| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Journal of Applied Physiology, Vol 73, Issue 3 1150-1158, Copyright © 1992 by American Physiological Society
ARTICLES |
A. R. Elliott, Z. Fu, K. Tsukimoto, R. Prediletto, O. Mathieu-Costello and J. B. West
Department of Medicine, University of California, San Diego, La Jolla 92093-0623.
We previously showed that when the pulmonary capillaries in anesthetized rabbits are exposed to a transmural pressure (Ptm) of approximately 40 mmHg, stress failure of the walls occurs with disruption of the capillary endothelium, alveolar epithelium, or sometimes all layers. The present study was designed to determine whether some of the ultrastructural changes are rapidly reversible when the capillary pressure is reduced. To test this, the Ptm was raised to 52.5 cmH2O for 1 min of blood perfusion and then reduced to 12.5 cmH2O for 3 min of saline-dextran perfusion, followed by intravascular fixation at the same pressure. In another group of animals, the pressure was elevated for 1 min of blood and 3 min of saline-dextran before being reduced. The results were compared with previous studies in which the capillary pressures were maintained elevated at 52.5 cmH2O during the entire procedure. Control studies were also done at sustained low pressures. The results showed that the number of endothelial and epithelial breaks per millimeter and the total fraction area of the breaks were reduced when the pressure was lowered. For example, the number of endothelial breaks per millimeter decreased from 7.1 +/- 2.1 to 2.4 +/- 0.7, and the number of epithelial breaks per millimeter fell from 11.4 +/- 3.7 to 3.4 +/- 0.7. There was evidence that the breaks that closed were those that were initially small and were associated with an intact basement membrane. The results suggest that cells can move along their underlying matrix by rapid disengagement and reattachment of cell adhesion molecules, causing breaks to open or close within minutes.(ABSTRACT TRUNCATED AT 250 WORDS)
This article has been cited by other articles:
|
|
 |
|
  R. B. Schoene Illnesses at High Altitude Chest, August 1, 2008; 134(2): 402 - 416. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. N. Maina and J. B. West Thin and Strong! The Bioengineering Dilemma in the Structural and Functional Design of the Blood-Gas Barrier Physiol Rev, July 1, 2005; 85(3): 811 - 844. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. E. Vlahakis and R. D. Hubmayr Cellular Stress Failure in Ventilator-injured Lungs Am. J. Respir. Crit. Care Med., June 15, 2005; 171(12): 1328 - 1342. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. H. Doerr, O. Gajic, J. C. Berrios, S. Caples, M. Abdel, J. F. Lymp, and R. D. Hubmayr Hypercapnic Acidosis Impairs Plasma Membrane Wound Resealing in Ventilator-injured Lungs Am. J. Respir. Crit. Care Med., June 15, 2005; 171(12): 1371 - 1377. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. B. West The Physiologic Basis of High-Altitude Diseases Ann Intern Med, November 16, 2004; 141(10): 789 - 800. [Full Text] [PDF]
|
|
|
|
|
|
Y. Adir, A. Shupak, A. Gil, N. Peled, Y. Keynan, L. Domachevsky, and D. Weiler-Ravell Swimming-Induced Pulmonary Edema: Clinical Presentation and Serial Lung Function Chest, August 1, 2004; 126(2): 394 - 399. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. Parker and M. I. Townsley Evaluation of lung injury in rats and mice Am J Physiol Lung Cell Mol Physiol, February 1, 2004; 286(2): L231 - L246. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Hanel, I. Law, and J. Mortensen Maximal rowing has an acute effect on the blood-gas barrier in elite athletes J Appl Physiol, September 1, 2003; 95(3): 1076 - 1082. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. B. West Thoughts on the pulmonary blood-gas barrier Am J Physiol Lung Cell Mol Physiol, September 1, 2003; 285(3): L501 - L513. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Gajic, J. Lee, C. H. Doerr, J. C. Berrios, J. L. Myers, and R. D. Hubmayr Ventilator-induced Cell Wounding and Repair in the Intact Lung Am. J. Respir. Crit. Care Med., April 15, 2003; 167(8): 1057 - 1063. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Schaufelberger Pulmonary diffusion capacity as prognostic marker in chronic heart failure Eur. Heart J., March 2, 2002; 23(6): 429 - 431. [Full Text] [PDF]
