Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 73: 1743-1748, 1992;
8750-7587/92 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Garpestad, E.
Right arrow Articles by Weiss, J. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Garpestad, E.
Right arrow Articles by Weiss, J. W.

Journal of Applied Physiology, Vol 73, Issue 5 1743-1748, Copyright © 1992 by American Physiological Society

ARTICLES

Stroke volume and cardiac output decrease at termination of obstructive apneas

E. Garpestad, H. Katayama, J. A. Parker, J. Ringler, J. Lilly, T. Yasuda, R. H. Moore, H. W. Strauss and J. W. Weiss
Charles A. Dana Institute, Beth Israel Hospital, Boston, Massachusetts.

Patients with obstructive sleep apnea (OSA) experience repetitive nocturnal oscillations of systemic arterial pressure that occur in association with changes in respiration and changes in sleep state. To investigate cardiac function during the cycle of obstruction (apnea) and resumption of ventilation (recovery), we continuously measured left ventricular stroke volume (LVSV) and mean arterial blood pressure (MAP) during non-rapid-eye-movement sleep in six males with severe OSA (apnea/hypopnea index > or = 30 events/h associated with oxygen saturation < 82%). LVSV was assessed continuously using an ambulatory ventricular function monitor (VEST; Capintec). The apnea-recovery cycle was divided into three phases: 1) early apnea (EA), 2) late apnea (LA), and 3) recovery (Rec). In all subjects recovery was associated with an abrupt decrease in LVSV [54.0 +/- 14.5 (SD) ml] compared with either EA (91.4 +/- 14.7 ml; P < 0.001) or LA (77.1 +/- 15.2 ml; P < 0.005). Although heart rate increased with recovery, the increase was not sufficient to compensate for the decrease in LVSV so that cardiac output (CO) fell (EA: 6,247 +/- 739 ml/min; LA: 5,741 +/- 1,094 ml/min; Rec: 4,601 +/- 1,249 ml/min; EA vs. Rec, P < 0.01; LA vs. Rec, P < 0.025). Recovery was also associated with a significant increase in MAP. We speculate that such abrupt decreases in LVSV and CO at apnea termination, occurring coincident with the nadir of oxygen saturation, may further compromise tissue oxygen delivery.


This article has been cited by other articles:


Home page
 NEJMHome page
R. C. Basner
Continuous Positive Airway Pressure for Obstructive Sleep Apnea
N. Engl. J. Med., April 26, 2007; 356(17): 1751 - 1758.
[Full Text] [PDF]

Home page
 ChestHome page
A. G. Kaditis, E. I. Alexopoulos, F. Hatzi, E. Kostadima, M. Kiaffas, E. Zakynthinos, and K. Gourgoulianis
Overnight change in brain natriuretic Peptide levels in children with sleep-disordered breathing.
Chest, November 1, 2006; 130(5): 1377 - 1384.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
P Gordon and M H Sanders
Sleep {middle dot} 7: Positive airway pressure therapy for obstructive sleep apnoea/hypopnoea syndrome
Thorax, January 1, 2005; 60(1): 68 - 75.
[Abstract] [Full Text] [PDF]

Home page
 Br J OphthalmolHome page
P O Lundmark, G E Trope, and J G Flanagan
The effect of simulated obstructive apnoea on intraocular pressure and pulsatile ocular blood flow in healthy young adults
Br J Ophthalmol, November 1, 2003; 87(11): 1363 - 1369.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. S. Amin, T. R. Kimball, J. A. Bean, J. L. Jeffries, J. P. Willging, R. T. Cotton, S. A. Witt, B. J. Glascock, and S. R. Daniels
Left Ventricular Hypertrophy and Abnormal Ventricular Geometry in Children and Adolescents with Obstructive Sleep Apnea
Am. J. Respir. Crit. Care Med., May 15, 2002; 165(10): 1395 - 1399.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
V. A. IMADOJEMU, K. GLEESON, K. S. GRAY, L. I. SINOWAY, and U. A. LEUENBERGER
Obstructive Apnea during Sleep Is Associated with Peripheral Vasoconstriction
Am. J. Respir. Crit. Care Med., January 1, 2002; 165(1): 61 - 66.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A. Anand, S. Remsburg-Sailor, S. H. Launois, and J. W. Weiss
Peripheral vascular resistance increases after termination of obstructive apneas
J Appl Physiol, November 1, 2001; 91(5): 2359 - 2365.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
U. A. Leuenberger, J. C. Hardy, M. D. Herr, K. S. Gray, and L. I. Sinoway
Hypoxia augments apnea-induced peripheral vasoconstriction in humans
J Appl Physiol, April 1, 2001; 90(4): 1516 - 1522.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
H. Kraiczi, K. Caidahl, A. Samuelsson, Y. Peker, and J. Hedner
Impairment of Vascular Endothelial Function and Left Ventricular Filling : Association With the Severity of Apnea-Induced Hypoxemia During Sleep
Chest, April 1, 2001; 119(4): 1085 - 1091.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
E. SHAHAR, C. W. WHITNEY, S. REDLINE, E. T. LEE, A. B. NEWMAN, F. JAVIER NIETO, G. T. O'CONNOR, L. L. BOLAND, J. E. SCHWARTZ, and J. M. SAMET
Sleep-disordered Breathing and Cardiovascular Disease . Cross-sectional Results of the Sleep Heart Health Study
Am. J. Respir. Crit. Care Med., January 1, 2001; 163(1): 19 - 25.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. S. M. IP, B. LAM, L.-Y. CHAN, L. ZHENG, K. W. T. TSANG, P. C. W. FUNG, and W.-K. LAM
Circulating Nitric Oxide Is Suppressed in Obstructive Sleep Apnea and Is Reversed by Nasal Continuous Positive Airway Pressure
Am. J. Respir. Crit. Care Med., December 1, 2000; 162(6): 2166 - 2171.
[Abstract] [Full Text]

