airway hyperresponsiveness, inflammation and remodeling in mice
Dis. Model. Mech., May 1, 2009; 2(5-6): 275 - 282.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. Leguillette, M. Laviolette, C. Bergeron, N. Zitouni, P. Kogut, J. Solway, L. Kachmar, Q. Hamid, and A.-M. Lauzon
Myosin, Transgelin, and Myosin Light Chain Kinase: Expression and Function in Asthma
Am. J. Respir. Crit. Care Med., February 1, 2009; 179(3): 194 - 204.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
M. Tamaoka, M. Hassan, T. McGovern, D. Ramos-Barbon, T. Jo, Y. Yoshizawa, B. Tolloczko, Q. Hamid, and J. G. Martin
The epidermal growth factor receptor mediates allergic airway remodelling in the rat
Eur. Respir. J., November 1, 2008; 32(5): 1213 - 1223.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
S. Zuyderduyn, M. B. Sukkar, A. Fust, S. Dhaliwal, and J. K. Burgess
Treating asthma means treating airway smooth muscle cells
Eur. Respir. J., August 1, 2008; 32(2): 265 - 274.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
H. Meurs, R. Gosens, and J. Zaagsma
Airway hyperresponsiveness in asthma: lessons from in vitro model systems and animal models
Eur. Respir. J., August 1, 2008; 32(2): 487 - 502.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
V. Kim, T. J. Rogers, and G. J. Criner
New Concepts in the Pathobiology of Chronic Obstructive Pulmonary Disease
Proceedings of the ATS, May 1, 2008; 5(4): 478 - 485.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
P. Joubert, S. Lajoie-Kadoch, M. Welman, S. Dragon, S. Letuvee, B. Tolloczko, A. J. Halayko, A. S. Gounni, K. Maghni, and Q. Hamid
Expression and Regulation of CCR1 by Airway Smooth Muscle Cells in Asthma
J. Immunol., January 15, 2008; 180(2): 1268 - 1275.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
R. B. Penn and J. L. Benovic
Regulation of Heterotrimeric G Protein Signaling in Airway Smooth Muscle
Proceedings of the ATS, January 1, 2008; 5(1): 47 - 57.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
J. K. Bentley and M. B. Hershenson
Airway Smooth Muscle Growth in Asthma: Proliferation, Hypertrophy, and Migration
Proceedings of the ATS, January 1, 2008; 5(1): 89 - 96.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
T. Trian, G. Benard, H. Begueret, R. Rossignol, P.-O. Girodet, D. Ghosh, O. Ousova, J.-M. Vernejoux, R. Marthan, J.-M. Tunon-de-Lara, et al.
Bronchial smooth muscle remodeling involves calcium-dependent enhanced mitochondrial biogenesis in asthma
J. Exp. Med., December 24, 2007; 204(13): 3173 - 3181.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
S. Siddiqui, F. Hollins, S. Saha, and C. E. Brightling
Inflammatory cell microlocalisation and airway dysfunction: cause and effect?
Eur. Respir. J., December 1, 2007; 30(6): 1043 - 1056.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
L-P. Boulet and P. J. Sterk
Airway remodelling: the future
Eur. Respir. J., November 1, 2007; 30(5): 831 - 834.
[Full Text] [PDF]

Home page
 ThoraxHome page
H. Matsumoto, L. M Moir, B. G G Oliver, J. K Burgess, M. Roth, J. L Black, and B. E McParland
Comparison of gel contraction mediated by airway smooth muscle cells from patients with and without asthma
Thorax, October 1, 2007; 62(10): 848 - 854.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
M. N. Oliver, B. Fabry, A. Marinkovic, S. M. Mijailovich, J. P. Butler, and J. J. Fredberg
Airway Hyperresponsiveness, Remodeling, and Smooth Muscle Mass: Right Answer, Wrong Reason?
