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J Appl Physiol 73: 557-562, 1992;
8750-7587/92 $5.00
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Journal of Applied Physiology, Vol 73, Issue 2 557-562, Copyright © 1992 by American Physiological Society

ARTICLES

Differential uptake of endothelin-1 by the coronary and pulmonary circulations

S. Rimar and C. N. Gillis
Department of Anesthesiology, Yale University School of Medicine, New Haven, Connecticut 06510.

Substantial removal of the vasoconstrictor peptide endothelin-1 (ET-1) by the pulmonary circulation has been reported to occur in perfused guinea pig and rat lungs. We examined the uptake of ET-1 by coronary and pulmonary circulations of the rabbit by measuring single-pass extraction of ET-1 in the isolated heart and lung. In separate experiments, each organ was perfused at 30 ml/min with Krebs-albumin (3%) solution. A bolus of 125I-ET-1 and [14C]dextran in 0.3 ml Krebs-albumin solution was injected, and extraction of endothelin (EET), relative to that of an intravascular reference indicator, [14C]dextran, was determined by multiple indicator-dilution technique. EET was 5 +/- 2% (SE) in the heart and 49 +/- 4% in the lung. Increasing flow rate in the lung preparation to approximate the mean transit time in the heart preparation did not significantly alter EET. Despite insignificant uptake of ET-1, the coronary circulation extracted an angiotensin-converting enzyme inhibitor (351A) and metabolized a synthetic angiotensin-converting enzyme substrate (benzoyl-phenyl-alanyl-proline), both properties of the normal pulmonary circulation. We therefore conclude that there is no significant ET-1 uptake in the coronary vascular bed.


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J. Dupuis, D. J. Stewart, P. Cernacek, and G. Gosselin
Human Pulmonary Circulation Is an Important Site for Both Clearance and Production of Endothelin-1
Circulation, October 1, 1996; 94(7): 1578 - 1584.
[Abstract] [Full Text]


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