Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 72: 2210-2218, 1992;
8750-7587/92 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by McDonald, K. S.
Right arrow Articles by Fitts, R. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by McDonald, K. S.
Right arrow Articles by Fitts, R. H.

Journal of Applied Physiology, Vol 72, Issue 6 2210-2218, Copyright © 1992 by American Physiological Society

ARTICLES

Effect of hindlimb unweighting on tissue blood flow in the rat

K. S. McDonald, M. D. Delp and R. H. Fitts
Biology Department/Biological and Biomedical Research Institute, Marquette University, Milwaukee, Wisconsin 53233.

The purpose of this study was to characterize the distribution of blood flow in the rat during hindlimb unweighting (HU) and post-HU standing and exercise and examine whether the previously reported (Witzmann et al., J. Appl. Physiol. 54: 1242-1248, 1983) elevation in anaerobic metabolism observed with contractile activity in the atrophied soleus muscle was caused by a reduced hindlimb blood flow. After either 15 days of HU or cage control, blood flow was measured with radioactive microspheres during unweighting, normal standing, and running on a treadmill (15 m/min). In another group of control and experimental animals, blood flow was measured during preexercise (PE) treadmill standing and treadmill running (15 m/min). Soleus muscle blood flow was not different between groups during unweighting, PE standing, and running at 15 m/min. Chronic unweighting resulted in the tendency for greater blood flow to muscles composed of predominantly fast-twitch glycolytic fibers. With exercise, blood flow to visceral organs was reduced compared with PE values in the control rats, whereas flow to visceral organs in 15-day HU animals was unaltered by exercise. These higher flows to the viscera and to muscles composed of predominantly fast-twitch glycolytic fibers suggest an apparent reduction in the ability of the sympathetic nervous system to distribute cardiac output after chronic HU. In conclusion, because 15 days of HU did not affect blood flow to the soleus during exercise, the increased dependence of the atrophied soleus on anerobic energy production during contractile activity cannot be explained by a reduced muscle blood flow.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
P. Arbeille, P. Kerbeci, L. Mattar, J. K. Shoemaker, and R. Hughson
Insufficient flow reduction during LBNP in both splanchnic and lower limb areas is associated with orthostatic intolerance after bedrest
Am J Physiol Heart Circ Physiol, November 1, 2008; 295(5): H1846 - H1854.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
L.-F. Zhang, J.-H. Cheng, X. Liu, S. Wang, Y. Liu, H.-B. Lu, and J. Ma
Cardiovascular changes of conscious rats after simulated microgravity with and without daily -Gx gravitation
J Appl Physiol, October 1, 2008; 105(4): 1134 - 1145.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
B. J. Behnke, D. C. Zawieja, A. A. Gashev, C. A. Ray, and M. D. Delp
Diminished mesenteric vaso- and venoconstriction and elevated plasma ANP and BNP with simulated microgravity
J Appl Physiol, May 1, 2008; 104(5): 1273 - 1280.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
W. G. Schrage
Not a search in vein: novel stimulus for vascular dysfunction after simulated microgravity
J Appl Physiol, May 1, 2008; 104(5): 1257 - 1258.
[Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. D. Delp
Unraveling the complex web of impaired wound healing with mechanical unloading and physical deconditioning
J Appl Physiol, May 1, 2008; 104(5): 1262 - 1263.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
P. N. Colleran, B. J. Behnke, M. K. Wilkerson, A. J. Donato, and M. D. Delp
Simulated microgravity alters rat mesenteric artery vasoconstrictor dynamics through an intracellular Ca2+ release mechanism
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2008; 294(5): R1577 - R1585.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
C. A. Ray
New insights into orthostatic hypotension
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2008; 294(5): R1575 - R1576.
[Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
P. Arbeille, P. Kerbeci, L. Mattar, J. K. Shoemaker, and R. L. Hughson
WISE-2005: tibial and gastrocnemius vein and calf tissue response to LBNP after a 60-day bed rest with and without countermeasures
J Appl Physiol, April 1, 2008; 104(4): 938 - 943.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
D. A. Martinez, A. C. Vailas, R. Vanderby Jr., and R. E. Grindeland
Temporal extracellular matrix adaptations in ligament during wound healing and hindlimb unloading
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2007; 293(4): R1552 - R1560.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. Hwang, S. A. Shelkovnikov, and R. E. Purdy
Simulated microgravity effects on the rat carotid and femoral arteries: role of contractile protein expression and mechanical properties of the vessel wall
J Appl Physiol, April 1, 2007; 102(4): 1595 - 1603.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. D. Delp
Arterial adaptations in microgravity contribute to orthostatic tolerance
J Appl Physiol, March 1, 2007; 102(3): 836 - 836.
[Full Text] [PDF]

Home page
 J. Physiol.Home page
B. J. Behnke, R. D. Prisby, L. A. Lesniewski, A. J. Donato, H. M. Olin, and M. D. Delp
Influence of ageing and physical activity on vascular morphology in rat skeletal muscle
J. Physiol., September 1, 2006; 575(2): 617 - 626.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. D. Prisby, M. K. Wilkerson, E. M. Sokoya, R. M. Bryan Jr., E. Wilson, and M. D. Delp
Endothelium-dependent vasodilation of cerebral arteries is altered with simulated microgravity through nitric oxide synthase and EDHF mechanisms
J Appl Physiol, July 1, 2006; 101(1): 348 - 353.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
P. J. Mueller, M. J. Sullivan, R. R. Grindstaff, J. T. Cunningham, and E. M. Hasser
Regulation of plasma vasopressin and renin activity in conscious hindlimb-unloaded rats
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2006; 291(1): R46 - R52.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. A. Gashev, M. D. Delp, and D. C. Zawieja
Inhibition of active lymph pump by simulated microgravity in rats
Am J Physiol Heart Circ Physiol, June 1, 2006; 290(6): H2295 - H2308.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. W. Zderic and M. T. Hamilton
Physical inactivity amplifies the sensitivity of skeletal muscle to the lipid-induced downregulation of lipoprotein lipase activity
J Appl Physiol, January 1, 2006; 100(1): 249 - 257.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. S. Jung, R. Harrison, K. H. Lee, J. Genut, D. Nyhan, E. M. Brooks-Asplund, A. A. Shoukas, J. M. Hare, and D. E. Berkowitz
Simulated microgravity produces attenuated baroreflex-mediated pressor, chronotropic, and inotropic responses in mice
Am J Physiol Heart Circ Physiol, August 1, 2005; 289(2): H600 - H607.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
P. J. Mueller, C. M. Foley, and E. M. Hasser
Hindlimb unloading alters nitric oxide and autonomic control of resting arterial pressure in conscious rats
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2005; 289(1): R140 - R147.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
H. Fujino, H. Kohzuki, I. Takeda, T. Kiyooka, T. Miyasaka, S. Mohri, J. Shimizu, and F. Kajiya
Regression of capillary network in atrophied soleus muscle induced by hindlimb unweighting
J Appl Physiol, April 1, 2005; 98(4): 1407 - 1413.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
M. K. Wilkerson, L. A. Lesniewski, E. M. Golding, R. M. Bryan Jr., A. Amin, E. Wilson, and M. D. Delp
Simulated microgravity enhances cerebral artery vasoconstriction and vascular resistance through endothelial nitric oxide mechanism
Am J Physiol Heart Circ Physiol, April 1, 2005; 288(4): H1652 - H1661.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
C. Dapp, S. Schmutz, H. Hoppeler, and M. Fluck
Transcriptional reprogramming and ultrastructure during atrophy and recovery of mouse soleus muscle
Physiol Genomics, December 15, 2004; 20(1): 97 - 107.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. Powers and D. Bernstein
The mouse as a model of cardiovascular adaptations to microgravity
J Appl Physiol, November 1, 2004; 97(5): 1686 - 1692.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
