Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 73: 1805-1809, 1992;
8750-7587/92 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Reid, M. B.
Right arrow Articles by Entman, M. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Reid, M. B.
Right arrow Articles by Entman, M. L.

Journal of Applied Physiology, Vol 73, Issue 5 1805-1809, Copyright © 1992 by American Physiological Society

ARTICLES

Reactive oxygen in skeletal muscle. II. Extracellular release of free radicals

M. B. Reid, T. Shoji, M. R. Moody and M. L. Entman
Department of Medicine, Baylor College of Medicine, Houston, Texas 77030.

We have tested the hypothesis that diaphragm muscle fibers release superoxide anion radicals (O2-.) into the extracellular space. Fiber bundles were isolated from rat diaphragm and incubated in Krebs-Ringer solution containing cytochrome c (10(-5) M), a standard assay for O2-.. Bundles were either passive or active, i.e., directly stimulated to contract rhythmically. After 1 h, absorbance of reduced cytochrome c in the incubation medium was measured at 550 nm. Absorbance was greater in medium exposed to passive muscle than in medium without muscle (P < 0.01), indicating O2-. release by passive muscle. Absorbance was greater in medium exposed to active muscle than in that exposed to passive muscle (P < 0.01), an increase inhibited by superoxide dismutase (10(3) U/ml). Active bundles fatigued; bundles developing the lowest final stresses produced the greatest absorbance increases (P < 0.001), suggesting that the magnitude of fatigue was inversely related to O2-. release. We conclude that O2-. is released by diaphragm myocytes into the interstitium and surrounding medium, a process accelerated by fatiguing muscular contractions.


This article has been cited by other articles:


