Journal of Applied Physiology AJP: Heart and Circulatory Physiology
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J Appl Physiol 72: 1749-1753, 1992;
8750-7587/92 $5.00
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Journal of Applied Physiology, Vol 72, Issue 5 1749-1753, Copyright © 1992 by American Physiological Society

ARTICLES

Vagal function impairment after exercise training

C. E. Negrao, E. D. Moreira, M. C. Santos, V. M. Farah and E. M. Krieger
Heart Institute, University Hospital, Faculty of Medicine, Sao Paulo, Brazil.

The present investigation was undertaken to evaluate the vagal function of trained (T) and sedentary (S) rats by use of different approaches in the same animal. After 13 wk of exercise training (treadmill for 1 h 5 times/wk at 26.8 m/min and 15% grade), T rats had a resting heart rate (HR) slightly but significantly lower than S rats (299 +/- 3 vs. 308 +/- 3 beats/min). T rats had marked reduction of the intrinsic HR (329 +/- 4 vs. 369 +/- 5 beats/min) after blockade by methylatropine and propranolol. They also exhibited depressed vagal and sympathetic tonus. Baroreflex bradycardia (phenylephrine injections) was reduced, bradycardic responses produced by electrical stimulation of the vagus were depressed, and responses to methacholine injection were decreased in T rats. Therefore several evidences of vagal function impairment were observed in T rats. The resting bradycardia after exercise training is more likely to be dependent on alterations of the pacemaker cells, inasmuch as the intrinsic HR was markedly reduced.


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