|
|
|
|
 |
|
 P. H. Hackett and R. C. Roach High-Altitude Illness N. Engl. J. Med., July 12, 2001; 345(2): 107 - 114. [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. Welsh, B. P. H. Guery, B. P. Deboisblanc, E. P. Dobard, C. Creusy, D. Mercante, S. Nelson, W. R. Summer, and C. M. Mason Keratinocyte growth factor attenuates hydrostatic pulmonary edema in an isolated, perfused rat lung model Am J Physiol Heart Circ Physiol, March 1, 2001; 280(3): H1311 - H1317. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. B. Maron, Z. Fu, O. Mathieu-Costello, and J. B. West Effect of high transcapillary pressures on capillary ultrastructure and permeability coefficients in dog lung J Appl Physiol, February 1, 2001; 90(2): 638 - 648. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. B. West Cellular Responses to Mechanical Stress: Invited Review: Pulmonary capillary stress failure J Appl Physiol, December 1, 2000; 89(6): 2483 - 2489. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Puri, D. P. Dutka, B. L. Baker, J. M. B. Hughes, and J. G. F. Cleland Acute Saline Infusion Reduces Alveolar-Capillary Membrane Conductance and Increases Airflow Obstruction in Patients With Left Ventricular Dysfunction Circulation, March 9, 1999; 99(9): 1190 - 1196. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. F. Pierre, K. N. DeCampos, M. Liu, V. Edwards, E. Cutz, A. S. Slutsky, and S. H. Keshavjee RAPID REPERFUSION CAUSES STRESS FAILURE IN ISCHEMIC RAT LUNGS J. Thorac. Cardiovasc. Surg., December 1, 1998; 116(6): 932 - 942. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Tschumperlin and S. S. Margulies Equibiaxial deformation-induced injury of alveolar epithelial cells in vitro Am J Physiol Lung Cell Mol Physiol, December 1, 1998; 275(6): L1173 - L1183. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Parker, C. L. Ivey, and A. Tucker Phosphotyrosine phosphatase and tyrosine kinase inhibition modulate airway pressure-induced lung injury J Appl Physiol, November 1, 1998; 85(5): 1753 - 1761. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Parker, C. L. Ivey, and J. A. Tucker Gadolinium prevents high airway pressure-induced permeability increases in isolated rat lungs J Appl Physiol, April 1, 1998; 84(4): 1113 - 1118. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. E. Fisher Jr., A. Cziraki, C. M. Steinhart, and J. D. Catravas Unaltered pulmonary capillary surface area in the presence of changing arterial resistance Am J Physiol Lung Cell Mol Physiol, February 1, 1998; 274(2): L264 - L269. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Parker and C. L. Ivey Isoproterenol attenuates high vascular pressure-induced permeability increases in isolated rat lungs J Appl Physiol, December 1, 1997; 83(6): 1962 - 1967. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. K. Birks, O. Mathieu-Costello, Z. Fu, W. S. Tyler, and J. B. West Very high pressures are required to cause stress failure of pulmonary capillaries in Thoroughbred racehorses J Appl Physiol, May 1, 1997; 82(5): 1584 - 1592. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Ermert, H.-R. Duncker, H. Bruckner, F. Grimminger, T. Hansen, R. Rossig, K. Aktories, and W. Seeger Ultrastructural changes of lung capillary endothelium in response to botulinum C2 toxin J Appl Physiol, February 1, 1997; 82(2): 382 - 388. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. DREYFUSS and G. SAUMON Ventilator-induced Lung Injury . Lessons from Experimental Studies Am. J. Respir. Crit. Care Med., January 1, 1997; 157(1): 294 - 323. [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
