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J Appl Physiol 73: 132S-135S, 1992;
8750-7587/92 $5.00
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Journal of Applied Physiology, Vol 73, Issue 2 132S-135S, Copyright © 1992 by American Physiological Society

ARTICLES

Analyses of plasma for metabolic and hormonal changes in rats flown aboard COSMOS 2044

A. H. Merrill Jr, E. Wang, R. E. Mullins, R. E. Grindeland and I. A. Popova
Department of Biochemistry, Rollins Research Center, Emory University School of Medicine, Atlanta, Georgia 30322.

Plasma samples from rats flown aboard COS-MOS 2044 were analyzed for the levels of key metabolites, electrolytes, enzymes, and hormones. The major differences between the flight group and the synchronous control were elevations in glucose, cholesterol, phosphate, creatinine, blood urea nitrogen, lactate dehydrogenase, and aspartate amino-transferase and decreased levels of thyroxine. Most of these differences were not mimicked by tail suspension of ground-based rats; however, both flight and suspended rats exhibited inhibited testosterone secretion. Corticosterone, immunoreactive growth hormone, and prolactin showed inconsistent differences from the various control groups, suggesting that the levels of these hormones were not due to actual or simulated microgravity.


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