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J Appl Physiol 72: 2018-2023, 1992;
8750-7587/92 $5.00
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Journal of Applied Physiology, Vol 72, Issue 5 2018-2023, Copyright © 1992 by American Physiological Society

ARTICLES

Rapid onset of hypoxic vasoconstriction in isolated lungs

K. S. Jensen, A. J. Micco, J. Czartolomna, L. Latham and N. F. Voelkel
Cardiovascular Pulmonary Research Laboratory, University of Colorado Health Sciences Center, Denver 80262.

A fast-response O2 analyzer that samples air at low flow rates allows the quasi-instantaneous measurement of O2 concentration change in the airways of isolated blood-perfused rat lungs. This instrument and an oximeter were used to measure the stimulus-response delay time of hypoxic pulmonary vasoconstriction when the lungs were challenged with 10, 5, or 3% O2. The estimate for the shortest delay time between accomplished fall in airway O2 concentration and the onset of hypoxia-induced vasoconstriction was approximately 7 s. We found that the slope of pressure rise, but not the stimulus-response delay time, correlated with the magnitude of hypoxic vasoconstriction. Oscillations in pulmonary arterial pressure were observed when the lungs were challenged with 10% O2 but not when the challenge was 12, 5, or 3%, indicating perhaps that these oscillations were a threshold phenomenon. Established hypoxic vasoconstriction was sensitive to brief changes in airway O2 concentration. Vasodilation occurred when the gas mixture was switched from 3 to 21% O2 for two to five breaths, and vasoconstriction occurred when the gas was changed during a single breath from 5 to 3% O2.


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