Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 74: 1016-1023, 1993;
8750-7587/93 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wang, C. Z.
Right arrow Articles by Herndon, D. N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wang, C. Z.
Right arrow Articles by Herndon, D. N.

Journal of Applied Physiology, Vol 74, Issue 3 1016-1023, Copyright © 1993 by American Physiological Society

ARTICLES

Influence of detergent aerosol on lung microvascular permeability

C. Z. Wang, R. E. Barrow, C. S. Cox Jr, S. F. Yang and D. N. Herndon
Department of Surgery, University of Texas Medical Branch, Galveston 77550.

Noncardiogenic edema fluid often contains high levels of plasma proteins, which may inhibit the function of the lung surfactant complex and thus decrease interstitial hydrostatic pressures. We questioned whether, in the awake and standing animal, displacement of the alveolar surface lining would alter the permeability of the thin and sparsely supported pulmonary capillaries. Sheep prepared with lung lymph fistulae were given an aerosolized detergent (Det) to displace the lung surfactant complex. After the sheep were given Det, protein flux was significantly increased (P < 0.05). To validate the suggested permeability increase, pulmonary vein occluders were surgically implanted and experiments repeated with pulmonary arterial pressures elevated 10 mmHg above baseline. After 2 h of elevated pulmonary arterial pressure, lung lymph increased fivefold. At this time, lymph-to-plasma total protein concentration ratios for air and saline-plus-ethanol vehicle were significantly lower (P < 0.01) than baseline ratios (0.26 +/- 0.06 and 0.34 +/- 0.07, respectively). No significant difference could be shown in lymph-to-plasma ratios after the sheep were given Det. We conclude that disruption of the alveolar lining can cause a detectable increase in protein flux due, in part, to an increase in microvascular permeability.


This article has been cited by other articles:


Home page
 Am. J. Respir. Crit. Care Med.Home page
G. NAKOS, E. I. KITSIOULI, and M. E. LEKKA
Bronchoalveolar Lavage Alterations in Pulmonary Embolism
Am. J. Respir. Crit. Care Med., November 1, 1998; 158(5): 1504 - 1510.
[Abstract] [Full Text] [PDF]

Home page
 Drug Metab. Dispos.Home page
W. Taljanski, S. G. Pierzynowski, P. D. P. Lundin, B. R. Weström, S. Eirefelt, J. Podlesny, M. Dahlbäck, H. Siwinska-Golebiowska, and B. W. Karlsson
Pulmonary Delivery of Intratracheally Instilled and Aerosolized Cyclosporine A to Young and Adult Rats
Drug Metab. Dispos., August 1, 1997; 25(8): 917 - 920.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. SCHERMULY, T. SCHMEHL, A. GÜNTHER, F. GRIMMINGER, W. SEEGER, and D. WALMRATH
Ultrasonic Nebulization for Efficient Delivery of Surfactant in a Model of Acute Lung Injury . Impact on Gas Exchange
Am. J. Respir. Crit. Care Med., July 1, 1997; 156(2): 445 - 453.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
D. DREYFUSS and G. SAUMON
Ventilator-induced Lung Injury . Lessons from Experimental Studies
Am. J. Respir. Crit. Care Med., January 1, 1997; 157(1): 294 - 323.
[Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online