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J Appl Physiol 73: 1797-1804, 1992;
8750-7587/92 $5.00
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Journal of Applied Physiology, Vol 73, Issue 5 1797-1804, Copyright © 1992 by American Physiological Society

ARTICLES

Reactive oxygen in skeletal muscle. I. Intracellular oxidant kinetics and fatigue in vitro

M. B. Reid, K. E. Haack, K. M. Franchek, P. A. Valberg, L. Kobzik and M. S. West
Department of Medicine, Baylor College of Medicine, Houston, Texas 77030.

We hypothesized that muscle fiber bundles produce reactive oxygen intermediates and that reactive oxidant species contribute to muscular fatigue in vitro. Fiber bundles from rat diaphragm were mounted in chambers containing Krebs-Ringer solution. In studies of intracellular oxidant kinetics, bundles were loaded with 2',7'-dichlorofluorescin, a fluorochrome that emits at 520 nm when oxidized; emissions were quantified using a fluorescence microscope. Emissions from unstimulated muscles increased over time (P < 0.001). Accumulation of fluorescence was slowed by addition of catalase (P < 0.001) or superoxide dismutase (P < 0.001) and was accelerated by repetitive muscular contraction (P < 0.05). To determine effects of reactive oxygen intermediates on fatigue, curarized bundles were stimulated to contract isometrically; force was measured. Catalase, superoxide dismutase, and dimethyl sulfoxide were screened for effects on low- and high-frequency fatigue. Antioxidants inhibited low-frequency fatigue [after 5 min of repetitive contractions, force at 30 Hz was 20% greater than control (P < 0.015)] and increased the variability of fatigue at 30 Hz (P < 0.03). Antioxidants did not alter high-frequency (200-Hz) fatigue. We conclude that 1) diaphragm fiber bundles produce reactive oxygen intermediates, including O2-. and H2O2; 2) muscular contraction increases intracellular oxidant levels; and 3) reactive oxygen intermediates promote low-frequency fatigue in this preparation.


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Y.-p. Li, R. J. Schwartz, I. D. Waddell, B. R. Holloway, and M. B. Reid
Skeletal muscle myocytes undergo protein loss and reactive oxygen-mediated NF-{kappa}B activation in response to tumor necrosis factor {alpha}
FASEB J, July 1, 1998; 12(10): 871 - 880.
[Abstract] [Full Text]

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 J. Appl. Physiol.Home page
P. Mohanraj, A. J. Merola, V. P. Wright, and T. L. Clanton
Antioxidants protect rat diaphragmatic muscle function under hypoxic conditions
J Appl Physiol, June 1, 1998; 84(6): 1960 - 1966.
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 J. Physiol.Home page
F. H Andrade, M. B Reid, D. G Allen, and H. Westerblad
Effect of hydrogen peroxide and dithiothreitol on contractile function of single skeletal muscle fibres from the mouse
J. Physiol., June 1, 1998; 509(2): 565 - 575.
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 Am. J. Physiol. Cell Physiol.Home page
T. Oba, T. Ishikawa, and M. Yamaguchi
Sulfhydryls associated with H2O2-induced channel activation are on luminal side of ryanodine receptors
Am J Physiol Cell Physiol, April 1, 1998; 274(4): C914 - C921.
[Abstract] [Full Text] [PDF]

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 J. Appl. Physiol.Home page
J. M. Lawler, Z. Hu, and W. S. Barnes
Effect of reactive oxygen species on K+ contractures in the rat diaphragm
J Appl Physiol, March 1, 1998; 84(3): 948 - 953.
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 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
L.-E. Chen, A. V. Seaber, R. M. Nasser, J. S. Stamler, and J. R. Urbaniak
Effects of S-nitroso-N-acetylcysteine on contractile function of reperfused skeletal muscle
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 1998; 274(3): R822 - R829.
[Abstract] [Full Text] [PDF]