Am. J. Respir. Cell Mol. Biol., September 1, 2007; 37(3): 264 - 272.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
L. Cohen, X. E, J. Tarsi, T. Ramkumar, T. K. Horiuchi, R. Cochran, S. DeMartino, K. B. Schechtman, I. Hussain, M. J. Holtzman, et al.
Epithelial Cell Proliferation Contributes to Airway Remodeling in Severe Asthma
Am. J. Respir. Crit. Care Med., July 15, 2007; 176(2): 138 - 145.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
N. J. Brown, C. M. Salome, N. Berend, C. W. Thorpe, and G. G. King
Airway Distensibility in Adults with Asthma and Healthy Adults, Measured by Forced Oscillation Technique
Am. J. Respir. Crit. Care Med., July 15, 2007; 176(2): 129 - 137.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
A. L. James and S. Wenzel
Clinical relevance of airway remodelling in airway diseases
Eur. Respir. J., July 1, 2007; 30(1): 134 - 155.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
D. Schaafsma, K. D. McNeill, G. L. Stelmack, R. Gosens, H. A. Baarsma, B. G. J. Dekkers, E. Frohwerk, J.-M. Penninks, P. Sharma, K. M. Ens, et al.
Insulin increases the expression of contractile phenotypic markers in airway smooth muscle
Am J Physiol Cell Physiol, July 1, 2007; 293(1): C429 - C439.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
S. S. An, T. R. Bai, J. H. T. Bates, J. L. Black, R. H. Brown, V. Brusasco, P. Chitano, L. Deng, M. Dowell, D. H. Eidelman, et al.
Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma
Eur. Respir. J., May 1, 2007; 29(5): 834 - 860.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
C. M. Lloyd and D. S. Robinson
Allergen-induced airway remodelling
Eur. Respir. J., May 1, 2007; 29(5): 1020 - 1032.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
H. H. Kariyawasam, M. Aizen, J. Barkans, D. S. Robinson, and A. B. Kay
Remodeling and Airway Hyperresponsiveness but Not Cellular Inflammation Persist after Allergen Challenge in Asthma
Am. J. Respir. Crit. Care Med., May 1, 2007; 175(9): 896 - 904.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
E. D. Fixman, A. Stewart, and J. G. Martin
Basic mechanisms of development of airway structural changes in asthma
Eur. Respir. J., February 1, 2007; 29(2): 379 - 389.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
L. Pini, Q. Hamid, J. Shannon, L. Lemelin, R. Olivenstein, P. Ernst, C. Lemiere, J. G. Martin, and M. S. Ludwig
Differences in proteoglycan deposition in the airways of moderate and severe asthmatics
Eur. Respir. J., January 1, 2007; 29(1): 71 - 77.
[Abstract] [Full Text] [PDF]

Home page
 ERRHome page
V. Brusasco
Reducing cholinergic constriction: the major reversible mechanism in COPD
Eur. Respir. Rev., December 1, 2006; 15(99): 32 - 36.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. A. Affonce and K. R. Lutchen
New perspectives on the mechanical basis for airway hyperreactivity and airway hypersensitivity in asthma
J Appl Physiol, December 1, 2006; 101(6): 1710 - 1719.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
M. M. Kelly, J. Chakir, D. Vethanayagam, L.-P. Boulet, M. Laviolette, J. Gauldie, and P. M. O'Byrne
Montelukast treatment attenuates the increase in myofibroblasts following low-dose allergen challenge.
Chest, September 1, 2006; 130(3): 741 - 753.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
B. J. Canning
Reflex regulation of airway smooth muscle tone
J Appl Physiol, September 1, 2006; 101(3): 971 - 985.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
B. Chen, G. Liu, F. Shardonofsky, M. Dowell, O. Lakser, R. W. Mitchell, J. J. Fredberg, L. H. Pinto, and J. Solway
Tidal breathing pattern differentially antagonizes bronchoconstriction in C57BL/6J vs. A/J mice
J Appl Physiol, July 1, 2006; 101(1): 249 - 255.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
S. S. An, B. Fabry, X. Trepat, N. Wang, and J. J. Fredberg
Do Biophysical Properties of the Airway Smooth Muscle in Culture Predict Airway Hyperresponsiveness?
