Journal of Applied Physiology Millar Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 73: 393-404, 1992;
8750-7587/92 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bayliss, D. A.
Right arrow Articles by Millhorn, D. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bayliss, D. A.
Right arrow Articles by Millhorn, D. E.

Journal of Applied Physiology, Vol 73, Issue 2 393-404, Copyright © 1992 by American Physiological Society

ARTICLES

Central neural mechanisms of progesterone action: application to the respiratory system

D. A. Bayliss and D. E. Millhorn
Department of Physiology, University of North Carolina, Chapel Hill 27599-7545.

Around the turn of the century, it was recognized that women hyperventilate during the luteal phase of the menstrual cycle and during pregnancy. Although a causative role for the steroid hormone progesterone in this hyperventilation was suggested as early as the 1940s, there has been no clear indication as to the mechanism by which it produces its respiratory effects. In contrast, much mechanistic information has been obtained over the same period about a different effect of progesterone, i.e., the facilitation of reproductive behaviors. In this case, the bulk of the evidence supports the hypothesis that progesterone acts via a genomic mechanism with characteristics not unlike those predicted by classic models for steroid hormone action. We recently, therefore, undertook a series of experiments to test predictions of those same models with reference to the respiratory effects of progesterone. Here we highlight the results of those studies; as background to and precedent for our experiments, we briefly review previous work in which effects of progesterone on respiration and reproductive behaviors have been studied. Our results indicate that the respiratory response to progesterone is mediated at hypothalamic sites through an estrogen- (E2) dependent progesterone receptor- (PR) mediated mechanism requiring RNA and protein synthesis, i.e., gene expression. The E2 dependence of the respiratory response to progesterone is likely a consequence of the demonstrated induction of PR mRNA and PR in hypothalamic neurons by E2. In short, we found that neural mechanisms underlying the stimulation of respiration by progesterone were similar to those mediating its reproductive effects.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. Soliz, J. J. Thomsen, C. Soulage, C. Lundby, and M. Gassmann
Sex-dependent regulation of hypoxic ventilation in mice and humans is mediated by erythropoietin
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2009; 296(6): R1837 - R1846.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. E. Preston, D. Jensen, I. Janssen, and J. T. Fisher
Effect of menopause on the chemical control of breathing and its relationship with acid-base status
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2009; 296(3): R722 - R727.
[Abstract] [Full Text] [PDF]

Home page
 ERRHome page
B. Buyse and the participants of working group 2
Treatment effects of sleep apnoea: where are we now?
Eur. Respir. Rev., December 1, 2007; 16(106): 146 - 168.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
B. Mokhlesi and A. Tulaimat
Recent Advances in Obesity Hypoventilation Syndrome
Chest, October 1, 2007; 132(4): 1322 - 1336.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
J. A. Guenette, J. D. Witt, D. C. McKenzie, J. D. Road, and A. W. Sheel
Respiratory mechanics during exercise in endurance-trained men and women
J. Physiol., June 15, 2007; 581(3): 1309 - 1322.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
D. Jensen, L. A. Wolfe, L. Slatkovska, K. A. Webb, G. A. L. Davies, and D. E. O'Donnell
Effects of human pregnancy on the ventilatory chemoreflex response to carbon dioxide
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2005; 288(5): R1369 - R1375.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
C. Dehnert, E. Grunig, D. Mereles, N. von Lennep, and P. Bartsch
Identification of individuals susceptible to high-altitude pulmonary oedema at low altitude
Eur. Respir. J., March 1, 2005; 25(3): 545 - 551.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
A. G Zabka, G. S Mitchell, and M Behan
Ageing and gonadectomy have similar effects on hypoglossal long-term facilitation in male Fischer rats
J. Physiol., March 1, 2005; 563(2): 557 - 568.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. Morelli, M. S. Badr, and J. H. Mateika
Ventilatory responses to carbon dioxide at low and high levels of oxygen are elevated after episodic hypoxia in men compared with women
J Appl Physiol, November 1, 2004; 97(5): 1673 - 1680.
[Abstract] [Full Text] [PDF]