Home page
 Physiol. Rev.Home page
S. K. Powers and M. J. Jackson
Exercise-Induced Oxidative Stress: Cellular Mechanisms and Impact on Muscle Force Production
Physiol Rev, October 1, 2008; 88(4): 1243 - 1276.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
L. F. Ferreira and M. B. Reid
Muscle-derived ROS and thiol regulation in muscle fatigue
J Appl Physiol, March 1, 2008; 104(3): 853 - 860.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
M. D. Delp, B. J. Behnke, S. A. Spier, G. Wu, and J. M. Muller-Delp
Ageing diminishes endothelium-dependent vasodilatation and tetrahydrobiopterin content in rat skeletal muscle arterioles
J. Physiol., February 15, 2008; 586(4): 1161 - 1168.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
Y. Lecarpentier
Physiological role of free radicals in skeletal muscles
J Appl Physiol, December 1, 2007; 103(6): 1917 - 1918.
[Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. J. Jackson, D. Pye, and J. Palomero
The production of reactive oxygen and nitrogen species by skeletal muscle
J Appl Physiol, April 1, 2007; 102(4): 1664 - 1670.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. Vassilakopoulos and S. N. A. Hussain
Ventilatory muscle activation and inflammation: cytokines, reactive oxygen species, and nitric oxide
J Appl Physiol, April 1, 2007; 102(4): 1687 - 1695.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
C. van der Poel, J. N. Edwards, W. A. Macdonald, and D. G. Stephenson
Mitochondrial superoxide production in skeletal muscle fibers of the rat and decreased fiber excitability
Am J Physiol Cell Physiol, April 1, 2007; 292(4): C1353 - C1360.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
K. Bedard and K.-H. Krause
The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology
Physiol Rev, January 1, 2007; 87(1): 245 - 313.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
W. Derave, N. Straumann, R. A. Olek, and P. Hespel
Electrolysis stimulates creatine transport and transporter cell surface expression in incubated mouse skeletal muscle: potential role of ROS
Am J Physiol Endocrinol Metab, December 1, 2006; 291(6): E1250 - E1257.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. Hidalgo, G. Sanchez, G. Barrientos, and P. Aracena-Parks
A Transverse Tubule NADPH Oxidase Activity Stimulates Calcium Release from Isolated Triads via Ryanodine Receptor Type 1 S -Glutathionylation
J. Biol. Chem., September 8, 2006; 281(36): 26473 - 26482.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Sports. Med.Home page
B Skof, V Strojnik, and G Millet
Neuromuscular fatigue and recovery dynamics following prolonged continuous run at anaerobic threshold * Commentary.
Br. J. Sports Med., March 1, 2006; 40(3): 219 - 222.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
T. R. Moopanar and D. G. Allen
The activity-induced reduction of myofibrillar Ca2+ sensitivity in mouse skeletal muscle is reversed by dithiothreitol
J. Physiol., February 15, 2006; 571(1): 191 - 200.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
M.-C. Gomez-Cabrera, C. Borras, F. V Pallardo, J. Sastre, L. L. Ji, and J. Vina
Decreasing xanthine oxidase-mediated oxidative stress prevents useful cellular adaptations to exercise in rats
J. Physiol., August 15, 2005; 567(1): 113 - 120.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
L. Zuo and T. L. Clanton
Reactive oxygen species formation in the transition to hypoxia in skeletal muscle
Am J Physiol Cell Physiol, July 1, 2005; 289(1): C207 - C216.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
J. N. Dentel, S. G. Blanchard, D. P. Ankrapp, L. R. McCabe, and R. W. Wiseman
Inhibition of cross-bridge formation has no effect on contraction-associated phosphorylation of p38 MAPK in mouse skeletal muscle
Am J Physiol Cell Physiol, April 1, 2005; 288(4): C824 - C830.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. G. Tidball
Inflammatory processes in muscle injury and repair
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2005; 288(2): R345 - R353.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
F McArdle, S Spiers, H Aldemir, A Vasilaki, A Beaver, L Iwanejko, A McArdle, and M. J Jackson
Preconditioning of skeletal muscle against contraction-induced damage: the role of adaptations to oxidants in mice
J. Physiol., November 15, 2004; 561(1): 233 - 244.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
L. L. JI, M-C. GOMEZ-CABRERA, N. STEINHAFEL, and J. VINA
Acute exercise activates nuclear factor (NF)-{kappa}B signaling pathway in rat skeletal muscle
FASEB J, October 1, 2004; 18(13): 1499 - 1506.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
S. Arbogast and M. B. Reid
Oxidant activity in skeletal muscle fibers is influenced by temperature, CO2 level, and muscle-derived nitric oxide
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2004; 287(4): R698 - R705.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
L. Zuo, F. L. Christofi, V. P. Wright, S. Bao, and T. L. Clanton
Lipoxygenase-dependent superoxide release in skeletal muscle
J Appl Physiol, August 1, 2004; 97(2): 661 - 668.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
T. Toyoda, T. Hayashi, L. Miyamoto, S. Yonemitsu, M. Nakano, S. Tanaka, K. Ebihara, H. Masuzaki, K. Hosoda, G. Inoue, et al.
Possible involvement of the {alpha}1 isoform of 5'AMP-activated protein kinase in oxidative stress-stimulated glucose transport in skeletal muscle
Am J Physiol Endocrinol Metab, July 1, 2004; 287(1): E166 - E173.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
S. Mak and G. E. Newton
Redox modulation of the inotropic response to dobutamine is impaired in patients with heart failure
Am J Physiol Heart Circ Physiol, February 1, 2004; 286(2): H789 - H795.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
I. Medved, M. J. Brown, A. R. Bjorksten, and M. J. McKenna
Effects of intravenous N-acetylcysteine infusion on time to fatigue and potassium regulation during prolonged cycling exercise
J Appl Physiol, January 1, 2004; 96(1): 211 - 217.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
S. Matalon, K. M. Hardiman, L. Jain, D. C. Eaton, M. Kotlikoff, J. P. Eu, J. Sun, G. Meissner, and J. S. Stamler
Regulation of ion channel structure and function by reactive oxygen-nitrogen species
Am J Physiol Lung Cell Mol Physiol, December 1, 2003; 285(6): L1184 - L1189.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
Y.-P. Li, Y. Chen, A. S. Li, and M. B. Reid
Hydrogen peroxide stimulates ubiquitin-conjugating activity and expression of genes for specific E2 and E3 proteins in skeletal muscle myotubes
Am J Physiol Cell Physiol, October 1, 2003; 285(4): C806 - C812.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
I. Medved, M. J. Brown, A. R. Bjorksten, J. A. Leppik, S. Sostaric, and M. J. McKenna
N-acetylcysteine infusion alters blood redox status but not time to fatigue during intense exercise in humans
J Appl Physiol, April 1, 2003; 94(4): 1572 - 1582.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
A.G.N. Agusti, A. Noguera, J. Sauleda, E. Sala, J. Pons, and X. Busquets
Systemic effects of chronic obstructive pulmonary disease
Eur. Respir. J., February 1, 2003; 21(2): 347 - 360.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
X. Zhu, L. M. A. Heunks, H. A. Machiels, L. Ennen, and P. N. R. Dekhuijzen
Effects of modulation of nitric oxide on rat diaphragm isotonic contractility during hypoxia
J Appl Physiol, February 1, 2003; 94(2): 612 - 620.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
D. JAVESGHANI, S. A. MAGDER, E. BARREIRO, M. T. QUINN, and S. N. A. HUSSAIN
Molecular Characterization of a Superoxide-Generating NAD(P)H Oxidase in the Ventilatory Muscles
Am. J. Respir. Crit. Care Med., February 1, 2002; 165(3): 412 - 418.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
L. M. A. Heunks, H. A. Machiels, R. de Abreu, X. Ping Zhu, H. F. M. van der Heijden, and P. N. R. Dekhuijzen
Free radicals in hypoxic rat diaphragm contractility: no role for xanthine oxidase
Am J Physiol Lung Cell Mol Physiol, December 1, 2001; 281(6): L1402 - L1412.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
T.-X. JIANG, W. DARLENE REID, and J. D. ROAD
Free Radical Scavengers and Diaphragm Injury Following Inspiratory Resistive Loading
Am. J. Respir. Crit. Care Med., October 1, 2001; 164(7): 1288 - 1294.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. Khassaf, R. B. Child, A. McArdle, D. A. Brodie, C. Esanu, and M. J. Jackson
Time course of responses of human skeletal muscle to oxidative stress induced by nondamaging exercise
J Appl Physiol, March 1, 2001; 90(3): 1031 - 1035.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. B. Reid
Plasticity in Skeletal, Cardiac, and Smooth Muscle: Invited Review: Redox modulation of skeletal muscle contraction: what we know and what we don't
J Appl Physiol, February 1, 2001; 90(2): 724 - 731.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
L. A. Callahan, Z. W. She, and T. M. Nosek
Superoxide, hydroxyl radical, and hydrogen peroxide effects on single-diaphragm fiber contractile apparatus
J Appl Physiol, January 1, 2001; 90(1): 45 - 54.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
L. Zuo, F. L. Christofi, V. P. Wright, C. Y. Liu, A. J. Merola, L. J. Berliner, and T. L. Clanton
Intra- and extracellular measurement of reactive oxygen species produced during heat stress in diaphragm muscle
Am J Physiol Cell Physiol, October 1, 2000; 279(4): C1058 - C1066.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
C. K Sen and L. Packer
Thiol homeostasis and supplements in physical exercise
Am. J. Clinical Nutrition, August 1, 2000; 72(2): 653S - 669.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
L. M A Heunks and P N R. Dekhuijzen
Respiratory muscle function and free radicals: from cell to COPD
Thorax, August 1, 2000; 55(8): 704 - 716.
[Full Text]