Am. J. Respir. Cell Mol. Biol., July 1, 2006; 35(1): 55 - 64.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
B. Fouty, T. Moss, V. Solodushko, and M. Kraft
Dexamethasone can stimulate G1-S phase transition in human airway fibroblasts in asthma
Eur. Respir. J., June 1, 2006; 27(6): 1160 - 1167.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
S-W Park, J-S Park, Y-M Lee, J-H Lee, A-S Jang, D-J Kim, Y Hwangbo, S-T Uh, Y-H Kim, and C-S Park
Differences in radiological/HRCT findings in eosinophilic bronchitis and asthma: implication for bronchial responsiveness
Thorax, January 1, 2006; 61(1): 41 - 47.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
B. E. McParland, R. R. Tait, P. D. Pare, and C. Y. Seow
The Role of Airway Smooth Muscle during an Attack of Asthma Simulated In Vitro
Am. J. Respir. Cell Mol. Biol., November 1, 2005; 33(5): 500 - 504.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
P. Joubert, S. Lajoie-Kadoch, I. Labonte, A. S. Gounni, K. Maghni, V. Wellemans, J. Chakir, M. Laviolette, Q. Hamid, and B. Lamkhioued
CCR3 Expression and Function in Asthmatic Airway Smooth Muscle Cells
J. Immunol., August 15, 2005; 175(4): 2702 - 2708.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
M. M. Kelly, R. Leigh, P. Bonniaud, R. Ellis, J. Wattie, M. J. Smith, G. Martin, M. Panju, M. D. Inman, and J. Gauldie
Epithelial Expression of Profibrotic Mediators in a Model of Allergen-Induced Airway Remodeling
Am. J. Respir. Cell Mol. Biol., February 1, 2005; 32(2): 99 - 107.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. Leigh, D. S. Southam, R. Ellis, J. N. Wattie, R. Sehmi, Y. Wan, and M. D. Inman
T-cell-mediated inflammation does not contribute to the maintenance of airway dysfunction in mice
J Appl Physiol, December 1, 2004; 97(6): 2258 - 2265.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. Leigh, R. Ellis, J. Wattie, D. D. Donaldson, and M. D. Inman
Is Interleukin-13 Critical in Maintaining Airway Hyperresposiveness in Allergen-challenged Mice?
Am. J. Respir. Crit. Care Med., October 15, 2004; 170(8): 851 - 856.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
A.G. Stewart
Emigration and immigration of mesenchymal cells: a multicultural airway wall
Eur. Respir. J., October 1, 2004; 24(4): 515 - 517.
[Full Text] [PDF]

Home page
 ThoraxHome page
C E Brightling and I D Pavord
Location, location, location: microlocalisation of inflammatory cells and airway dysfunction
Thorax, September 1, 2004; 59(9): 734 - 735.
[Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
B. E. McParland, P. D. Pare, P. R. A. Johnson, C. L. Armour, and J. L. Black
Airway basement membrane perimeter in human airways is not a constant; potential implications for airway remodeling in asthma
J Appl Physiol, August 1, 2004; 97(2): 556 - 563.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
P. G. Woodruff, G. M. Dolganov, R. E. Ferrando, S. Donnelly, S. R. Hays, O. D. Solberg, R. Carter, H. H. Wong, P. S. Cadbury, and J. V. Fahy
Hyperplasia of Smooth Muscle in Mild to Moderate Asthma without Changes in Cell Size or Gene Expression
Am. J. Respir. Crit. Care Med., May 1, 2004; 169(9): 1001 - 1006.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
S Baraldo, G Turato, C Badin, E Bazzan, B Beghe, R Zuin, F Calabrese, G Casoni, P Maestrelli, A Papi, et al.
