Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 72: 1895-1901, 1992;
8750-7587/92 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hurtado, F. J.
Right arrow Articles by Gutierrez, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hurtado, F. J.
Right arrow Articles by Gutierrez, G.

Journal of Applied Physiology, Vol 72, Issue 5 1895-1901, Copyright © 1992 by American Physiological Society

ARTICLES

Role of tissue hypoxia as the mechanism of lactic acidosis during E. coli endotoxemia

F. J. Hurtado, A. M. Gutierrez, N. Silva, E. Fernandez, A. E. Khan and G. Gutierrez
Pulmonary and Critical Care Medicine Division, University of Texas, Houston 77030.

We compared the hemodynamic and metabolic alterations produced in rabbits by similar decreases in cardiac output created by inflating a balloon placed in the right ventricle (n = 6) with those produced by an intravenous bolus of Escherichia coli lipopolysaccharide (LPS; SEP group; n = 6). We measured O2 consumption (VO2), O2 transport (TO2), and O2 extraction ratio (ERO2) for the whole animal and also for the left hindlimb. Both groups experienced similar decreases in cardiac output, systemic TO2, and VO2 and similar increases in ERO2. For the hindlimb, TO2 was similar, but VO2 and ERO2 were lower for the SEP group 30 min after LPS administration (P less than 0.05); however, this difference disappeared during the remainder of the experiment. Arterial lactate concentration was greater (P less than 0.05) for the SEP group. There were no differences in skeletal muscle PO2, measured with a multiwire surface electrode, or in cardiac and skeletal muscle concentrations of high-energy phosphates. We hypothesize that a direct effect of LPS on cellular metabolism may have resulted in greater arterial lactate concentration for the SEP group.


This article has been cited by other articles:


Home page
 J Intensive Care MedHome page
P. J. Fall and H. M. Szerlip
Lactic Acidosis: From Sour Milk to Septic Shock
J Intensive Care Med, September 1, 2005; 20(5): 255 - 271.
[Abstract] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
C. CHRUSCH, C. BANDS, D. BOSE, X. LI, H. JACOBS, K. DUKE, E. BAUTISTA, G. ESCHUN, R. BRUCE LIGHT, and S. N. MINK
Impaired Hepatic Extraction and Increased Splanchnic Production Contribute to Lactic Acidosis in Canine Sepsis
Am. J. Respir. Crit. Care Med., February 1, 2000; 161(2): 517 - 526.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
Y. MATUSZCZAK, N. VIIRES, H. ALLAMEDIN, M. AUBIER, J.-M. DESMONTS, and B. DUREUIL
Alteration in Diaphragmatic Function Induced by Acute Necrotizing Pancreatitis in a Rodent Model
Am. J. Respir. Crit. Care Med., November 1, 1999; 160(5): 1623 - 1628.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. LEVRAUT, J.-P. CIEBIERA, S. CHAVE, O. RABARY, P. JAMBOU, M. CARLES, and D. GRIMAUD
Mild Hyperlactatemia in Stable Septic Patients Is Due to Impaired Lactate Clearance Rather Than Overproduction
Am. J. Respir. Crit. Care Med., April 1, 1998; 157(4): 1021 - 1026.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online