Home page
 J. Appl. Physiol.Home page
L. M. A. Heunks, A. Bast, C. L. A. van Herwaarden, G. R. M. M. Haenen, and P. N. R. Dekhuijzen
Effects of emphysema and training on glutathione oxidation in the hamster diaphragm
J Appl Physiol, June 1, 2000; 88(6): 2054 - 2061.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
D. A. STOFAN, L. A. CALLAHAN, A. F. DiMARCO, D. E. NETHERY, and G. S. SUPINSKI
Modulation of Release of Reactive Oxygen Species by the Contracting Diaphragm
Am. J. Respir. Crit. Care Med., March 1, 2000; 161(3): 891 - 898.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. P. Moore, J.-Z. Zhang, and S. L. Hamilton
A Role for Cysteine 3635 of RYR1 in Redox Modulation and Calmodulin Binding
J. Biol. Chem., December 24, 1999; 274(52): 36831 - 36834.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
T. L. Clanton, L. Zuo, and P. Klawitter
Oxidants and Skeletal Muscle Function: Physiologic and Pathophysiologic Implications
Experimental Biology and Medicine, December 1, 1999; 222(3): 253 - 262.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
L. M. A. Heunks, J. Vina, C. L. A. van Herwaarden, H. T. M. Folgering, A. Gimeno, and P. N. R. Dekhuijzen
Xanthine oxidase is involved in exercise-induced oxidative stress in chronic obstructive pulmonary disease
Am J Physiol Regulatory Integrative Comp Physiol, December 1, 1999; 277(6): R1697 - R1704.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G. Supinski, D. Nethery, D. Stofan, L. Szweda, and A. DiMarco
Oxypurinol administration fails to prevent free radical-mediated lipid peroxidation during loaded breathing
J Appl Physiol, September 1, 1999; 87(3): 1123 - 1131.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
E. SCHMID, A. HOTZ-WAGENBLATT, V. HACK, and W. DRÖGE
Phosphorylation of the insulin receptor kinase by phosphocreatine in combination with hydrogen peroxide: the structural basis of redox priming
FASEB J, September 1, 1999; 13(12): 1491 - 1500.
[Abstract] [Full Text]