Neutrophilic infiltration within the airway smooth muscle in patients with COPD
Thorax, April 1, 2004; 59(4): 308 - 312.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. Leigh, R. Ellis, J. N. Wattie, J. A. Hirota, K. I. Matthaei, P. S. Foster, P. M. O'Byrne, and M. D. Inman
Type 2 Cytokines in the Pathogenesis of Sustained Airway Dysfunction and Airway Remodeling in Mice
Am. J. Respir. Crit. Care Med., April 1, 2004; 169(7): 860 - 867.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
P. D. Pare
Airway Hyperresponsiveness in Asthma: Geometry Is Not Everything!
Am. J. Respir. Crit. Care Med., October 15, 2003; 168(8): 913 - 914.
[Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
V. Brusasco and R. Pellegrino
Invited Review: Complexity of factors modulating airway narrowing in vivo: relevance to assessment of airway hyperresponsiveness
J Appl Physiol, September 1, 2003; 95(3): 1305 - 1313.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
N J Kenyon, R W Ward, G McGrew, and J A Last
TGF-{beta}1 causes airway fibrosis and increased collagen I and III mRNA in mice
Thorax, September 1, 2003; 58(9): 772 - 777.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. J. Fernandes, R. W. Mitchell, O. Lakser, M. Dowell, A. G. Stewart, and J. Solway
Invited Review: Do inflammatory mediators influence the contribution of airway smooth muscle contraction to airway hyperresponsiveness in asthma?
J Appl Physiol, August 1, 2003; 95(2): 844 - 853.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
B. E. McParland, P. T. Macklem, and P. D. Pare
Airway wall remodeling: friend or foe?
J Appl Physiol, July 1, 2003; 95(1): 426 - 434.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A. Corsico, M. Milanese, S. Baraldo, G. L. Casoni, A. Papi, A. M. Riccio, I. Cerveri, M. Saetta, and V. Brusasco
Small airway morphology and lung function in the transition from normality to chronic airway obstruction
J Appl Physiol, July 1, 2003; 95(1): 441 - 447.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
S T Holgate, D E Davies, G Murphy, R M Powell, and J W Holloway
ADAM 33: just another asthma gene or a breakthrough in understanding the origins of bronchial hyperresponsiveness?
Thorax, June 1, 2003; 58(6): 466 - 469.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
L. Benayoun, A. Druilhe, M.-C. Dombret, M. Aubier, and M. Pretolani
Airway Structural Alterations Selectively Associated with Severe Asthma
Am. J. Respir. Crit. Care Med., May 15, 2003; 167(10): 1360 - 1368.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. C. Anafi, K. C. Beck, and T. A. Wilson
Impedance, gas mixing, and bimodal ventilation in constricted lungs
J Appl Physiol, March 1, 2003; 94(3): 1003 - 1011.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
L. Wang, B. E. McParland, and P. D. Pare
The Functional Consequences of Structural Changes in the Airways: Implications for Airway Hyperresponsiveness in Asthma
Chest, March 1, 2003; 123 (2009): 356S - 362S.
[Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
K. Maghni, M.-C. Michoud, M. Alles, A. Rubin, V. Govindaraju, C. Meloche, and J. G. Martin
Airway Smooth Muscle Cells Express Functional Neurokinin-1 Receptors and the Nerve-Derived Preprotachykinin-A Gene: Regulation by Passive Sensitization
Am. J. Respir. Cell Mol. Biol., January 1, 2003; 28(1): 103 - 110.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
J. J. Fredberg
Airway narrowing in asthma: does speed kill?