Z.-J. Fu, M.-J. Xie, L.-F. Zhang, H.-W. Cheng, and J. Ma
Differential activation of potassium channels in cerebral and hindquarter arteries of rats during simulated microgravity
Am J Physiol Heart Circ Physiol, October 1, 2004; 287(4): H1505 - H1515.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. A. Moffitt and A. K. Johnson
Short-term fluoxetine treatment enhances baroreflex control of sympathetic nervous system activity after hindlimb unloading
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2004; 286(3): R584 - R590.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
L. Bey and M. T Hamilton
Suppression of skeletal muscle lipoprotein lipase activity during physical inactivity: a molecular reason to maintain daily low-intensity activity
J. Physiol., September 1, 2003; 551(2): 673 - 682.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A. Papadopoulos and M. D. Delp
Effects of hindlimb unweighting on the mechanical and structure properties of the rat abdominal aorta
J Appl Physiol, February 1, 2003; 94(2): 439 - 445.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. Ma, C. I. Kahwaji, Z. Ni, N. D. Vaziri, and R. E. Purdy
Effects of simulated microgravity on arterial nitric oxide synthase and nitrate and nitrite content
J Appl Physiol, January 1, 2003; 94(1): 83 - 92.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. M. Muller-Delp, S. A. Spier, M. W. Ramsey, and M. D. Delp
Aging impairs endothelium-dependent vasodilation in rat skeletal muscle arterioles
Am J Physiol Heart Circ Physiol, October 1, 2002; 283(4): H1662 - H1672.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. A. Moffitt, C. M. Heesch, and E. M. Hasser
Increased GABAA inhibition of the RVLM after hindlimb unloading in rats
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2002; 283(3): R604 - R614.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
W. G. Schrage, C. R. Woodman, and M. H. Laughlin
Mechanisms of flow and ACh-induced dilation in rat soleus arterioles are altered by hindlimb unweighting
J Appl Physiol, March 1, 2002; 92(3): 901 - 911.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. L. Heaps and D. K. Bowles
Nonuniform changes in arteriolar myogenic tone within skeletal muscle following hindlimb unweighting
J Appl Physiol, March 1, 2002; 92(3): 1145 - 1151.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. C. Hatton, Q. Yue, J. Chapman, H. Xue, J. Dierickx, C. Roullet, S. Coste, J. B. Roullet, and D. A. McCarron
Blood pressure and mesenteric resistance arterial function after spaceflight
J Appl Physiol, January 1, 2002; 92(1): 13 - 17.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. Nyhan, S. Kim, S. Dunbar, D. Li, A. Shoukas, and D. E. Berkowitz
Impaired pulmonary artery contractile responses in a rat model of microgravity: role of nitric oxide
J Appl Physiol, January 1, 2002; 92(1): 33 - 40.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
M. K. Wilkerson, P. N. Colleran, and M. D. Delp
Acute and chronic head-down tail suspension diminishes cerebral perfusion in rats
Am J Physiol Heart Circ Physiol, January 1, 2002; 282(1): H328 - H334.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
L.-F. Zhang
Vascular adaptation to microgravity: what have we learned?
J Appl Physiol, December 1, 2001; 91(6): 2415 - 2430.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. R. Woodman, W. G. Schrage, J. W. E. Rush, C. A. Ray, E. M. Price, E. M. Hasser, and M. H. Laughlin
Hindlimb unweighting decreases endothelium-dependent dilation and eNOS expression in soleus not gastrocnemius
J Appl Physiol, September 1, 2001; 91(3): 1091 - 1098.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. A. Ray, M. Vasques, T. A. Miller, M. K. Wilkerson, and M. D. Delp
Effect of short-term microgravity and long-term hindlimb unloading on rat cardiac mass and function
J Appl Physiol, September 1, 2001; 91(3): 1207 - 1213.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. S. Sangha, S. Han, and R. E. Purdy
Simulated microgravity upregulates an endothelial vasoconstrictor prostaglandin
J Appl Physiol, August 1, 2001; 91(2): 789 - 796.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
W. G. Schrage, C. R. Woodman, and M. H. Laughlin
Hindlimb unweighting alters endothelium-dependent vasodilation and ecNOS expression in soleus arterioles
