| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Journal of Applied Physiology, Vol 74, Issue 5 2225-2233, Copyright © 1993 by American Physiological Society
ARTICLES |
J. J. Vanoverschelde, B. Essamri, R. Vanbutsele, A. d'Hondt, J. R. Cosyns, J. R. Detry and J. A. Melin
Division of Cardiology, University of Louvain Medical School, Brussels, Belgium.
Previous studies have established that most of the heterogeneity in exercise capacity seen with sedentariness, aging, or physical training can be accounted for by individual differences in the maximal rate of total body oxygen consumption (VO2 max) during dynamic exercise. However, the factors that limit VO2 max in normal subjects remain disputed. To test the hypothesis that differences in left ventricular diastolic performance contribute to the heterogeneity of VO2 max seen in healthy subjects, 57 normal sedentary volunteers (36 +/- 13 yr, range 20-76 yr) and 9 endurance athletes (37 +/- 8 yr, range 26-51 yr) were studied. Aerobic capacity was estimated as VO2 max during a multistage dynamic cycle exercise protocol, whereas resting left ventricular systolic and diastolic function was assessed by two-dimensional and Doppler echocardiography. The relationship of the left ventricular functional indexes with VO2 max was investigated by stepwise multiple regression analysis. VO2 max ranged from 25 to 58 ml.kg-1 x min-1 in sedentary subjects and from 44 to 60 ml.kg-1 x min-1 in athletes. With univariate analysis, significant correlations were observed between VO2 max and age (r = -0.60), maximal heart rate (r = 0.48), maximal work load (r = 0.80), left ventricular volumes at both end diastole (r = 0.51) and end systole (r = 0.62), peak early transmitral filling velocities (r = 0.80), and the ratio of early to late transmitral filling velocities (r = 0.87).(ABSTRACT TRUNCATED AT 250 WORDS)
This article has been cited by other articles:
|
|
 |
|
  J. Grewal, R. B. McCully, G. C. Kane, C. Lam, and P. A. Pellikka Left Ventricular Function and Exercise Capacity JAMA, January 21, 2009; 301(3): 286 - 294. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. F. Renna, S. M. MacDonnell, P. O. Reger, D. L. Crabbe, S. R. Houser, and J. R. Libonati Relative systolic dysfunction in female spontaneously hypertensive rat myocardium J Appl Physiol, July 1, 2007; 103(1): 353 - 358. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Messika-Zeitoun, B. D. Johnson, V. Nkomo, J.-F. Avierinos, T. G. Allison, C. Scott, A. J. Tajik, and M. Enriquez-Sarano Cardiopulmonary Exercise Testing Determination of Functional Capacity in Mitral Regurgitation: Physiologic and Outcome Implications J. Am. Coll. Cardiol., June 20, 2006; 47(12): 2521 - 2527. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Libonati, Z. V. Kendrick, and S. R. Houser Sprint training improves postischemic, left ventricular diastolic performance J Appl Physiol, December 1, 2005; 99(6): 2121 - 2127. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Rovner, N. L. Greenberg, J. D. Thomas, and M. J. Garcia Relationship of diastolic intraventricular pressure gradients and aerobic capacity in patients with diastolic heart failure Am J Physiol Heart Circ Physiol, November 1, 2005; 289(5): H2081 - H2088. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Spinelli, M. Petretta, G. Verderame, G. Carbone, A. A. Venetucci, A. Petretta, W. Acampa, D. Bonaduce, A. Colao, and A. Cuocolo Left Ventricular Diastolic Function and Cardiac Performance during Exercise in Patients with Acromegaly J. Clin. Endocrinol. Metab., September 1, 2003; 88(9): 4105 - 4109. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Oxenham and N. Sharpe Cardiovascular aging and heart failure Eur J Heart Fail, August 1, 2003; 5(4): 427 - 434. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Baldi, J. L. Aoina, H. C. Oxenham, W. Bagg, and R. N. Doughty Reduced exercise arteriovenous O2 difference in Type 2 diabetes J Appl Physiol, March 1, 2003; 94(3): 1033 - 1038. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Lapu-Bula, A. Robert, D. Van Craeynest, A.-M. D'Hondt, B. L. Gerber, A. Pasquet, J. A. Melin, M. De Kock, and J.-L. Vanoverschelde Contribution of Exercise-Induced Mitral Regurgitation to Exercise Stroke Volume and Exercise Capacity in Patients With Left Ventricular Systolic Dysfunction Circulation, September 10, 2002; 106(11): 1342 - 1348. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Rowland, E. Mannie, and L. Gawle Dynamics of Left Ventricular Diastolic Filling During Exercise : A Doppler Echocardiographic Study of Boys 10 to 14 Years Old Chest, July 1, 2001; 120(1): 145 - 150. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Guazzi, D. A. Brenner, C. S. Apstein, and K. W. Saupe Exercise Intolerance in Rats With Hypertensive Heart Disease Is Associated With Impaired Diastolic Relaxation Hypertension, February 1, 2001; 37(2): 204 - 208. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