Am J Physiol Lung Cell Mol Physiol, December 1, 2002; 283(6): L1179 - L1180.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
H. C. Pandya, V. A. Snetkov, C. H. C. Twort, J. P. T. Ward, and S. J. Hirst
Oxygen regulates mitogen-stimulated proliferation of fetal human airway smooth muscle cells
Am J Physiol Lung Cell Mol Physiol, December 1, 2002; 283(6): L1220 - L1230.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
R. Leigh, R. Ellis, J. Wattie, D. S. Southam, M. de Hoogh, J. Gauldie, P. M. O'Byrne, and M. D. Inman
Dysfunction and Remodeling of the Mouse Airway Persist after Resolution of Acute Allergen-Induced Airway Inflammation
Am. J. Respir. Cell Mol. Biol., November 1, 2002; 27(5): 526 - 535.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. M. Smiley-Jewell, M. U. Tran, A. J. Weir, Z. A. Johnson, L. S. Van Winkle, and C. G. Plopper
Three-dimensional mapping of smooth muscle in the distal conducting airways of mouse, rabbit, and monkey
J Appl Physiol, October 1, 2002; 93(4): 1506 - 1514.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. K. Lambert, R. Ramchandani, X. Shen, S. J. Gunst, and R. S. Tepper
Computational model of airway narrowing: mature vs. immature rabbit
J Appl Physiol, August 1, 2002; 93(2): 611 - 619.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. C. Anafi and T. A. Wilson
Empirical model for dynamic force-length behavior of airway smooth muscle
J Appl Physiol, February 1, 2002; 92(2): 455 - 460.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. Latourelle, B. Fabry, and J. J. Fredberg
Dynamic equilibration of airway smooth muscle contraction during physiological loading
J Appl Physiol, February 1, 2002; 92(2): 771 - 779.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
K. Parameswaran, L. J. Janssen, and P. M. O'Byrne
Airway Hyperresponsiveness and Calcium Handling by Smooth Muscle : A "Deeper Look"
Chest, February 1, 2002; 121(2): 621 - 624.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
P. K. JEFFERY
Remodeling in Asthma and Chronic Obstructive Lung Disease
Am. J. Respir. Crit. Care Med., November 15, 2001; 164(10): S28 - 38.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. Milanese, E. Crimi, A. Scordamaglia, A. Riccio, R. Pellegrino, G. W. Canonica, and V. Brusasco
On the functional consequences of bronchial basement membrane thickening
J Appl Physiol, September 1, 2001; 91(3): 1035 - 1040.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. C. Anafi and T. A. Wilson
Airway stability and heterogeneity in the constricted lung
J Appl Physiol, September 1, 2001; 91(3): 1185 - 1192.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
P. D. Upton, J. Wharton, N. Davie, M. A. Ghatei, D. M. Smith, and N. W. Morrell
Differential Adrenomedullin Release and Endothelin Receptor Expression in Distinct Subpopulations of Human Airway Smooth-Muscle Cells
Am. J. Respir. Cell Mol. Biol., September 1, 2001; 25(3): 316 - 325.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. Y. Seow and J. J. Fredberg
Signal Transduction in Smooth Muscle: Historical perspective on airway smooth muscle: the saga of a frustrated cell
J Appl Physiol, August 1, 2001; 91(2): 938 - 952.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
P. R. A. JOHNSON, M. ROTH, M. TAMM, M. HUGHES, Q. GE, G. KING, J. K. BURGESS, and J. L. BLACK
Airway Smooth Muscle Cell Proliferation Is Increased in Asthma
Am. J. Respir. Crit. Care Med., August 1, 2001; 164(3): 474 - 477.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
K. R. LUTCHEN, A. JENSEN, H. ATILEH, D. W. KACZKA, E. ISRAEL, B. SUKI, and E. P. INGENITO
Airway Constriction Pattern Is a Central Component of Asthma Severity . The Role of Deep Inspirations
Am. J. Respir. Crit. Care Med., July 15, 2001; 164(2): 207 - 215.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
M. Saetta and G. Turato
Airway pathology in asthma
Eur. Respir. J., July 2, 2001; 18(34_suppl): 18S - 23s.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
U. Holzhauser and R. K. Lambert
Analysis of tracheal mechanics and applications
J Appl Physiol, July 1, 2001; 91(1): 290 - 297.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A. Jensen, H. Atileh, B. Suki, E. P. Ingenito, and K. R. Lutchen
Signal Transduction in Smooth Muscle: Selected Contribution: Airway caliber in healthy and asthmatic subjects: effects of bronchial challenge and deep inspirations
J Appl Physiol, July 1, 2001; 91(1): 506 - 515.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. K. Lambert, P. D. Pare, and M. Okazawa
Stiffness of peripheral airway folding membrane in rabbits
J Appl Physiol, June 1, 2001; 90(6): 2041 - 2047.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. Van Den BERGE, R. J. MEIJER, H. A. M. KERSTJENS, D. M. de REUS, G. H. KOETER, H. F. KAUFFMAN, and D. S. POSTMA
PC20 Adenosine 5'-Monophosphate Is More Closely Associated with Airway Inflammation in Asthma Than PC20 Methacholine
Am. J. Respir. Crit. Care Med., June 1, 2001; 163(7): 1546 - 1550.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. Okazawa, P. D. Pare, and R. K. Lambert
Compliance of peripheral airways deduced from morphometry
J Appl Physiol, December 1, 2000; 89(6): 2373 - 2381.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. Uhlig, A. Wohlsen, F. Brasch, C. Y. Seow, and P. D. Pare
Can airways close completely?
