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J Appl Physiol 72: 2047-2051, 1992;
8750-7587/92 $5.00
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Journal of Applied Physiology, Vol 72, Issue 6 2047-2051, Copyright © 1992 by American Physiological Society

ARTICLES

Significance of plasma skimming and plasma volume expansion

V. Jonsson, J. E. Bock and J. B. Nielsen
Department of Hematology, Rigshospitalet, Medical School, University of Copenhagen, Denmark.

The organs associated with plasma volume expansion, i.e., the red bone marrow, the enlarged spleen, and the uteroplacental complex, are arteriovenous shunts with an interposed sinusoidal stroma able to skim off plasma-rich blood. In the spleen, plasma separation is an integral part of the hemoconcentration. In the red bone marrow, plasma skimming might provide a washout mechanism for the many newly formed erythrocytes and platelets from the sinusoids to the peripheral blood circulation. In the uteroplacental complex, skimming of plasma-rich blood is beneficial in increasing blood flow in the myometrium, kidneys, and skeletal musculature. The hypervolemic status with anemia will simulate a negative iron balance, which speeds up the absorption of iron. Thus a conceptual unit seems to exist in which rheological factors influence such functions as transport of newly formed blood cells into the circulation (in the red bone marrow), hemoconcentration (in the spleen), and iron balance during pregnancy (in the uteroplacental complex).


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