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J Appl Physiol 73: 94S-100S, 1992;
8750-7587/92 $5.00
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Journal of Applied Physiology, Vol 73, Issue 2 94S-100S, Copyright © 1992 by American Physiological Society

ARTICLES

Cardiac morphology after conditions of microgravity during COSMOS 2044

M. A. Goldstein, R. J. Edwards and J. P. Schroeter
Department of Medicine, Baylor College of Medicine, Houston, Texas 77030.

Light- and electron-microscopic studies were performed on cardiac muscle from rats flown on COS-MOS 2044 and from four control groups. Average cross-sectional area of myofibers was measured by video analysis of the light-microscopic images of papillary and ventricular muscle samples from all animals. This cross-sectional area was significantly decreased in flight rats (P = 0.03) compared with synchronous controls. Additional findings at the electron-microscopic level consistent with this atrophy were obtained by stereological analysis and optical diffraction analysis of papillary muscle samples. Slightly higher mitochondrial volume density values and mitochondria-to-myofibril ratios as well as normal A-band spacings (d1,0) and Z-band spacings of myofibrils were observed in the tail-suspension and flight groups. General morphological features similar to those in ventricular samples from the previous COSMOS 1887 flight were observed.


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