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 J. Appl. Physiol.Home page
T. G. Favero, D. Colter, P. F. Hooper, and J. J. Abramson
Hypochlorous acid inhibits Ca2+-ATPase from skeletal muscle sarcoplasmic reticulum
J Appl Physiol, February 1, 1998; 84(2): 425 - 430.
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 Am. J. Respir. Crit. Care Med.Home page
S. OH-ISHI, T. KIZAKI, T. OOKAWARA, T. SAKURAI, T. IZAWA, N. NAGATA, and H. OHNO
Endurance Training Improves the Resistance of Rat Diaphragm to Exercise-induced Oxidative Stress
Am. J. Respir. Crit. Care Med., November 1, 1997; 156(5): 1579 - 1585.
[Abstract] [Full Text]

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 J. Biol. Chem.Home page
B. Aghdasi, M. B. Reid, and S. L. Hamilton
Nitric Oxide Protects the Skeletal Muscle Ca2+ Release Channel from Oxidation Induced Activation
J. Biol. Chem., October 10, 1997; 272(41): 25462 - 25467.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
Y. Wu, B. Aghdasi, S. J. Dou, J. Z. Zhang, S. Q. Liu, and S. L. Hamilton
Functional Interactions between Cytoplasmic Domains of the Skeletal Muscle Ca2+ Release Channel
J. Biol. Chem., October 3, 1997; 272(40): 25051 - 25061.
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 J. Appl. Physiol.Home page
W. J. Perkins, Y.-S. Han, and G. C. Sieck
Skeletal muscle force and actomyosin ATPase activity reduced by nitric oxide donor
J Appl Physiol, October 1, 1997; 83(4): 1326 - 1332.
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 J. Appl. Physiol.Home page
J. Booth, M. J. McKenna, P. A. Ruell, T. H. Gwinn, G. M. Davis, M. W. Thompson, A. R. Harmer, S. K. Hunter, and J. R. Sutton
Impaired calcium pump function does not slow relaxation in human skeletal muscle after prolonged exercise
J Appl Physiol, August 1, 1997; 83(2): 511 - 521.
[Abstract] [Full Text] [PDF]

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 J. Appl. Physiol.Home page
M. McGuire, M. F. Carey, and J. J. O'Connor
Almitrine and doxapram decrease fatigue and increase subsequent recovery in isolated rat diaphragm
J Appl Physiol, July 1, 1997; 83(1): 52 - 58.
[Abstract] [Full Text] [PDF]

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 Am. J. Respir. Crit. Care Med.Home page
R. C. KOLBECK, Z.-W. SHE, L. A. CALLAHAN, and A. T. M. NOSEK
Increased Superoxide Production during Fatigue in the Perfused Rat Diaphragm
Am. J. Respir. Crit. Care Med., July 1, 1997; 156(1): 140 - 145.
[Abstract] [Full Text]

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 J. Appl. Physiol.Home page
G. S. Supinski, D. Stofan, R. Ciufo, and A. Dimarco
N-acetylcysteine administration alters the response to inspiratory loading in oxygen-supplemented rats
J Appl Physiol, April 1, 1997; 82(4): 1119 - 1125.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
B. Aghdasi, J.-Z. Zhang, Y. Wu, M. B. Reid, and S. L. Hamilton
Multiple Classes of Sulfhydryls Modulate the Skeletal Muscle Ca2+ Release Channel
J. Biol. Chem., February 7, 1997; 272(6): 3739 - 3748.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
T. G. Favero, A. C. Zable, and J. J. Abramson
Hydrogen Peroxide Stimulates the Ca[IMAGE] Release Channel from Skeletal Muscle Sarcoplasmic Reticulum
J. Biol. Chem., October 27, 1995; 270(43): 25557 - 25563.
[Abstract] [Full Text] [PDF]

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 Circ. Res.Home page
G. D. Thomas, W. Zhang, and R. G. Victor
Impaired Modulation of Sympathetic Vasoconstriction in Contracting Skeletal Muscle of Rats With Chronic Myocardial Infarctions : Role of Oxidative Stress
Circ. Res., April 27, 2001; 88(8): 816 - 823.
[Abstract] [Full Text] [PDF]


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