J Appl Physiol, December 1, 2000; 89(6): 2521 - 2522.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
A. Trifilieff, A. El-Hashim, and C. Bertrand
Time course of inflammatory and remodeling events in a murine model of asthma: effect of steroid treatment
Am J Physiol Lung Cell Mol Physiol, December 1, 2000; 279(6): L1120 - L1128.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. Ramchandani, X. Shen, C. L. Elmsley, W. T. Ambrosius, S. J. Gunst, and R. S. Tepper
Differences in airway structure in immature and mature rabbits
J Appl Physiol, October 1, 2000; 89(4): 1310 - 1316.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
T. R. BAI, J. COOPER, T. KOELMEYER, P. D. PARE, and T. D. WEIR
The Effect of Age and Duration of Disease on Airway Structure in Fatal Asthma
Am. J. Respir. Crit. Care Med., August 1, 2000; 162(2): 663 - 669.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
H. TIDDENS, M. SILVERMAN, and A. BUSH
The Role of Inflammation in Airway Disease . Remodeling
Am. J. Respir. Crit. Care Med., August 1, 2000; 162(2): S7 - 10.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. C. C. M.i.`t VEEN, A. J. BEEKMAN, E. H. BEL, and P. J. STERK
Recurrent Exacerbations in Severe Asthma Are Associated with Enhanced Airway Closure During Stable Episodes
Am. J. Respir. Crit. Care Med., June 1, 2000; 161(6): 1902 - 1906.
[Abstract] [Full Text]

Home page
 ChestHome page
C. Kuhn, R. J. Homer, Z. Zhu, N. Ward, and J. A. Elias
Morphometry Explains Variation in Airway Responsiveness in Transgenic Mice Overexpressing Interleukin-6 and Interleukin-11 in the Lung
Chest, May 1, 2000; 117 (2009): 260S - 262S.
[Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
C. Kuhn III, R. J. Homer, Z. Zhu, N. Ward, R. A. Flavell, G. P. Geba, and J. A. Elias
Airway Hyperresponsiveness and Airway Obstruction in Transgenic Mice . Morphologic Correlates in Mice Overexpressing Interleukin (IL)-11 and IL-6 in the Lung
Am. J. Respir. Cell Mol. Biol., March 1, 2000; 22(3): 289 - 295.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. SAETTA, G. TURATO, S. BARALDO, A. ZANIN, F. BRACCIONI, C. E. MAPP, P. MAESTRELLI, G. CAVALLESCO, A. PAPI, and L. M. FABBRI
Goblet Cell Hyperplasia and Epithelial Inflammation in Peripheral Airways of Smokers with Both Symptoms of Chronic Bronchitis and Chronic Airflow Limitation
Am. J. Respir. Crit. Care Med., March 1, 2000; 161(3): 1016 - 1021.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. J. FREDBERG
Airway Smooth Muscle in Asthma . Perturbed Equilibria of Myosin Binding
Am. J. Respir. Crit. Care Med., March 1, 2000; 161(3): S158 - 160.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
E. PALMANS, J. C. KIPS, and R. A. PAUWELS
Prolonged Allergen Exposure Induces Structural Airway Changes in Sensitized Rats
Am. J. Respir. Crit. Care Med., February 1, 2000; 161(2): 627 - 635.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. E. Zacour and J. G. Martin
Protein kinase C is involved in enhanced airway smooth muscle cell growth in hyperresponsive rats
Am J Physiol Lung Cell Mol Physiol, January 1, 2000; 278(1): L59 - L67.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
E. T. NAURECKAS, I. MAURICE NDUKWU, A. J. HALAYKO, C. MAXWELL, M. B. HERSHENSON, and J. SOLWAY
Bronchoalveolar Lavage Fluid from Asthmatic Subjects Is Mitogenic for Human Airway Smooth Muscle
Am. J. Respir. Crit. Care Med., December 1, 1999; 160(6): 2062 - 2066.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
H. A. W. M. TIDDENS, W. HOFHUIS, J. M. BOGAARD, W. C. J. HOP, H. de BRUIN, L. N. A. WILLEMS, and J. C. de JONGSTE
Compliance, Hysteresis, and Collapsibility of Human Small Airways
Am. J. Respir. Crit. Care Med., October 1, 1999; 160(4): 1110 - 1118.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. J. Orsini, V. P. Krymskaya, A. J. Eszterhas, J. L. Benovic, R. A. Panettieri Jr., and R. B. Penn
MAPK superfamily activation in human airway smooth muscle: mitogenesis requires prolonged p42/p44 activation
Am J Physiol Lung Cell Mol Physiol, September 1, 1999; 277(3): L479 - L488.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
D. Fernandes, E. Guida, V. Koutsoubos, T. Harris, P. Vadiveloo, J. W. Wilson, and A. G. Stewart
Glucocorticoids Inhibit Proliferation, Cyclin D1 Expression, and Retinoblastoma Protein Phosphorylation, but Not Activity of the Extracellular-Regulated Kinases in Human Cultured Airway Smooth Muscle
Am. J. Respir. Cell Mol. Biol., July 1, 1999; 21(1): 77 - 88.
[Abstract] [Full Text]

Home page
 J. Appl. Physiol.Home page
H. L. Gillis and K. R. Lutchen
Airway remodeling in asthma amplifies heterogeneities in smooth muscle shortening causing hyperresponsiveness
J Appl Physiol, June 1, 1999; 86(6): 2001 - 2012.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
J C HOGG
Vascularity in asthmatic airways: relation to inhaled steroid dose
Thorax, April 1, 1999; 54(4): 283 - 283.
[Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. M. VIGNOLA, L. RICCOBONO, A. MIRABELLA, M. PROFITA, P. CHANEZ, V. BELLIA, G. MAUTINO, P. D'ACCARDI, J. BOUSQUET, and G. BONSIGNORE
Sputum Metalloproteinase-9/Tissue Inhibitor of Metalloproteinase-1 Ratio Correlates with Airflow Obstruction in Asthma and Chronic Bronchitis
Am. J. Respir. Crit. Care Med., December 1, 1998; 158(6): 1945 - 1950.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
V. Brusasco, E. Crimi, and R. Pellegrino
Airway hyperresponsiveness in asthma: not just a matter of airway inflammation
Thorax, November 1, 1998; 53(11): 992 - 998.
[Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
C. Y. SEOW, R. R. SCHELLENBERG, and P. D. PARE
Structural and Functional Changes in the Airway Smooth Muscle of Asthmatic Subjects
Am. J. Respir. Crit. Care Med., November 1, 1998; 158(2007): S179 - S186.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. J. HIRST and T. H. LEE
Airway Smooth Muscle as a Target of Glucocorticoid Action in the Treatment of Asthma
Am. J. Respir. Crit. Care Med., November 1, 1998; 158(2007): S201 - S206.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online