Home page
 The Annals of PharmacotherapyHome page
M. J Bales and E. M Timpe
Respiratory Stimulant Use in Chronic Obstructive Pulmonary Disease
Ann. Pharmacother., October 1, 2004; 38(10): 1722 - 1725.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
V. D. Doan, S. Gagnon, and V. Joseph
Prenatal blockade of estradiol synthesis impairs respiratory and metabolic responses to hypoxia in newborn and adult rats
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2004; 287(3): R612 - R618.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
M. Wagenaar, P. Vos, Y. Heijdra, L. Teppema, and H. Folgering
Comparison of Acetazolamide and Medroxyprogesterone as Respiratory Stimulants in Hypercapnic Patients With COPD
Chest, May 1, 2003; 123(5): 1450 - 1459.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
M. Wagenaar, P. Je Vos, Y.F. Heijdra, L.J. Teppema, and H.T.M. Folgering
Combined treatment with acetazolamide and medroxyprogesterone in chronic obstructive pulmonary disease patients
Eur. Respir. J., November 1, 2002; 20(5): 1130 - 1137.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
O. Pascual, M.-P. Morin-Surun, B. Barna, M. Denavit-Saubie, J.-M. Pequignot, and J. Champagnat
Progesterone reverses the neuronal responses to hypoxia in rat nucleus tractus solitarius in vitro
J. Physiol., October 15, 2002; 544(2): 511 - 520.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
J. Weisberg, J. Wanger, J. Olson, B. Streit, C. Fogarty, T. Martin, and R. Casaburi
Megestrol Acetate Stimulates Weight Gain and Ventilation in Underweight COPD Patients*
Chest, April 1, 2002; 121(4): 1070 - 1078.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
V. Joseph, J. Soliz, R. Soria, J. Pequignot, R. Favier, H. Spielvogel, and J. M. Pequignot
Dopaminergic metabolism in carotid bodies and high-altitude acclimatization in female rats
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2002; 282(3): R765 - R773.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
T. D. Brutsaert, H. Spielvogel, E. Caceres, M. Araoz, R. T. Chatterton, and V. J. Vitzthum
Effect of menstrual cycle phase on exercise performance of high-altitude native women at 3600 m
J. Exp. Biol., January 15, 2002; 205(2): 233 - 239.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A. G. Zabka, M. Behan, and G. S. Mitchell
Genome and Hormones: Gender Differences in Physiology: Selected Contribution: Time-dependent hypoxic respiratory responses in female rats are influenced by age and by the estrus cycle
J Appl Physiol, December 1, 2001; 91(6): 2831 - 2838.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
R. J. Preston, A. P. Heenan, and L. A. Wolfe
Physicochemical analysis of phasic menstrual cycle effects on acid-base balance
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2001; 280(2): R481 - R487.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
F. Leon-Velarde, M. Rivera-Chira, R. Tapia, L. Huicho, and C. Monge-C
Relationship of ovarian hormones to hypoxemia in women residents of 4,300 m
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2001; 280(2): R488 - R493.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
N. EDWARDS, D. M. BLYTON, T. KIRJAVAINEN, G. J. KESBY, and C. E. SULLIVAN
Nasal Continuous Positive Airway Pressure Reduces Sleep-induced Blood Pressure Increments In Preeclampsia
Am. J. Respir. Crit. Care Med., July 1, 2000; 162(1): 252 - 257.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
V. Joseph, J. Soliz, J. Pequignot, B. Sempore, J. M. Cottet-Emard, Y. Dalmaz, R. Favier, H. Spielvogel, and J. M. Pequignot
Gender differentiation of the chemoreflex during growth at high altitude: functional and neurochemical studies
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2000; 278(4): R806 - R816.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A. P. Heenan and L. A. Wolfe
Plasma acid-base regulation above and below ventilatory threshold in late gestation
J Appl Physiol, January 1, 2000; 88(1): 149 - 157.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
B. J. Orr-Walker, A. M. Horne, M. C. Evans, A. B. Grey, M. A. F. Murray, A. R. McNeil, and I. R. Reid
Hormone Replacement Therapy Causes a Respiratory Alkalosis in Normal Postmenopausal Women
J. Clin. Endocrinol. Metab., June 1, 1999; 84(6): 1997 - 2001.
[Abstract] [Full Text]

Home page
 J. Appl. Physiol.Home page
B. A. Beidleman, P. B. Rock, S. R. Muza, C. S. Fulco, V. A. Forte Jr., and A. Cymerman
Exercise VE and physical performance at altitude are not affected by menstrual cycle phase
J Appl Physiol, May 1, 1999; 86(5): 1519 - 1526.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
K. Tatsumi, C. K. Pickett, C. R. Jacoby, J. V. Weil, and L. G. Moore
Role of endogenous female hormones in hypoxic chemosensitivity
J Appl Physiol, November 1, 1997; 83(5): 1706 - 1710.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. G. Kemp, F. A. Greer, and L. A. Wolfe
Acid-base regulation after maximal exercise testing in late gestation
J Appl Physiol, August 1, 1997; 83(2): 644 - 651.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online