Journal of Applied Physiology, Vol 72, Issue 3 1064-1067, Copyright © 1992 by American Physiological Society

ARTICLES

Effect of fatigue on diaphragmatic function at different lung volumes

S. Yan, T. Similowski, A. P. Gauthier, P. T. Macklem and F. Bellemare
Meakins-Christie Laboratories, McGill University Clinic, Royal Victoria Hospital, Montreal, Quebec, Canada.

The transdiaphragmatic pressure twitches (PdiT) in response to single maximal shocks delivered bilaterally to the phrenic nerves were recorded as a function of lung volume when the diaphragm was fresh and when fatigued. All relationships were linear and negatively sloped (all r greater than 0.85). From these relationships PdiT was found to decrease with fatigue more rapidly and to recover more quickly at high than at low lung volumes. Complete recovery of PdiT at all lung volumes was greater than 1 h. Contraction and relaxation rate constants of PdiT did not change significantly with fatigue. We conclude that fatigue affects diaphragm contractility more at high than at low lung volumes and that changes in diaphragm contractility are best reflected in the measurement of PdiT as a function of lung volume.

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