Home page
 NEJMHome page
P. E. Peppard, T. Young, M. Palta, and J. Skatrud
Prospective Study of the Association between Sleep-Disordered Breathing and Hypertension
N. Engl. J. Med., May 11, 2000; 342(19): 1378 - 1384.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
H. Schneider, C. D. Schaub, C. A. Chen, K. A. Andreoni, A. R. Schwartz, P. L. Smith, J. L. Robotham, and C. P. O'Donnell
Effects of arousal and sleep state on systemic and pulmonary hemodynamics in obstructive apnea
J Appl Physiol, March 1, 2000; 88(3): 1084 - 1092.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
H. Schneider, C. D. Schaub, C. A. Chen, K. A. Andreoni, A. R. Schwartz, P. L. Smith, J. L. Robotham, and C. P. O'Donnell
Neural and local effects of hypoxia on cardiovascular responses to obstructive apnea
J Appl Physiol, March 1, 2000; 88(3): 1093 - 1102.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. D. PARKER, D. BROOKS, L. F. KOZAR, C. L. RENDER-TEIXEIRA, R. L. HORNER, T. DOUGLAS BRADLEY, and E. A. PHILLIPSON
Acute and Chronic Effects of Airway Obstruction on Canine Left Ventricular Performance
Am. J. Respir. Crit. Care Med., December 1, 1999; 160(6): 1888 - 1896.
[Abstract] [Full Text]

Home page
 J. Appl. Physiol.Home page
B. Kesler, A. Anand, S. H. Launois, and J. W. Weiss
Drug-induced arterial pressure elevation is associated with arousal from NREM sleep in normal volunteers
J Appl Physiol, September 1, 1999; 87(3): 897 - 901.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
R. J O Davies
Cardiovascular aspects of obstructive sleep apnoea and their relevance to the assessment of the efficacy of nasal continuous positive airway pressure therapy
Thorax, May 1, 1998; 53(5): 416 - 418.
[Full Text]

Home page
 J. Appl. Physiol.Home page
C. R. Wilson, S. Manchanda, D. Crabtree, J. B. Skatrud, and J. A. Dempsey
An induced blood pressure rise does not alter upper airway resistance in sleeping humans
J Appl Physiol, January 1, 1998; 84(1): 269 - 276.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. Katragadda, A. Xie, D. Puleo, J. B. Skatrud, and B. J. Morgan
Neural mechanism of the pressor response to obstructive and nonobstructive apnea
J Appl Physiol, December 1, 1997; 83(6): 2048 - 2054.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
H. Schneider, C. D. Schaub, K. A. Andreoni, A. R. Schwartz, P. L. Smith, J. L. Robotham, and C. P. O'Donnell
Systemic and pulmonary hemodynamic responses to normal and obstructed breathing during sleep
J Appl Physiol, November 1, 1997; 83(5): 1671 - 1680.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
L. Chen and S. M. Scharf
Comparative hemodynamic effects of periodic obstructive and simulated central apneas in sedated pigs
J Appl Physiol, August 1, 1997; 83(2): 485 - 494.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. Zinkovska and D. A. Kirby
Intracerebroventricular propranolol prevented vascular resistance increases on arousal from sleep apnea
J Appl Physiol, May 1, 1997; 82(5): 1637 - 1643.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online