Journal of Applied Physiology Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 74: 2724-2728, 1993;
8750-7587/93 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Nishimura, M.
Right arrow Articles by Kawakami, Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nishimura, M.
Right arrow Articles by Kawakami, Y.

Journal of Applied Physiology, Vol 74, Issue 6 2724-2728, Copyright © 1993 by American Physiological Society

ARTICLES

Effect of theophylline on brain tissue oxygenation during normoxia and hypoxia in humans

M. Nishimura, A. Yoshioka, M. Yamamoto, Y. Akiyama, K. Miyamoto and Y. Kawakami
First Department of Medicine, School of Medicine, Hokkaido University, Sapporo, Japan.

Although theophylline, an adenosine receptor antagonist, is known to reduce cerebral blood flow, little clinical attention has been paid to this adverse effect. This study was designed to examine the effect of theophylline on brain tissue oxygenation for a wide range of arterial PO2 in healthy volunteers. Partial gas pressures and O2 saturation in an artery (SaO2) and the internal jugular vein (SjO2) were simultaneously measured while subjects (n = 6) were breathing room air and then exposed to two levels of isocapnic hypoxia (arterial PO2 = 60 and 45 Torr) before and after infusion of theophylline (6 mg/kg of aminophylline). For the same levels of arterial oxygenation, jugular vein PO2 markedly dropped, by 3-5 Torr, after theophylline infusion, as did SjO2, by as much as 6-10%, under the arterial PCO2, which was slightly lower by 1-2 Torr in the theophylline study. By use of the linear regression lines obtained from the relationship between SaO2 and SjO2 in each study, it was calculated that the SjO2 with theophylline, while SaO2 was 95, 90, and 80%, was comparable to that without theophylline when SaO2 was 81, 78, and 73%, respectively. On the basis of the assumption that partial gas pressures and SjO2 reflect brain tissue oxygenation, these data suggest that the effect of theophylline on brain tissue oxygenation should not be ignored in some clinical settings. The effects of chronic administration remain to be studied.


This article has been cited by other articles:


Home page
 Am. J. Respir. Crit. Care Med.Home page
I. Mitrouska, E. Kondili, G. Prinianakis, N. Siafakas, and D. Georgopoulos
Effects of Theophylline on Ventilatory Poststimulus Potentiation in Patients with Brain Damage
Am. J. Respir. Crit. Care Med., April 15, 2003; 167(8): 1124 - 1130.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
M. J. T. van de Ven, W. N. J. M. Colier, M. C. van der Sluijs, B. Oeseburg, P. Vis, and H. Folgering
Effects of Acetazolamide and Furosemide on Ventilation and Cerebral Blood Volume in Normocapnic and Hypercapnic Patients With COPD
Chest, February 1, 2002; 121(2): 383 - 392.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online