Journal of Applied Physiology AJP: Lung Cellular and Molecular Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 72: 1826-1830, 1992;
8750-7587/92 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gladden, L. B.
Right arrow Articles by Webster, M. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gladden, L. B.
Right arrow Articles by Webster, M. J.

Journal of Applied Physiology, Vol 72, Issue 5 1826-1830, Copyright © 1992 by American Physiological Society

ARTICLES

Effect of blood flow on net lactate uptake during steady-level contractions in canine skeletal muscle

L. B. Gladden, R. E. Crawford and M. J. Webster
Department of Health and Human Performance, Auburn University, Alabama 36849-5323.

The purpose of this study was to determine the effect of blood flow on net lactate uptake (L) at constant elevated blood lactate concentration and metabolic rate in the in situ dog gastrocnemius-plantaris (GP) muscle. In all experiments, an infusion of lactate/lactic acid at a pH of 3.8 established a blood lactate concentration of 10-13 mM while maintaining normal blood gas/pH status as the GP was stimulated to contract with twitches at 1 Hz. In series 1 (n = 14), blood flow (ml.kg-1.min-1) was controlled by a pump at either 1) the spontaneous level for 1-Hz contractions (control flow = 332 +/- 23) or 2) a level estimated to be approximately 65% greater (high flow = 543 +/- 42). In series 2 (n = 7), perfusion pressure was varied during 1-Hz contractions. Four different perfusion pressures (80, 120, 155, and 180 Torr) were presented to each GP preparation, resulting in mean flow rates of 308 +/- 34, 419 +/- 30, 492 +/- 37, and 646 +/- 30 ml.kg-1.min-1. Increasing blood flow had no significant effect on net L in series 1. Similarly, there was no significant change in net L across the first three perfusion pressures/flow rates in series 2. However, net L (mmol.kg-1.min-1) was significantly increased in the highest perfusion pressure/flow rate period (from 0.335 +/- 0.029 at 80 Torr to 0.431 +/- 0.034 at 180 Torr). This study suggests that blood flow may have an independent effect on net L at the upper extreme of the normal blood flow range during contractions but very little effect over a fairly wide low-to-middle range of flow rates.


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
J. L. Dobson and L. B. Gladden
Effect of rhythmic tetanic skeletal muscle contractions on peak muscle perfusion
J Appl Physiol, January 1, 2003; 94(1): 11 - 19.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. J. Hamann, K. M. Kelley, and L. B. Gladden
Effect of epinephrine on net lactate uptake by contracting skeletal muscle
J Appl Physiol, December 1, 2001; 91(6): 2635 - 2641.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online