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J Appl Physiol 73: 434-439, 1992;
8750-7587/92 $5.00
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Journal of Applied Physiology, Vol 73, Issue 2 434-439, Copyright © 1992 by American Physiological Society

ARTICLES

Effect of volume history on changes in DLcoSB-3EQ with lung volume in normal subjects

D. J. Cotton, F. Taher, J. T. Mink and B. L. Graham
Department of Medicine, University of Saskatchewan, Saskatoon, Canada.

The purpose of this study was to determine the relationship between the three-equation diffusing capacity for carbon monoxide (DLcoSB-3EQ) and lung volume and to determine how this relationship was altered when maneuvers were immediately preceded by a deep breath. DLcoSB-3EQ maneuvers were performed in nine healthy subjects either immediately after a deep breath or after tidal breathing for 10 min. The maneuvers consisted of slow inhalation of test gas from functional residual capacity to 25, 50, 75, or 100% of the inspiratory capacity and, without breath holding, slow exhalation to residual volume. After either a deep breath or tidal breathing, we found that DLcoSB-3EQ decreased nonlinearly with decreasing lung volume. At all lung volumes, DLcoSB-3EQ was significantly greater when measured after a deep breath than after tidal breathing. This effect increased as lung volume decreased, so that the greatest difference between DLcoSB-3EQ after a deep breath and that after tidal breathing occurred at the lowest lung volume. We conclude that a deep breath or spontaneous sigh has a role in reestablishing the pathway for gas exchange during tidal breathing.


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