Journal of Applied Physiology Track the topics, authors and articles important to you
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 73: 1671-1675, 1992;
8750-7587/92 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Reid, W. D.
Right arrow Articles by Tesler-Mabe, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Reid, W. D.
Right arrow Articles by Tesler-Mabe, C.

Journal of Applied Physiology, Vol 73, Issue 4 1671-1675, Copyright © 1992 by American Physiological Society

ARTICLES

Ventilatory failure induced by tracheal banding in the hamster

W. D. Reid, J. Noonan, F. Chung and C. Tesler-Mabe
University of British Columbia Pulmonary Research Laboratory, St. Paul's Hospital, Vancouver, Canada.

Previous animal models of hypercapnic ventilatory failure are limited in that the resistive load has only been applied acutely and often in anesthetized animals. We therefore developed a chronic animal model of hypercapnic ventilatory failure by increasing airway resistance via tracheal banding over several days. To test the efficacy of this model, we compared arterial blood gases, pulmonary function, and internal area of the trachea 6 days after the banding or sham procedure in 20 hamsters. Six days later, banded animals had an increased airway resistance as indicated by a 66% reduction in internal cross-sectional area of the trachea and a 6.5-fold increase in pulmonary resistance compared with control hamsters. The increased airway resistance resulted in a severe respiratory acidosis and hypoxemia in the awake banded hamsters. Banded hamsters were also hyperinflated. This animal model will be useful for investigating the various mechanisms that contribute to hypercapnic ventilatory failure and interventions that may promote recovery.


This article has been cited by other articles:


Home page
 J. Physiol.Home page
J. A. Simpson, J. Van Eyk, and S. Iscoe
Respiratory muscle injury, fatigue and serum skeletal troponin I in rat
J. Physiol., February 1, 2004; 554(3): 891 - 903.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
W. D. REID and A. N. BELCASTRO
Time Course of Diaphragm Injury and Calpain Activity During Resistive Loading
Am. J. Respir. Crit. Care Med., November 1, 2000; 162(5): 1801 - 1806.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online