| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Journal of Applied Physiology, Vol 73, Issue 5 2004-2010, Copyright © 1992 by American Physiological Society
ARTICLES |
R. Wibom, E. Hultman, M. Johansson, K. Matherei, D. Constantin-Teodosiu and P. G. Schantz
Department of Clinical Chemistry II, Karolinska Institute, Huddinge, Sweden.
The adaptation of mitochondrial ATP production rate (MAPR) to training and detraining was evaluated in nine healthy men. Muscle samples (approximately 60 mg) were obtained before and after 6 wk of endurance training and after 3 wk of detraining. MAPR was measured in isolated mitochondria by a bioluminometric method. In addition, the activities of mitochondrial and glycolytic enzymes were determined in skeletal muscle. In response to training, MAPR increased by 70%, with a substrate combination of pyruvate + palmitoyl-L-carnitine + alpha-ketoglutarate + malate, by 50% with only pyruvate + malate, and by 92% with palmitoyl-L-carnitine + malate. With detraining MAPR decreased by 12-28% from the posttraining rate (although not significantly for all substrates). No differences were found when MAPR was related to the protein content in the mitochondrial fraction. The largest increase in mitochondrial enzyme activities induced by training was observed for cytochrome-c oxidase (78%), whereas succinate cytochrome c reductase showed only an 18% increase. The activity of citrate synthase increased by 40% and of glutamate dehydrogenase by 45%. Corresponding changes in maximal O2 uptake were a 9.6% increase by training and a 6.0% reversion after detraining. In conclusion, both MAPR and mitochondrial enzyme activities are shown to increase with endurance training and to decrease with detraining.
This article has been cited by other articles:
|
|
 |
|
  D. E. Befroy, K. F. Petersen, S. Dufour, G. F. Mason, D. L. Rothman, and G. I. Shulman Increased substrate oxidation and mitochondrial uncoupling in skeletal muscle of endurance-trained individuals PNAS, October 28, 2008; 105(43): 16701 - 16706. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Parikh, E. Nilsson, C. Ling, P. Poulsen, P. Almgren, H. Nittby, K.-F. Eriksson, A. Vaag, and L. C. Groop Molecular correlates for maximal oxygen uptake and type 1 fibers Am J Physiol Endocrinol Metab, June 1, 2008; 294(6): E1152 - E1159. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Petrovic, B. Buzadzic, A. Korac, A. Vasilijevic, A. Jankovic, K. Micunovic, and B. Korac Antioxidative defence alterations in skeletal muscle during prolonged acclimation to cold: role of L-arginine/NO-producing pathway J. Exp. Biol., January 1, 2008; 211(1): 114 - 120. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. A. Burgomaster, N. M. Cermak, S. M. Phillips, C. R. Benton, A. Bonen, and M. J. Gibala Divergent response of metabolite transport proteins in human skeletal muscle after sprint interval training and detraining Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2007; 292(5): R1970 - R1976. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Sahlin, M. Mogensen, M. Bagger, M. Fernstrom, and P. K. Pedersen The potential for mitochondrial fat oxidation in human skeletal muscle influences whole body fat oxidation during low-intensity exercise Am J Physiol Endocrinol Metab, January 1, 2007; 292(1): E223 - E230. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. S. Evangelista and J. E. Krieger Small gene effect and exercise training-induced cardiac hypertrophy in mice: an Ace gene dosage study Physiol Genomics, November 21, 2006; 27(3): 231 - 236. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Fredriksson, F. Hammarqvist, K. Strigard, K. Hultenby, O. Ljungqvist, J. Wernerman, and O. Rooyackers Derangements in mitochondrial metabolism in intercostal and leg muscle of critically ill patients with sepsis-induced multiple organ failure Am J Physiol Endocrinol Metab, November 1, 2006; 291(5): E1044 - E1050. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Walsh, R. B. Hooks, J. E. Hornyak, L. G. Koch, S. L. Britton, and M. C. Hogan Enhanced mitochondrial sensitivity to creatine in rats bred for high aerobic capacity J Appl Physiol, June 1, 2006; 100(6): 1765 - 1769. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Mogensen, M. Bagger, P. K. Pedersen, M. Fernstrom, and K. Sahlin Cycling efficiency in humans is related to low UCP3 content and to type I fibres but not to mitochondrial efficiency J. Physiol., March 15, 2006; 571(3): 669 - 681. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. P Brass, W. R Hiatt, and S. Green Skeletal muscle metabolic changes in peripheral arterial disease contribute to exercise intolerance: a point-counterpoint discussion Vascular Medicine, November 1, 2004; 9(4): 293 - 301. [Abstract] [PDF]
|
|
|
|
|
|
K. R. Short, B. Drew, and C. Leeuwenburgh Mitochondrial ATP measurements Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2004; 287(1): R243 - R246. [Full Text] [PDF]
|
|
|
|
|
|
P. J. LeBlanc, S. J. Peters, R. J. Tunstall, D. Cameron-Smith, and G. J. F. Heigenhauser Effects of aerobic training on pyruvate dehydrogenase and pyruvate dehydrogenase kinase in human skeletal muscle J. Physiol., June 1, 2004; 557(2): 559 - 570. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Nishida, K. Tokuyama, S. Nagasaka, Y. Higaki, Y. Shirai, A. Kiyonaga, M. Shindo, I. Kusaka, T. Nakamura, S. Ishibashi, et al. Effect of Moderate Exercise Training on Peripheral Glucose Effectiveness, Insulin Sensitivity, and Endogenous Glucose Production in Healthy Humans Estimated by a Two-Compartment-Labeled Minimal Model Diabetes, February 1, 2004; 53(2): 315 - 320. [Abstract] [Full Text]
|
|
|
|
 |
|
 B. CANNON and J. NEDERGAARD Brown Adipose Tissue: Function and Physiological Significance Physiol Rev, January 1, 2004; 84(1): 277 - 359. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Morio, J.-F. Hocquette, C. Montaurier, Y. Boirie, C. Bouteloup-Demange, C. McCormack, N. Fellmann, B. Beaufrere, and P. Ritz Muscle fatty acid oxidative capacity is a determinant of whole body fat oxidation in elderly people Am J Physiol Endocrinol Metab, January 1, 2001; 280(1): E143 - E149. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. P Brass and W. R Hiatt Acquired skeletal muscle metabolic myopathy in atherosclerotic peripheral arterial disease Vascular Medicine, February 1, 2000; 5(1): 55 - 59. [Abstract] [PDF]
|
|
|
|
|
|
E. C. Starritt, D. Angus, and M. Hargreaves Effect of short-term training on mitochondrial ATP production rate in human skeletal muscle J Appl Physiol, February 1, 1999; 86(2): 450 - 454. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. MacDougall, A. L. Hicks, J. R. MacDonald, R. S. McKelvie, H. J. Green, and K. M. Smith Muscle performance and enzymatic adaptations to sprint interval training J Appl Physiol, June 1, 1998; 84(6): 2138 - 2142. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. McAllister, B. L. Reiter, J. F. Amann, and M. H. Laughlin Skeletal muscle biochemical adaptations to exercise training in miniature swine J Appl Physiol, June 1, 1997; 82(6): 1862 - 1868. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