J Appl Physiol, October 1, 2000; 89(4): 1483 - 1490.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
P. N. Colleran, M. K. Wilkerson, S. A. Bloomfield, L. J. Suva, R. T. Turner, and M. D. Delp
Alterations in skeletal perfusion with simulated microgravity: a possible mechanism for bone remodeling
J Appl Physiol, September 1, 2000; 89(3): 1046 - 1054.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. R. McCurdy, P. N. Colleran, J. Muller-Delp, and M. D. Delp
Physiology of a Microgravity Environment: Selected Contribution: Effects of fiber composition and hindlimb unloading on the vasodilator properties of skeletal muscle arterioles
J Appl Physiol, July 1, 2000; 89(1): 398 - 405.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
M. D. Delp, P. N. Colleran, M. K. Wilkerson, M. R. McCurdy, and J. Muller-Delp
Structural and functional remodeling of skeletal muscle microvasculature is induced by simulated microgravity
Am J Physiol Heart Circ Physiol, June 1, 2000; 278(6): H1866 - H1873.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. C. Looft-Wilson and C. V. Gisolfi
Rat small mesenteric artery function after hindlimb suspension
J Appl Physiol, April 1, 2000; 88(4): 1199 - 1206.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
V. P. Grichko, A. Heywood-Cooksey, K. R. Kidd, and R. H. Fitts
Substrate profile in rat soleus muscle fibers after hindlimb unloading and fatigue
J Appl Physiol, February 1, 2000; 88(2): 473 - 478.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. A. Riley, J. L. W. Bain, J. L. Thompson, R. H. Fitts, J. J. Widrick, S. W. Trappe, T. A. Trappe, and D. L. Costill
Decreased thin filament density and length in human atrophic soleus muscle fibers after spaceflight
J Appl Physiol, February 1, 2000; 88(2): 567 - 572.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. K. Wilkerson, J. Muller-Delp, P. N. Colleran, and M. D. Delp
Effects of hindlimb unloading on rat cerebral, splenic, and mesenteric resistance artery morphology
J Appl Physiol, December 1, 1999; 87(6): 2115 - 2121.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. L. Jasperse, C. R. Woodman, E. M. Price, E. M. Hasser, and M. H. Laughlin
Hindlimb unweighting decreases ecNOS gene expression and endothelium-dependent dilation in rat soleus feed arteries
J Appl Physiol, October 1, 1999; 87(4): 1476 - 1482.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. D. Delp
Myogenic and vasoconstrictor responsiveness of skeletal muscle arterioles is diminished by hindlimb unloading
J Appl Physiol, April 1, 1999; 86(4): 1178 - 1184.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G. G. Geary, D. N. Krause, R. E. Purdy, and S. P. Duckles
Simulated microgravity increases myogenic tone in rat cerebral arteries
J Appl Physiol, November 1, 1998; 85(5): 1615 - 1621.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. E. Purdy, S. P. Duckles, D. N. Krause, K. M. Rubera, and D. Sara
Effect of simulated microgravity on vascular contractility
J Appl Physiol, October 1, 1998; 85(4): 1307 - 1315.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. K. Shoemaker, C. S. Hogeman, D. H. Silber, K. Gray, M. Herr, and L. I. Sinoway
Head-down-tilt bed rest alters forearm vasodilator and vasoconstrictor responses
J Appl Physiol, May 1, 1998; 84(5): 1756 - 1762.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. A. Moffitt, C. M. Foley, J. C. Schadt, M. H. Laughlin, and E. M. Hasser
Attenuated baroreflex control of sympathetic nerve activity after cardiovascular deconditioning in rats
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 1998; 274(5): R1397 - R1405.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J.-L. Morel, F.-X. Boittin, G. Halet, S. Arnaudeau, C. Mironneau, and J. Mironneau
Effect of a 14-day hindlimb suspension on cytosolic Ca2+ concentration in rat portal vein myocytes
Am J Physiol Heart Circ Physiol, December 1, 1997; 273(6): H2867 - H2875.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol Ind HealthHome page
R. P. Brown, M. D. Delp, S. L. Lindstedt, L. R. Rhomberg, and R. P. Beliles
Physiological Parameter Values for Physiologically Based Pharmacokinetic Models
Toxicology and Industrial Health, July 1, 1997; 13(4): 407 - 484.
[PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online