Home page
 J. Appl. Physiol.Home page
G. Supinski, D. Stofan, L. A. Callahan, D. Nethery, T. M. Nosek, and A. DiMarco
Peroxynitrite induces contractile dysfunction and lipid peroxidation in the diaphragm
J Appl Physiol, August 1, 1999; 87(2): 783 - 791.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G. Supinski, D. Nethery, D. Stofan, W. Hirschfield, and A. DiMarco
Diaphragmatic lipid peroxidation in chronically loaded rats
J Appl Physiol, February 1, 1999; 86(2): 651 - 658.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
Y.-p. Li, R. J. Schwartz, I. D. Waddell, B. R. Holloway, and M. B. Reid
Skeletal muscle myocytes undergo protein loss and reactive oxygen-mediated NF-{kappa}B activation in response to tumor necrosis factor {alpha}
FASEB J, July 1, 1998; 12(10): 871 - 880.
[Abstract] [Full Text]

Home page
 J. Appl. Physiol.Home page
P. Mohanraj, A. J. Merola, V. P. Wright, and T. L. Clanton
Antioxidants protect rat diaphragmatic muscle function under hypoxic conditions
J Appl Physiol, June 1, 1998; 84(6): 1960 - 1966.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. M. Lawler, Z. Hu, and W. S. Barnes
Effect of reactive oxygen species on K+ contractures in the rat diaphragm
J Appl Physiol, March 1, 1998; 84(3): 948 - 953.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Wu, B. Aghdasi, S. J. Dou, J. Z. Zhang, S. Q. Liu, and S. L. Hamilton
Functional Interactions between Cytoplasmic Domains of the Skeletal Muscle Ca2+ Release Channel
J. Biol. Chem., October 3, 1997; 272(40): 25051 - 25061.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. Booth, M. J. McKenna, P. A. Ruell, T. H. Gwinn, G. M. Davis, M. W. Thompson, A. R. Harmer, S. K. Hunter, and J. R. Sutton
Impaired calcium pump function does not slow relaxation in human skeletal muscle after prolonged exercise
J Appl Physiol, August 1, 1997; 83(2): 511 - 521.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. McGuire, M. F. Carey, and J. J. O'Connor
Almitrine and doxapram decrease fatigue and increase subsequent recovery in isolated rat diaphragm
J Appl Physiol, July 1, 1997; 83(1): 52 - 58.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. C. KOLBECK, Z.-W. SHE, L. A. CALLAHAN, and A. T. M. NOSEK
Increased Superoxide Production during Fatigue in the Perfused Rat Diaphragm
Am. J. Respir. Crit. Care Med., July 1, 1997; 156(1): 140 - 145.
[Abstract] [Full Text]

Home page
 J. Appl. Physiol.Home page
G. S. Supinski, D. Stofan, R. Ciufo, and A. Dimarco
N-acetylcysteine administration alters the response to inspiratory loading in oxygen-supplemented rats
J Appl Physiol, April 1, 1997; 82(4): 1119 - 1125.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
B. Aghdasi, J.-Z. Zhang, Y. Wu, M. B. Reid, and S. L. Hamilton
Multiple Classes of Sulfhydryls Modulate the Skeletal Muscle Ca2+ Release Channel
J. Biol. Chem., February 7, 1997; 272(6): 3739 - 3748.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online